Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts

[Background] Sos1 and Sos2 are guanine-nucleotide exchange factors for Ras and Rac small GTPases, which are involved in a wide range of cellular responses including proliferation and migration. We have previously shown that Sos1 and Sos2 have different effects on cell migration, but the underlying m...

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Detalles Bibliográficos
Autores: Liceras-Boillos, Pilar, García-Navas, Rósula, Llorente-González, Clara, Lorenzo-Martín, L. Francisco, Luna Ramírez, Luis, Fuentes Mateos, Rocío, Calzada, Nuria, Vega, Francisco M., Holt, Mark R., Ridley, Anne J., Bustelo, Xosé R., Vicente-Manzanares, Miguel, Santos de Dios, Eugenio, Baltanás, Fernando C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/390427
Acceso en línea:http://hdl.handle.net/10261/390427
https://api.elsevier.com/content/abstract/scopus_id/86000100100
Access Level:acceso abierto
Palabra clave:Migration
Mmp2/9
Rac
Ras
RasGEF
Sos1
Sos2
Descripción
Sumario:[Background] Sos1 and Sos2 are guanine-nucleotide exchange factors for Ras and Rac small GTPases, which are involved in a wide range of cellular responses including proliferation and migration. We have previously shown that Sos1 and Sos2 have different effects on cell migration, but the underlying mechanisms are not clear.

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