Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis

246 p.

Detalhes bibliográficos
Autor: Durá Esteve, Irene
Formato: tesis doctoral
Fecha de publicación:2023
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/59617
Acesso em linha:http://hdl.handle.net/10810/59617
Access Level:acceso abierto
Palavra-chave:neurophysiology
neurofisiología
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spelling Traumatic Brain Injury-induced alterations in Adult Hippocampal NeurogenesisDurá Esteve, Ireneneurophysiologyneurofisiología246 p.Several important cognitive functions affected by traumatic brain injury (TBI) depend on the hippocampus, which harnesses several forms of neural plasticity, among them adult neurogenesis, the generation of new neurons throughout life. Adult hippocampal neurogenesis is a process involved in memory, learning and control of anxiety, cognitive functions which result impaired after TBI. We hypothesize that TBI induces fast and long-term changes in both neural stem cells (NSCs) and newborn neurons which could subsequently alter hippocampal and brain functioning. Using a model of controlled cortical impact (CCI) we have found that TBI has a dual effect on neurogenesis: In the short term (up to two months) it causes an increase in the number of newborn neurons but with aberrant migration, increased soma size and altered electrophysiological properties; in the long term, neurogenesis resultsimpaired by a reduction in the number of immature neurons. We also suggest that the alteration in the expression of Rho Family GTPase 2 (Rnd2) could be causing some of the morphological changes in the immature neurons as well as their aberrant migration and thus could be a target to prevent TBI-induced aberrant neurogenesis, a hypothesis that we are currently investigating at the cellular level. In addition, we have found that NSCs get activated in higher numbers early after TBI, a result that could explain the later reduction in neurogenesis.Pineda Martí, José RamónEncinas Pérez, Juan Manuel2023202320232023info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10810/59617reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Atribución-NoComercial-SinDerivadas 3.0 España(cc)2023 IRENE DURA ESTEVE (cc by-nc-nd 4.0)oai:addi.ehu.eus:10810/596172026-06-18T09:23:17Z
dc.title.none.fl_str_mv Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
title Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
spellingShingle Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
Durá Esteve, Irene
neurophysiology
neurofisiología
title_short Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
title_full Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
title_fullStr Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
title_full_unstemmed Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
title_sort Traumatic Brain Injury-induced alterations in Adult Hippocampal Neurogenesis
dc.creator.none.fl_str_mv Durá Esteve, Irene
author Durá Esteve, Irene
author_facet Durá Esteve, Irene
author_role author
dc.contributor.none.fl_str_mv Pineda Martí, José Ramón
Encinas Pérez, Juan Manuel
dc.subject.none.fl_str_mv neurophysiology
neurofisiología
topic neurophysiology
neurofisiología
description 246 p.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/59617
url http://hdl.handle.net/10810/59617
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
(cc)2023 IRENE DURA ESTEVE (cc by-nc-nd 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
(cc)2023 IRENE DURA ESTEVE (cc by-nc-nd 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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