Genomic Understanding of an Infectious Brain Disease from the Desert

Rhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individual...

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Autores: Moreno, Leandro F., Ahmed, Abdalla A. O., Brankovics, Balázs, Cuomo, Christina A., Menken, Steph B. J., Taj-Aldeen, Saad J., Faidah, Hani, Stielow, J. Benjamin, Teixeira, Marcus de M., Prenafeta-Boldú, Francesc X., Vicente, Vania A., de Hoog, Sybren
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12327/61
Acceso en línea:http://hdl.handle.net/20.500.12327/61
https://doi.org/10.1534/g3.117.300421
Access Level:acceso abierto
Palabra clave:616.8 - Neurologia. Neuropatologia. Sistema nerviós
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spelling Genomic Understanding of an Infectious Brain Disease from the DesertMoreno, Leandro F.Ahmed, Abdalla A. O.Brankovics, BalázsCuomo, Christina A.Menken, Steph B. J.Taj-Aldeen, Saad J.Faidah, HaniStielow, J. BenjaminTeixeira, Marcus de M.Prenafeta-Boldú, Francesc X.Vicente, Vania A.de Hoog, Sybren616.8 - Neurologia. Neuropatologia. Sistema nerviósRhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper, we describe the whole-genome resequencing of two R. mackenziei strains from patients in Saudi Arabia and Qatar. We assessed intraspecies variation and genetic signatures to uncover the genomic basis of the pathogenesis, and potential niche adaptations. We found that the duplicated genes (paralogs) are more susceptible to accumulating significant mutations. Comparative genomics with other filamentous ascomycetes revealed a diverse arsenal of genes likely engaged in pathogenicity, such as the degradation of aromatic compounds and iron acquisition. In addition, intracellular accumulation of trehalose and choline suggests possible adaptations to the conditions of an arid climate region. Specifically, protein family contractions were found, including short-chain dehydrogenase/reductase SDR, the cytochrome P450 (CYP) (E-class), and the G-protein b WD-40 repeat. Gene composition and metabolic potential indicate extremotolerance and hydrocarbon assimilation, suggesting a possible environmental habitat of oil-polluted desert soilinfo:eu-repo/semantics/publishedVersionGenetics Society of AmericaProducció AnimalSostenibilitat en Biosistemes2018info:eu-repo/semantics/article14http://hdl.handle.net/20.500.12327/61https://doi.org/10.1534/g3.117.300421reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésG3: Genes, Genomes, GeneticsAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12327/612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genomic Understanding of an Infectious Brain Disease from the Desert
title Genomic Understanding of an Infectious Brain Disease from the Desert
spellingShingle Genomic Understanding of an Infectious Brain Disease from the Desert
Moreno, Leandro F.
616.8 - Neurologia. Neuropatologia. Sistema nerviós
title_short Genomic Understanding of an Infectious Brain Disease from the Desert
title_full Genomic Understanding of an Infectious Brain Disease from the Desert
title_fullStr Genomic Understanding of an Infectious Brain Disease from the Desert
title_full_unstemmed Genomic Understanding of an Infectious Brain Disease from the Desert
title_sort Genomic Understanding of an Infectious Brain Disease from the Desert
dc.creator.none.fl_str_mv Moreno, Leandro F.
Ahmed, Abdalla A. O.
Brankovics, Balázs
Cuomo, Christina A.
Menken, Steph B. J.
Taj-Aldeen, Saad J.
Faidah, Hani
Stielow, J. Benjamin
Teixeira, Marcus de M.
Prenafeta-Boldú, Francesc X.
Vicente, Vania A.
de Hoog, Sybren
author Moreno, Leandro F.
author_facet Moreno, Leandro F.
Ahmed, Abdalla A. O.
Brankovics, Balázs
Cuomo, Christina A.
Menken, Steph B. J.
Taj-Aldeen, Saad J.
Faidah, Hani
Stielow, J. Benjamin
Teixeira, Marcus de M.
Prenafeta-Boldú, Francesc X.
Vicente, Vania A.
de Hoog, Sybren
author_role author
author2 Ahmed, Abdalla A. O.
Brankovics, Balázs
Cuomo, Christina A.
Menken, Steph B. J.
Taj-Aldeen, Saad J.
Faidah, Hani
Stielow, J. Benjamin
Teixeira, Marcus de M.
Prenafeta-Boldú, Francesc X.
Vicente, Vania A.
de Hoog, Sybren
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Sostenibilitat en Biosistemes
dc.subject.none.fl_str_mv 616.8 - Neurologia. Neuropatologia. Sistema nerviós
topic 616.8 - Neurologia. Neuropatologia. Sistema nerviós
description Rhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper, we describe the whole-genome resequencing of two R. mackenziei strains from patients in Saudi Arabia and Qatar. We assessed intraspecies variation and genetic signatures to uncover the genomic basis of the pathogenesis, and potential niche adaptations. We found that the duplicated genes (paralogs) are more susceptible to accumulating significant mutations. Comparative genomics with other filamentous ascomycetes revealed a diverse arsenal of genes likely engaged in pathogenicity, such as the degradation of aromatic compounds and iron acquisition. In addition, intracellular accumulation of trehalose and choline suggests possible adaptations to the conditions of an arid climate region. Specifically, protein family contractions were found, including short-chain dehydrogenase/reductase SDR, the cytochrome P450 (CYP) (E-class), and the G-protein b WD-40 repeat. Gene composition and metabolic potential indicate extremotolerance and hydrocarbon assimilation, suggesting a possible environmental habitat of oil-polluted desert soil
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/61
https://doi.org/10.1534/g3.117.300421
url http://hdl.handle.net/20.500.12327/61
https://doi.org/10.1534/g3.117.300421
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv G3: Genes, Genomes, Genetics
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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