Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation

8 páginas, 4 tablas, 1 figura

Detalhes bibliográficos
Autores: Dasilva, Gabriel, Pazos Palmeiro, Manuel, García-Egido, Eduardo, Gallardo, José Manuel, Rodríguez, Isaac, Cela, Rafael, Medina, Isabel
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/124697
Acesso em linha:http://hdl.handle.net/10261/124697
Access Level:acceso abierto
Palavra-chave:Lipid mediators
Fish oil
EPA
DHA
Oxidative stress
Inflammation
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spelling Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammationDasilva, GabrielPazos Palmeiro, ManuelGarcía-Egido, EduardoGallardo, José ManuelRodríguez, IsaacCela, RafaelMedina, IsabelLipid mediatorsFish oilEPADHAOxidative stressInflammation8 páginas, 4 tablas, 1 figuraDietary intervention with ω-3 marine fatty acids may potentially modulate inflammation and oxidative stress markers related with CVD, metabolic syndrome and cancer. The aim of this study was to evaluate whether different proportions of ω-3 EPA and DHA intake provoke a modulation of the production of lipid mediators and then, an influence on different indexes of inflammation and oxidative stress in a controlled dietary animal experiment using Wistar rats. For such scope, a lipidomic SPE-LC-ESI-MS/MS approach previously developed was applied to determine lipid mediators profile in plasma samples. The effect of ω-3 fatty acids associated to different ratios EPA:DHA was compared with the effect exerted by ω-3 ALA supplementation from linseed oil and ω-6 LA from soybean oil. CRP showed a tendency to greater inflammatory status in all ω-3-fed animals. Interestingly, ratios 1:1 and 2:1 EPA:DHA evidenced a noteworthy healthy effect generating a less oxidative environment and modulating LOX and COX activities toward a decrease in the production of proinflammatory ARA eicosanoids and oxidative stress biomarkers from EPA and DHA. In addition, the ability of 1:1 and 2:1 fish oil diets to reduce lipid mediator levels was in concurrence with the protective effect exerted by decreasing inflammatory markers as ω-6/ω-3 ratio in plasma and membranes. It was also highlighted the effect of a higher DHA amount in the diet reducing the healthy benefits described in terms of inflammation and oxidative stress. Results support the antiinflammatory and antioxidative role of fish oils and, particularly, the effect of adequate proportions EPA:DHAThis work was supported by the Spanish Ministerio de Economía y Competitividad (AGL2013-49079-C2-1-R). The Consejo Superior de Investigaciones Científicas (CSIC) and the University of Santiago de Compostela are gratefully acknowledged for the doctoral fellowship to G.D. Xunta de Galicia and European Social Fund are also thankfully recognized by the financial support of the postdoctoral “Isidro Parga Pondal” contract to M.P and “Jae-Doc” contract to E.G.-EPeer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/124697reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-49079-C2-1-Rhttp://dx.doi.org/10.1016/j.jnutbio.2015.07.007Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1246972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
title Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
spellingShingle Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
Dasilva, Gabriel
Lipid mediators
Fish oil
EPA
DHA
Oxidative stress
Inflammation
title_short Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
title_full Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
title_fullStr Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
title_full_unstemmed Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
title_sort Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation
dc.creator.none.fl_str_mv Dasilva, Gabriel
Pazos Palmeiro, Manuel
García-Egido, Eduardo
Gallardo, José Manuel
Rodríguez, Isaac
Cela, Rafael
Medina, Isabel
author Dasilva, Gabriel
author_facet Dasilva, Gabriel
Pazos Palmeiro, Manuel
García-Egido, Eduardo
Gallardo, José Manuel
Rodríguez, Isaac
Cela, Rafael
Medina, Isabel
author_role author
author2 Pazos Palmeiro, Manuel
García-Egido, Eduardo
Gallardo, José Manuel
Rodríguez, Isaac
Cela, Rafael
Medina, Isabel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lipid mediators
Fish oil
EPA
DHA
Oxidative stress
Inflammation
topic Lipid mediators
Fish oil
EPA
DHA
Oxidative stress
Inflammation
description 8 páginas, 4 tablas, 1 figura
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/124697
url http://hdl.handle.net/10261/124697
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-49079-C2-1-R
http://dx.doi.org/10.1016/j.jnutbio.2015.07.007
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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