Reviewing Pseudoloma neurophilia infections in the popular zebrafish model

Zebrafish is a worldwide used animal model to better understand cultured fish species; thus, in the last two decades, zebrafish facilities have been created in many aquaculture research centres. However, and despite the attempts of rigorous aseptic conditions for animal husbandry in wet laboratory f...

Descripción completa

Detalles Bibliográficos
Autores: Caballero-Huertas, Marta, Soto López, Manuel, Ribas, Laia
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/54518
Acceso en línea:http://hdl.handle.net/10810/54518
Access Level:acceso abierto
Palabra clave:aquaculture
immune
infection
parasite
protocol
reproduction
id ES_8d470b3e6ed8ebe5eb5fd749893e2e11
oai_identifier_str oai:addi.ehu.eus:10810/54518
network_acronym_str ES
network_name_str España
repository_id_str
spelling Reviewing Pseudoloma neurophilia infections in the popular zebrafish modelCaballero-Huertas, MartaSoto López, ManuelRibas, LaiaaquacultureimmuneinfectionparasiteprotocolreproductionZebrafish is a worldwide used animal model to better understand cultured fish species; thus, in the last two decades, zebrafish facilities have been created in many aquaculture research centres. However, and despite the attempts of rigorous aseptic conditions for animal husbandry in wet laboratory facilities, the presence of parasites cannot be underestimated. The microsporidium Pseudoloma neurophilia, which mostly affects the central nervous system, has been listed as the most prevalent parasite in reared zebrafish. The emergence of P. neurophilia is usually detected when the individual presents irreversible morphological and/or behavioural symptoms, and consequently, the spread of the disease is inevitable, indicating that the infection is expanded across rearing tanks. This review attempts, for the first time, to collect and discuss the current information on P. neurophilia life cycle, target tissues and symptomatology of the infection occurred in zebrafish. Due to its vertical transmission together with the increasing presence of zebrafish as a model in reproduction-related problems found in aquaculture, it is highlighted, among others, the sexual dimorphism of the pathogenic effects and the possible transgenerational implications of parasitic infections. Further, to date none effective treatments have been described, so here we provide in detail available diagnostic methods, discussing the importance of the early detection, giving safety-rearing recommendations to decrease the presence of P. neurophilia. Our intention is to minimize parasite outbreaks in zebrafish facilities, which, on the one hand, can compromise zebrafish welfare, and on the other hand, could interfere furtively in the resulting research previously designed for improving aquaculture production but also other biomedical-related research.Authors' research funding is supported by the Spanish Ministry of Science and Innovation grants AGL2015-73864-JIN 'Ambisex' and RYC2018-024017-I and by Spanish National Research Council (CSIC) grant 202030E004 'Interomics' to LR. We would like to thank Dr. Francesc Padros from Universitat Autnoma de Barcelona (UAB) for his comments on P. neurophilia infections in zebrafish.Wiley202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/54518reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/AGL2015-73864-JIN/info:eu-repo/grantAgreement/MICINN/RYC2018-024017-I/https://onlinelibrary.wiley.com/doi/10.1111/raq.12545info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2021 The Authors. Reviews in Aquaculture published by John Wiley & Sons Australia, Ltd.1816This is an open access article under the terms of the Creative Commons Attribution License, which permits use,distribution and reproduction in any medium, provided the original work is properly cited.Atribución 3.0 Españaoai:addi.ehu.eus:10810/545182026-06-18T09:23:17Z
dc.title.none.fl_str_mv Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
spellingShingle Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
Caballero-Huertas, Marta
aquaculture
immune
infection
parasite
protocol
reproduction
title_short Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_full Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_fullStr Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_full_unstemmed Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_sort Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
dc.creator.none.fl_str_mv Caballero-Huertas, Marta
Soto López, Manuel
Ribas, Laia
author Caballero-Huertas, Marta
author_facet Caballero-Huertas, Marta
Soto López, Manuel
Ribas, Laia
author_role author
author2 Soto López, Manuel
Ribas, Laia
author2_role author
author
dc.subject.none.fl_str_mv aquaculture
immune
infection
parasite
protocol
reproduction
topic aquaculture
immune
infection
parasite
protocol
reproduction
description Zebrafish is a worldwide used animal model to better understand cultured fish species; thus, in the last two decades, zebrafish facilities have been created in many aquaculture research centres. However, and despite the attempts of rigorous aseptic conditions for animal husbandry in wet laboratory facilities, the presence of parasites cannot be underestimated. The microsporidium Pseudoloma neurophilia, which mostly affects the central nervous system, has been listed as the most prevalent parasite in reared zebrafish. The emergence of P. neurophilia is usually detected when the individual presents irreversible morphological and/or behavioural symptoms, and consequently, the spread of the disease is inevitable, indicating that the infection is expanded across rearing tanks. This review attempts, for the first time, to collect and discuss the current information on P. neurophilia life cycle, target tissues and symptomatology of the infection occurred in zebrafish. Due to its vertical transmission together with the increasing presence of zebrafish as a model in reproduction-related problems found in aquaculture, it is highlighted, among others, the sexual dimorphism of the pathogenic effects and the possible transgenerational implications of parasitic infections. Further, to date none effective treatments have been described, so here we provide in detail available diagnostic methods, discussing the importance of the early detection, giving safety-rearing recommendations to decrease the presence of P. neurophilia. Our intention is to minimize parasite outbreaks in zebrafish facilities, which, on the one hand, can compromise zebrafish welfare, and on the other hand, could interfere furtively in the resulting research previously designed for improving aquaculture production but also other biomedical-related research.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/54518
url http://hdl.handle.net/10810/54518
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/AGL2015-73864-JIN/
info:eu-repo/grantAgreement/MICINN/RYC2018-024017-I/
https://onlinelibrary.wiley.com/doi/10.1111/raq.12545
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413032454520832
score 15.300719

Similares en LA Referencia