Mitochondrial dysfunction in cholestatic liver diseases

et al.

Detalles Bibliográficos
Autores: Sastre, Juan, Tormos, Ana M., Monsalve, María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/152295
Acceso en línea:http://hdl.handle.net/10261/152295
Access Level:acceso abierto
Palabra clave:Mitochondrial function
Review
Oxidative stress
Apoptosis
Bile acids
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spelling Mitochondrial dysfunction in cholestatic liver diseasesSastre, JuanTormos, Ana M.Monsalve, MaríaMitochondrial functionReviewOxidative stressApoptosisBile acidset al.Cholestatic liver diseases are characterized by blockade of bile flow from the liver to the intestine, and accumulation of hydrophobic bile acids in the liver and plasma. As a consequence an inflammatory response evolves associated with increased apoptosis, oxidative stress, and eventually fibrosis. Cholestasis is associated with profound metabolic changes, alterations in the mitochondrial function, decreased fatty acid oxidation, and increased glycolisis. Mitochondria play a central role in the development of this liver disease because they mediate death receptor signaling - triggered by inflammatory cytokines or bile acids - and contribute to oxidative damage, metabolic disorder, and onset of fibrosis. During the pathogenesis of biliary cirrhosis mitochondria's need for renewal is hampered by a blunted mitochondrial biogenesis. Lack of stimulation of mitochondrial renewal helps to explain mitochondrial impairment in long-term cholestasis. The marked depletion of mitochondrial DNA and occurrence of mitochondrial DNA deletions are probably relevant contributors to the progression of this severe disease. All these findings certainly support the consideration of long-term cholestasis as a secondary mitochondrial hepatopathy.Peer ReviewedFrontiers in Bioscience PublicationsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720122017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/152295reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.2741/539Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1522952026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mitochondrial dysfunction in cholestatic liver diseases
title Mitochondrial dysfunction in cholestatic liver diseases
spellingShingle Mitochondrial dysfunction in cholestatic liver diseases
Sastre, Juan
Mitochondrial function
Review
Oxidative stress
Apoptosis
Bile acids
title_short Mitochondrial dysfunction in cholestatic liver diseases
title_full Mitochondrial dysfunction in cholestatic liver diseases
title_fullStr Mitochondrial dysfunction in cholestatic liver diseases
title_full_unstemmed Mitochondrial dysfunction in cholestatic liver diseases
title_sort Mitochondrial dysfunction in cholestatic liver diseases
dc.creator.none.fl_str_mv Sastre, Juan
Tormos, Ana M.
Monsalve, María
author Sastre, Juan
author_facet Sastre, Juan
Tormos, Ana M.
Monsalve, María
author_role author
author2 Tormos, Ana M.
Monsalve, María
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mitochondrial function
Review
Oxidative stress
Apoptosis
Bile acids
topic Mitochondrial function
Review
Oxidative stress
Apoptosis
Bile acids
description et al.
publishDate 2012
dc.date.none.fl_str_mv 2012
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/152295
url http://hdl.handle.net/10261/152295
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.2741/539
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers in Bioscience Publications
publisher.none.fl_str_mv Frontiers in Bioscience Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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