Diversity-oriented synthesis around pyrrole cores .
One of the goals of synthetic Organic Chemistry in recent years is the development of new ways to explore chemical space in order to identify new biologically active entities and use them to uncover new therapeutic targets. The exploration of chemical space requires new synthetic processes, ideally...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | español |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/17165 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/17165 |
| Access Level: | acceso abierto |
| Palabra clave: | 615:54(043.2) Química farmacéutica Pharmaceutical chemistry Química farmaceútica 2390 Química Farmacéutica |
| Sumario: | One of the goals of synthetic Organic Chemistry in recent years is the development of new ways to explore chemical space in order to identify new biologically active entities and use them to uncover new therapeutic targets. The exploration of chemical space requires new synthetic processes, ideally allowing the construction of several bonds in a single operation. In this connection, the MCR chemical space, defined as the ensemble of all possible molecules that can be obtained by multicomponent synthetic processes, is of particular interest. Diversity-Oriented Synthesis (DOS) is a recent approach to the identification of small bioactive molecules that is is designed to explore broader extensions of chemical space, its emphasis being on the generation of diverse scaffolds with varied molecular shapes. It is not directed at a specific biological target, and DOS libraries are used for the fast high-throughput identification of new ligands for varied targets in an effort to locate hit compounds in medicinal chemistry and chemical biology... |
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