Severe Acute Respiratory Syndrome Coronavirus 2 Adaptive Immunity in Nursing Home Residents Following a Third Dose of the Comirnaty Coronavirus Disease 2019 Vaccine

A third Comirnaty® vaccine dose increased SARS-CoV-2-receptor binding domain antibody levels (median of 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (median, 22-fold), Delta, (median, 43-fold) and Omicron (median, 8-fold) variants, particularly in SARS-CoV-2-n...

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Bibliographic Details
Authors: Giménez, Estela, Albert, Eliseo, Zulaica, Joao, Torres, Ignacio, Rusu, Luciana, Rodríguez Moreno, Alicia, Burgos, Javier S., Peiró, Salvador, Salas, Dolores, Vanaclocha, Hermelinda, Limón, Ramón, Alcaraz, María Jesús, Sánchez-Payá, José, Díez-Domingo, Javier, Comas, Iñaki, González-Candelas, Fernando, Geller, Ron, Navarro, David, Valencian Vaccine Research Program (ProVaVac) study group
Format: article
Status:Versión aceptada para publicación
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/269489
Online Access:http://hdl.handle.net/10261/269489
Access Level:Open access
Keyword:SARS-CoV-2
Comirnaty® COVID-19 vaccine third dose
SARS-CoV-2-S antibodies
SARS-CoV-2-S T cells
Neutralizing antibodies
Nursing home residents
Description
Summary:A third Comirnaty® vaccine dose increased SARS-CoV-2-receptor binding domain antibody levels (median of 93-fold) and neutralizing antibody titers against Wuhan-Hu-1 (median, 57-fold), Beta (median, 22-fold), Delta, (median, 43-fold) and Omicron (median, 8-fold) variants, particularly in SARS-CoV-2-naïve individuals, but had a negligible impact on S-reactive T-cell immunity in nursing home residents.

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