Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective

Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is a sustainable model to overcome curre...

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Detalles Bibliográficos
Autores: Cortés Díaz, Jesús María, De Petris, Giovanni, López, José I.
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/27269
Acceso en línea:http://hdl.handle.net/10810/27269
Access Level:acceso abierto
Palabra clave:tumor sampling
intratumor heterogeneity
stomach
large bowel
urinary bladder
in silico modeling
familial gastric-cancer
colorectal-cancer
urinary-bladder
renal pelvis
carcinoma
specimens
recommendations
evolution
invasion
ureter
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spelling Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling PerspectiveCortés Díaz, Jesús MaríaDe Petris, GiovanniLópez, José I.tumor samplingintratumor heterogeneitystomachlarge bowelurinary bladderin silico modelingfamilial gastric-cancercolorectal-cancerurinary-bladderrenal pelviscarcinomaspecimensrecommendationsevolutioninvasionureterCurrent sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is a sustainable model to overcome current deficiencies in digestive and bladder tumors when they are large enough so as to make unaffordable a total sampling. The new method is based on the divide-and-conquer algorithm and includes a slight modification of the MSTS, which proved to be useful very recently in clear cell renal cell carcinoma. This in silico analysis confirms the usefulness of MSTS for detecting intratumor heterogeneity (ITH) in tumors arising in hollow viscera. However, MSTS does not seem to improve routine traditional sampling in detecting tumor budding, extramural venous invasion, and perineural invasion. We conclude that (1) MSTS is the best method for tumor sampling to detect ITH balancing high performance and sustainable cost, (2) MSTS must be adapted to tumor shape and tumor location for an optimal performance.JC acknowledges financial support from Ikerbasque: The Basque Foundation for Science. This work was partially funded by grant SAF2013-48812-R from Ministerio de Economia y Competitividad (Spain) to JL; grant DPI2016-79874-R from Ministerio Economia y Competitividad (Spain) and FEDER to JC.Frontiers Media201820182017info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/27269reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/SAF2013-48812-R/info:eu-repo/grantAgreement/MINECO/DPI2016-79874-R/https://www.frontiersin.org/articles/10.3389/fmed.2017.00025/fullinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/Copyright: © 2017 Cortés, de Petris and López. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/272692026-06-18T09:23:17Z
dc.title.none.fl_str_mv Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
title Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
spellingShingle Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
Cortés Díaz, Jesús María
tumor sampling
intratumor heterogeneity
stomach
large bowel
urinary bladder
in silico modeling
familial gastric-cancer
colorectal-cancer
urinary-bladder
renal pelvis
carcinoma
specimens
recommendations
evolution
invasion
ureter
title_short Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
title_full Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
title_fullStr Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
title_full_unstemmed Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
title_sort Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective
dc.creator.none.fl_str_mv Cortés Díaz, Jesús María
De Petris, Giovanni
López, José I.
author Cortés Díaz, Jesús María
author_facet Cortés Díaz, Jesús María
De Petris, Giovanni
López, José I.
author_role author
author2 De Petris, Giovanni
López, José I.
author2_role author
author
dc.subject.none.fl_str_mv tumor sampling
intratumor heterogeneity
stomach
large bowel
urinary bladder
in silico modeling
familial gastric-cancer
colorectal-cancer
urinary-bladder
renal pelvis
carcinoma
specimens
recommendations
evolution
invasion
ureter
topic tumor sampling
intratumor heterogeneity
stomach
large bowel
urinary bladder
in silico modeling
familial gastric-cancer
colorectal-cancer
urinary-bladder
renal pelvis
carcinoma
specimens
recommendations
evolution
invasion
ureter
description Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is a sustainable model to overcome current deficiencies in digestive and bladder tumors when they are large enough so as to make unaffordable a total sampling. The new method is based on the divide-and-conquer algorithm and includes a slight modification of the MSTS, which proved to be useful very recently in clear cell renal cell carcinoma. This in silico analysis confirms the usefulness of MSTS for detecting intratumor heterogeneity (ITH) in tumors arising in hollow viscera. However, MSTS does not seem to improve routine traditional sampling in detecting tumor budding, extramural venous invasion, and perineural invasion. We conclude that (1) MSTS is the best method for tumor sampling to detect ITH balancing high performance and sustainable cost, (2) MSTS must be adapted to tumor shape and tumor location for an optimal performance.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/27269
url http://hdl.handle.net/10810/27269
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/SAF2013-48812-R/
info:eu-repo/grantAgreement/MINECO/DPI2016-79874-R/
https://www.frontiersin.org/articles/10.3389/fmed.2017.00025/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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