Enhanced glycosyl hydrolase production in Aspergillus nidulans using transcription factor engineering approaches
[Background] Engineered fungi are attractive platforms for the production of plant cell wall hydrolytic enzymes which, among other biotechnological applications, are required for the efficient conversion of biomass to glucose and other fermentable sugars. As a fungal model system, Aspergillus nidula...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/110773 |
| Acceso en línea: | http://hdl.handle.net/10261/110773 |
| Access Level: | acceso abierto |
| Palabra clave: | Ambient pH regulation Fungal cell factories PalA/PacC Xylan/xylose regulator (XlnR) XlnR-xlnp expression system Protein production Aspergillus nidulans Plant cell wall degrading enzymes Endo-1,4-β-Xylanase α-L-rhamnosidase |
| Sumario: | [Background] Engineered fungi are attractive platforms for the production of plant cell wall hydrolytic enzymes which, among other biotechnological applications, are required for the efficient conversion of biomass to glucose and other fermentable sugars. As a fungal model system, Aspergillus nidulans provides genetic tools that are of relevance in this context and potentially applicable to industrially important filamentous fungi. The goal of this study is to assess the utility of A. nidulans as a host for recombinant protein production. |
|---|