Antimicrobial Peptides with Anti-Candida Activity

[EN] Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. Candida albicans remains the prevalent etiologic agent, but the incidence of other species such as Candida parapsilosis, Candida glabrata and C...

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Autores: Pérez Rodríguez, Aitzol, Eraso Barrio, María Elena, Quindós Andrés, Guillermo, Mateo Alesanco, Estibaliz
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57357
Acceso en línea:http://hdl.handle.net/10810/57357
Access Level:acceso abierto
Palabra clave:fungal infections
candidiasis
microbial resistance
antifungal peptides
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spelling Antimicrobial Peptides with Anti-Candida ActivityPérez Rodríguez, AitzolEraso Barrio, María ElenaQuindós Andrés, GuillermoMateo Alesanco, Estibalizfungal infectionscandidiasismicrobial resistanceantifungal peptides[EN] Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. Candida albicans remains the prevalent etiologic agent, but the incidence of other species such as Candida parapsilosis, Candida glabrata and Candida auris keeps increasing. These pathogens frequently show a reduced susceptibility to commonly used antifungal drugs, including polyenes, triazoles and echinocandins, and the incidence of emerging multi-drug-resistant strains of these species continues to increase. Therefore, the need to search for new molecules that target these pathogenic species in a different manner is now more urgent than ever. Nature is an almost endless source of interesting new molecules that could meet this need. Among these molecules, antimicrobial peptides, present in different sources in nature, possess some advantages over conventional antifungal agents, even with their own drawbacks, and are considered as a promising pharmacological option against a wide range of microbial infections. In this review, we describe 20 antimicrobial peptides from different origins that possess an activity against Candida.This research was funded by the Spanish Ministry of Science and Innovation (PID2020-117983RB-I00) and by the Consejería de Educación, Universidades e Investigación of Gobierno Vasco-Eusko Jaurlaritza (IT1607-22). A.P.-R. was funded by a Ph.D. grant from the University of the Basque Country (PIF17/167).MDPI2022202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/57357reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2020-117983RB-I00/https://www.mdpi.com/1422-0067/23/16/9264info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).oai:addi.ehu.eus:10810/573572026-06-18T09:23:17Z
dc.title.none.fl_str_mv Antimicrobial Peptides with Anti-Candida Activity
title Antimicrobial Peptides with Anti-Candida Activity
spellingShingle Antimicrobial Peptides with Anti-Candida Activity
Pérez Rodríguez, Aitzol
fungal infections
candidiasis
microbial resistance
antifungal peptides
title_short Antimicrobial Peptides with Anti-Candida Activity
title_full Antimicrobial Peptides with Anti-Candida Activity
title_fullStr Antimicrobial Peptides with Anti-Candida Activity
title_full_unstemmed Antimicrobial Peptides with Anti-Candida Activity
title_sort Antimicrobial Peptides with Anti-Candida Activity
dc.creator.none.fl_str_mv Pérez Rodríguez, Aitzol
Eraso Barrio, María Elena
Quindós Andrés, Guillermo
Mateo Alesanco, Estibaliz
author Pérez Rodríguez, Aitzol
author_facet Pérez Rodríguez, Aitzol
Eraso Barrio, María Elena
Quindós Andrés, Guillermo
Mateo Alesanco, Estibaliz
author_role author
author2 Eraso Barrio, María Elena
Quindós Andrés, Guillermo
Mateo Alesanco, Estibaliz
author2_role author
author
author
dc.subject.none.fl_str_mv fungal infections
candidiasis
microbial resistance
antifungal peptides
topic fungal infections
candidiasis
microbial resistance
antifungal peptides
description [EN] Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. Candida albicans remains the prevalent etiologic agent, but the incidence of other species such as Candida parapsilosis, Candida glabrata and Candida auris keeps increasing. These pathogens frequently show a reduced susceptibility to commonly used antifungal drugs, including polyenes, triazoles and echinocandins, and the incidence of emerging multi-drug-resistant strains of these species continues to increase. Therefore, the need to search for new molecules that target these pathogenic species in a different manner is now more urgent than ever. Nature is an almost endless source of interesting new molecules that could meet this need. Among these molecules, antimicrobial peptides, present in different sources in nature, possess some advantages over conventional antifungal agents, even with their own drawbacks, and are considered as a promising pharmacological option against a wide range of microbial infections. In this review, we describe 20 antimicrobial peptides from different origins that possess an activity against Candida.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/57357
url http://hdl.handle.net/10810/57357
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2020-117983RB-I00/
https://www.mdpi.com/1422-0067/23/16/9264
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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