Tissue classification for the epidemiological assessment of surgical transmission of sporadic Creutzfeldt-Jakob disease. A proposal on hypothetical risk levels

BACKGROUND: Epidemiological studies on the potential role of surgery in Creutzfeldt-Jakob Disease transmission have disclosed associations with history of specific surgical interventions or reported negative results. METHODS: Within the context of a case-control study designed to address surgical ri...

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Bibliographic Details
Authors: Rábano, Alberto, Pedro-Cuesta, Jesus de, Mølbak, Kåre, Siden, Ake, Calero, Miguel, Laursen, Henning, EUROSURGYCJD Research Group
Format: article
Publication Date:2005
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7078
Online Access:http://hdl.handle.net/20.500.12105/7078
Access Level:Open access
Keyword:Case-Control Studies
Creutzfeldt-Jakob Syndrome
Cross Infection
Denmark
Finland
Humans
PrPSc Proteins
Registries
Risk Assessment
Risk Factors
Sterilization
Surgical Instruments
Surgical Procedures, Operative
Sweden
Tissue Culture Techniques
Equipment Contamination
Description
Summary:BACKGROUND: Epidemiological studies on the potential role of surgery in Creutzfeldt-Jakob Disease transmission have disclosed associations with history of specific surgical interventions or reported negative results. METHODS: Within the context of a case-control study designed to address surgical risk of sporadic Creutzfeldt-Jakob Disease in Nordic European countries (EUROSURGYCJD Project), a strategy was adopted to categorise reported surgical procedures in terms of potential risk of Creutzfeldt-Jakob Disease acquisition. We took into account elements of biological plausibility, either clinically or experimentally demonstrated, such as tissue infectivity, PrP expression content or successful route of infection. RESULTS: We propose a classification of exposed tissues and anatomic structures, drawn up on the basis of their specific putative role as entry site for prion transmission through contact with surgical instruments that are not fully decontaminated. CONCLUSIONS: This classification can serve as a reference, both in our study and in further epidemiological research, for categorisation of surgical procedures in terms of risk level of Creutzfeldt-Jakob Disease acquisition.

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