Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

Santos García, Diego; De Deus Fonticoba, Teresa; Paz González, Jose; Cores Bartolomé, Carlos; Valdés Aymerich, Lorena; Muñoz Enríquez, J. G.; Suárez, Ester; Jesús, Silvia; Aguilar, Miquel; Pastor, Pau; Planellas, Lluís; Cosgaya, Marina; García Caldentey, Juan; Caballol, Núria; Legarda, Ines; Hernández Vara, Jorge; Cabo, Iria; López Manzanares, Lydia; González Aramburu, Isabel; Ávila Rivera, Maria Asunción; Catalán, María José; Nogueira, Víctor; Puente, Víctor; García Moreno, Jose Manuel; Borrué, Carmen; Solano Vila, Berta; Álvarez Sauco, Maria; Vela, Lydia; Escalante Arroyo, Sonia; Cubo, Esther; Carrillo Padilla, Francisco; Martínez Castrillo, Juan; Sánchez Alonso, Pilar; Alonso Losada, Maria Gema; López Ariztegui, Nuria; Gastón, Itziar; Kulisevsky, Jaime; Blázquez Estrada, Marta; Seijo Martínez, Manuel; Rúiz Martínez, Javier

Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NM...

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Autores:	Santos García, Diego, De Deus Fonticoba, Teresa, Paz González, Jose, Cores Bartolomé, Carlos, Valdés Aymerich, Lorena, Muñoz Enríquez, J. G., Suárez, Ester, Jesús, Silvia, Aguilar, Miquel, Pastor, Pau, Planellas, Lluís, Cosgaya, Marina, García Caldentey, Juan, Caballol, Núria, Legarda, Ines, Hernández Vara, Jorge, Cabo, Iria, López Manzanares, Lydia, González Aramburu, Isabel, Ávila Rivera, Maria Asunción, Catalán, María José, Nogueira, Víctor, Puente, Víctor, García Moreno, Jose Manuel, Borrué, Carmen, Solano Vila, Berta, Álvarez Sauco, Maria, Vela, Lydia, Escalante Arroyo, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martínez Castrillo, Juan, Sánchez Alonso, Pilar, Alonso Losada, Maria Gema, López Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Blázquez Estrada, Marta, Seijo Martínez, Manuel, Rúiz Martínez, Javier
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/180192
Acceso en línea:	https://hdl.handle.net/2445/180192
Access Level:	acceso abierto
Palabra clave:	Malaltia de Parkinson Parkinson's disease

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spelling	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.Santos García, DiegoDe Deus Fonticoba, TeresaPaz González, JoseCores Bartolomé, CarlosValdés Aymerich, LorenaMuñoz Enríquez, J. G.Suárez, EsterJesús, SilviaAguilar, MiquelPastor, PauPlanellas, LluísCosgaya, MarinaGarcía Caldentey, JuanCaballol, NúriaLegarda, InesHernández Vara, JorgeCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, Maria AsunciónCatalán, María JoséNogueira, VíctorPuente, VíctorGarcía Moreno, Jose ManuelBorrué, CarmenSolano Vila, BertaÁlvarez Sauco, MariaVela, LydiaEscalante Arroyo, SoniaCubo, EstherCarrillo Padilla, FranciscoMartínez Castrillo, JuanSánchez Alonso, PilarAlonso Losada, Maria GemaLópez Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeBlázquez Estrada, MartaSeijo Martínez, ManuelRúiz Martínez, JavierMalaltia de ParkinsonParkinson's diseaseIntroduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.Hindawi2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/180192Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1155/2021/8871549Parkinson's Disease, 2021https://doi.org/10.1155/2021/8871549cc-by (c) Santos García, Diego et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1801922026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
title	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
spellingShingle	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life. Santos García, Diego Malaltia de Parkinson Parkinson's disease
title_short	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
title_full	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
title_fullStr	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
title_full_unstemmed	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
title_sort	Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.
dc.creator.none.fl_str_mv	Santos García, Diego De Deus Fonticoba, Teresa Paz González, Jose Cores Bartolomé, Carlos Valdés Aymerich, Lorena Muñoz Enríquez, J. G. Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, María José Nogueira, Víctor Puente, Víctor García Moreno, Jose Manuel Borrué, Carmen Solano Vila, Berta Álvarez Sauco, Maria Vela, Lydia Escalante Arroyo, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso Losada, Maria Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez Estrada, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier
author	Santos García, Diego
author_facet	Santos García, Diego De Deus Fonticoba, Teresa Paz González, Jose Cores Bartolomé, Carlos Valdés Aymerich, Lorena Muñoz Enríquez, J. G. Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, María José Nogueira, Víctor Puente, Víctor García Moreno, Jose Manuel Borrué, Carmen Solano Vila, Berta Álvarez Sauco, Maria Vela, Lydia Escalante Arroyo, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso Losada, Maria Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez Estrada, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier
author_role	author
author2	De Deus Fonticoba, Teresa Paz González, Jose Cores Bartolomé, Carlos Valdés Aymerich, Lorena Muñoz Enríquez, J. G. Suárez, Ester Jesús, Silvia Aguilar, Miquel Pastor, Pau Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria Asunción Catalán, María José Nogueira, Víctor Puente, Víctor García Moreno, Jose Manuel Borrué, Carmen Solano Vila, Berta Álvarez Sauco, Maria Vela, Lydia Escalante Arroyo, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan Sánchez Alonso, Pilar Alonso Losada, Maria Gema López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Blázquez Estrada, Marta Seijo Martínez, Manuel Rúiz Martínez, Javier
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Malaltia de Parkinson Parkinson's disease
topic	Malaltia de Parkinson Parkinson's disease
description	Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/180192
url	https://hdl.handle.net/2445/180192
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1155/2021/8871549 Parkinson's Disease, 2021 https://doi.org/10.1155/2021/8871549
dc.rights.none.fl_str_mv	cc-by (c) Santos García, Diego et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Santos García, Diego et al., 2021 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	16 p. application/pdf
dc.publisher.none.fl_str_mv	Hindawi
publisher.none.fl_str_mv	Hindawi
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

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