Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode
Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:291484 |
| Acceso en línea: | https://ddd.uab.cat/record/291484 https://dx.doi.org/urn:doi:10.1017/S0033291722001544 |
| Access Level: | acceso abierto |
| Palabra clave: | Cognition Early stages First-episode psychosis Genetics Polygenic risk score Schizophrenia |
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Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episodeSegura, Alex G.|||0000-0002-9398-2183Mezquida, Gisela|||0000-0002-6080-2203Martínez Piñeiro, Alberto|||0000-0003-2035-5979Gassó, Patricia|||0000-0001-6930-3454Rodriguez, NataliaMoreno-Izco, LucíaAmoretti, Silvia|||0000-0001-6017-2734Bioque, Miquel|||0000-0001-6887-7149Lobo, Antonio|||0000-0002-9098-655XGonzález-Pinto, Ana|||0000-0002-2568-5179García-Alcon, Alicia|||0000-0003-1777-1795Roldan-Bejarano, Alexandra|||0000-0001-9905-3943Vieta, Eduard|||0000-0002-0548-0053de la Serna, Elena|||0000-0002-7869-9881Toll, Alba|||0000-0003-2399-5250Cuesta, Manuel J.|||0000-0003-0250-5718Mas, Sergi|||0000-0003-3336-6298Bernardo, Miquel|||0000-0001-8748-6717CognitionEarly stagesFirst-episode psychosisGeneticsPolygenic risk scoreSchizophreniaClinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes are required to unravel the mechanisms underlying the early progression of the disorder. The sample comprised of 233 first-episode psychosis (FEP) subjects with clinical and cognitive data assessed periodically for a 2-year period and 150 matched controls. Polygenic risk scores (PRSs) for schizophrenia, bipolar disorder, depression, education attainment and cognitive performance were used to assess the genetic risk of FEP and to characterize their association with premorbid, baseline and progression of clinical and cognitive status. Schizophrenia, bipolar disorder and cognitive performance PRSs were associated with an increased risk of FEP [false discovery rate (FDR) ⩽ 0.027]. In FEP patients, increased cognitive PRSs were found for FEP patients with more cognitive reserve (FDR ⩽ 0.037). PRSs reflecting a genetic liability for improved cognition were associated with a better course of symptoms, functionality and working memory (FDR ⩽ 0.039). Moreover, the PRS of depression was associated with a worse trajectory of the executive function and the general cognitive status (FDR ⩽ 0.001). Our study provides novel evidence of the polygenic bases of psychosis and its clinical manifestation in its first stage. The consistent effect of cognitive PRSs on the early clinical progression suggests that the mechanisms underlying the psychotic episode and its severity could be partially independent.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/291484https://dx.doi.org/urn:doi:10.1017/S0033291722001544reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00325Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01055Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00612open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2914842026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| title |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| spellingShingle |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode Segura, Alex G.|||0000-0002-9398-2183 Cognition Early stages First-episode psychosis Genetics Polygenic risk score Schizophrenia |
| title_short |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| title_full |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| title_fullStr |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| title_full_unstemmed |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| title_sort |
Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode |
| dc.creator.none.fl_str_mv |
Segura, Alex G.|||0000-0002-9398-2183 Mezquida, Gisela|||0000-0002-6080-2203 Martínez Piñeiro, Alberto|||0000-0003-2035-5979 Gassó, Patricia|||0000-0001-6930-3454 Rodriguez, Natalia Moreno-Izco, Lucía Amoretti, Silvia|||0000-0001-6017-2734 Bioque, Miquel|||0000-0001-6887-7149 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 García-Alcon, Alicia|||0000-0003-1777-1795 Roldan-Bejarano, Alexandra|||0000-0001-9905-3943 Vieta, Eduard|||0000-0002-0548-0053 de la Serna, Elena|||0000-0002-7869-9881 Toll, Alba|||0000-0003-2399-5250 Cuesta, Manuel J.|||0000-0003-0250-5718 Mas, Sergi|||0000-0003-3336-6298 Bernardo, Miquel|||0000-0001-8748-6717 |
| author |
Segura, Alex G.|||0000-0002-9398-2183 |
| author_facet |
Segura, Alex G.|||0000-0002-9398-2183 Mezquida, Gisela|||0000-0002-6080-2203 Martínez Piñeiro, Alberto|||0000-0003-2035-5979 Gassó, Patricia|||0000-0001-6930-3454 Rodriguez, Natalia Moreno-Izco, Lucía Amoretti, Silvia|||0000-0001-6017-2734 Bioque, Miquel|||0000-0001-6887-7149 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 García-Alcon, Alicia|||0000-0003-1777-1795 Roldan-Bejarano, Alexandra|||0000-0001-9905-3943 Vieta, Eduard|||0000-0002-0548-0053 de la Serna, Elena|||0000-0002-7869-9881 Toll, Alba|||0000-0003-2399-5250 Cuesta, Manuel J.|||0000-0003-0250-5718 Mas, Sergi|||0000-0003-3336-6298 Bernardo, Miquel|||0000-0001-8748-6717 |
| author_role |
author |
| author2 |
Mezquida, Gisela|||0000-0002-6080-2203 Martínez Piñeiro, Alberto|||0000-0003-2035-5979 Gassó, Patricia|||0000-0001-6930-3454 Rodriguez, Natalia Moreno-Izco, Lucía Amoretti, Silvia|||0000-0001-6017-2734 Bioque, Miquel|||0000-0001-6887-7149 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 García-Alcon, Alicia|||0000-0003-1777-1795 Roldan-Bejarano, Alexandra|||0000-0001-9905-3943 Vieta, Eduard|||0000-0002-0548-0053 de la Serna, Elena|||0000-0002-7869-9881 Toll, Alba|||0000-0003-2399-5250 Cuesta, Manuel J.|||0000-0003-0250-5718 Mas, Sergi|||0000-0003-3336-6298 Bernardo, Miquel|||0000-0001-8748-6717 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cognition Early stages First-episode psychosis Genetics Polygenic risk score Schizophrenia |
| topic |
Cognition Early stages First-episode psychosis Genetics Polygenic risk score Schizophrenia |
| description |
Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes are required to unravel the mechanisms underlying the early progression of the disorder. The sample comprised of 233 first-episode psychosis (FEP) subjects with clinical and cognitive data assessed periodically for a 2-year period and 150 matched controls. Polygenic risk scores (PRSs) for schizophrenia, bipolar disorder, depression, education attainment and cognitive performance were used to assess the genetic risk of FEP and to characterize their association with premorbid, baseline and progression of clinical and cognitive status. Schizophrenia, bipolar disorder and cognitive performance PRSs were associated with an increased risk of FEP [false discovery rate (FDR) ⩽ 0.027]. In FEP patients, increased cognitive PRSs were found for FEP patients with more cognitive reserve (FDR ⩽ 0.037). PRSs reflecting a genetic liability for improved cognition were associated with a better course of symptoms, functionality and working memory (FDR ⩽ 0.039). Moreover, the PRS of depression was associated with a worse trajectory of the executive function and the general cognitive status (FDR ⩽ 0.001). Our study provides novel evidence of the polygenic bases of psychosis and its clinical manifestation in its first stage. The consistent effect of cognitive PRSs on the early clinical progression suggests that the mechanisms underlying the psychotic episode and its severity could be partially independent. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/291484 https://dx.doi.org/urn:doi:10.1017/S0033291722001544 |
| url |
https://ddd.uab.cat/record/291484 https://dx.doi.org/urn:doi:10.1017/S0033291722001544 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00325 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01055 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00612 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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