Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study

Perez-Sáez, MJ; Melilli, E; Arias, M; Franco, A; Martinez, R; Sancho, A; Molina, M; Facundo, C; Polanco, N; López, V; Mazuecos, A; Cabello, S; García, MEG; Suárez, ML; Auyanet, I; Espi, J; Falcón, TG; Ruiz, JC; Galeano, C; Artamendi, M; Rodríguez-Ferrero, ML; Portolés, JM; Santana, MA; Martín-Moreno, PL; Arhda, N; Calvo, M; Mendiluce, A; Macía, M; Pérez-Tamajón, ML; de Teresa, J; Gascó, B; Soriano, S; Tabernero, G; de la Vara, L; Ramos, AM; Martínez, R; de Espinosa, EM; Zalve, JL; Pascual, J; Rodriguez-Mañas, L; Gutiérrez-Dalmau, A; Moreso, F

Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study

Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc >= 50 years. Frailty...

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Autores:	Perez-Sáez, MJ, Melilli, E, Arias, M, Franco, A, Martinez, R, Sancho, A, Molina, M, Facundo, C, Polanco, N, López, V, Mazuecos, A, Cabello, S, García, MEG, Suárez, ML, Auyanet, I, Espi, J, Falcón, TG, Ruiz, JC, Galeano, C, Artamendi, M, Rodríguez-Ferrero, ML, Portolés, JM, Santana, MA, Martín-Moreno, PL, Arhda, N, Calvo, M, Mendiluce, A, Macía, M, Pérez-Tamajón, ML, de Teresa, J, Gascó, B, Soriano, S, Tabernero, G, de la Vara, L, Ramos, AM, Martínez, R, de Espinosa, EM, Zalve, JL, Pascual, J, Rodriguez-Mañas, L, Gutiérrez-Dalmau, A, Moreso, F
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p19715
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19715
Access Level:	acceso abierto
Palabra clave:	FRAIL frailty kidney transplant waiting list candidate

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spelling	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter StudyPerez-Sáez, MJMelilli, EArias, MFranco, AMartinez, RSancho, AMolina, MFacundo, CPolanco, NLópez, VMazuecos, ACabello, SGarcía, MEGSuárez, MLAuyanet, IEspi, JFalcón, TGRuiz, JCGaleano, CArtamendi, MRodríguez-Ferrero, MLPortolés, JMSantana, MAMartín-Moreno, PLArhda, NCalvo, MMendiluce, AMacía, MPérez-Tamajón, MLde Teresa, JGascó, BSoriano, STabernero, Gde la Vara, LRamos, AMMartínez, Rde Espinosa, EMZalve, JLPascual, JRodriguez-Mañas, LGutiérrez-Dalmau, AMoreso, FFRAILfrailtykidney transplantwaiting listcandidateFrailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc >= 50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4-7] and the total number of medications was 9 [7-12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5-6.2]); higher CCI (>6 OR 2.9 [1.6-54]); and the number of medications (OR -per medication- 1.13 [1.07-1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19715TRANSPLANT INTERNATIONALISSN: 09340874ISSNe: 14322277reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p197152026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
title	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
spellingShingle	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study Perez-Sáez, MJ FRAIL frailty kidney transplant waiting list candidate
title_short	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
title_full	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
title_fullStr	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
title_full_unstemmed	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
title_sort	Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
dc.creator.none.fl_str_mv	Perez-Sáez, MJ Melilli, E Arias, M Franco, A Martinez, R Sancho, A Molina, M Facundo, C Polanco, N López, V Mazuecos, A Cabello, S García, MEG Suárez, ML Auyanet, I Espi, J Falcón, TG Ruiz, JC Galeano, C Artamendi, M Rodríguez-Ferrero, ML Portolés, JM Santana, MA Martín-Moreno, PL Arhda, N Calvo, M Mendiluce, A Macía, M Pérez-Tamajón, ML de Teresa, J Gascó, B Soriano, S Tabernero, G de la Vara, L Ramos, AM Martínez, R de Espinosa, EM Zalve, JL Pascual, J Rodriguez-Mañas, L Gutiérrez-Dalmau, A Moreso, F
author	Perez-Sáez, MJ
author_facet	Perez-Sáez, MJ Melilli, E Arias, M Franco, A Martinez, R Sancho, A Molina, M Facundo, C Polanco, N López, V Mazuecos, A Cabello, S García, MEG Suárez, ML Auyanet, I Espi, J Falcón, TG Ruiz, JC Galeano, C Artamendi, M Rodríguez-Ferrero, ML Portolés, JM Santana, MA Martín-Moreno, PL Arhda, N Calvo, M Mendiluce, A Macía, M Pérez-Tamajón, ML de Teresa, J Gascó, B Soriano, S Tabernero, G de la Vara, L Ramos, AM Martínez, R de Espinosa, EM Zalve, JL Pascual, J Rodriguez-Mañas, L Gutiérrez-Dalmau, A Moreso, F
author_role	author
author2	Melilli, E Arias, M Franco, A Martinez, R Sancho, A Molina, M Facundo, C Polanco, N López, V Mazuecos, A Cabello, S García, MEG Suárez, ML Auyanet, I Espi, J Falcón, TG Ruiz, JC Galeano, C Artamendi, M Rodríguez-Ferrero, ML Portolés, JM Santana, MA Martín-Moreno, PL Arhda, N Calvo, M Mendiluce, A Macía, M Pérez-Tamajón, ML de Teresa, J Gascó, B Soriano, S Tabernero, G de la Vara, L Ramos, AM Martínez, R de Espinosa, EM Zalve, JL Pascual, J Rodriguez-Mañas, L Gutiérrez-Dalmau, A Moreso, F
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	FRAIL frailty kidney transplant waiting list candidate
topic	FRAIL frailty kidney transplant waiting list candidate
description	Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc >= 50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4-7] and the total number of medications was 9 [7-12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5-6.2]); higher CCI (>6 OR 2.9 [1.6-54]); and the number of medications (OR -per medication- 1.13 [1.07-1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.
publishDate	2025
dc.date.none.fl_str_mv	2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19715
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19715
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	WILEY
publisher.none.fl_str_mv	WILEY
dc.source.none.fl_str_mv	TRANSPLANT INTERNATIONAL ISSN: 09340874 ISSNe: 14322277 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study

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