Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

20 Pág.

Detalles Bibliográficos
Autores: Garcia-Souto, Daniel, Bruzos, Alicia L., Diaz, Seila, Rocha, Sara, Pequeño-Valtierra, Ana, Roman-Lewis, Camila F, Alonso, Juana, Rodriguez, Rosana, Costas, Damian, Rodriguez-Castro, Jorge, Villanueva, Antonio, Valencia, José María, Annona, Giovanni, Tarallo, Andrea, Ricardo, Fernando, Bratoš Cetinić, Ana, Posada, David, Pasantes, Juan Jose, Tubio, Jose Mc, Silva, Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/272643
Acceso en línea:http://hdl.handle.net/10261/272643
https://api.elsevier.com/content/abstract/scopus_id/85123652003
Access Level:acceso abierto
Palabra clave:Cancer biology
Cancer genomes
Ecology
Marine leukaemias
Transmissible cancer
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
spellingShingle Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
Garcia-Souto, Daniel
Cancer biology
Cancer genomes
Ecology
Marine leukaemias
Transmissible cancer
title_short Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_full Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_fullStr Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_full_unstemmed Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_sort Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
dc.creator.none.fl_str_mv Garcia-Souto, Daniel
Bruzos, Alicia L.
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Valencia, José María
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose Mc
Silva, Luis
author Garcia-Souto, Daniel
author_facet Garcia-Souto, Daniel
Bruzos, Alicia L.
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Valencia, José María
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose Mc
Silva, Luis
author_role author
author2 Bruzos, Alicia L.
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Valencia, José María
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose Mc
Silva, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía y Competitividad (España)
Xunta de Galicia
Centro de Estudos do Ambiente e do Mar (Portugal)
Garcia-Souto, Daniel [0000-0002-0997-8799]
Bruzos, Alicia L [0000-0003-4362-545X]
Diaz, Seila [0000-0002-6607-290X]
Rocha, Sara [0000-0002-9705-1511]
Pequeño-Valtierra, Ana [0000-0002-0049-5707]
Roman-Lewis, Camila F [0000-0002-8571-8331]
Costas, Damian [0000-0002-9415-0362]
Rodriguez-Castro, Jorge [0000-0003-2912-9601]
Valencia, José María [0000-0002-1912-1975]
Annona, Giovanni [0000-0001-7806-6761]
Tarallo, Andrea [0000-0002-2749-8588]
Bratoš Cetinić, Ana [0000-0002-2928-4858]
Posada, David [0000-0003-1407-3406]
Pasantes, Juan Jose [0000-0001-6515-3946]
Tubio, Jose Mc [0000-0003-3540-2459]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cancer biology
Cancer genomes
Ecology
Marine leukaemias
Transmissible cancer
topic Cancer biology
Cancer genomes
Ecology
Marine leukaemias
Transmissible cancer
description 20 Pág.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/272643
https://api.elsevier.com/content/abstract/scopus_id/85123652003
url http://hdl.handle.net/10261/272643
https://api.elsevier.com/content/abstract/scopus_id/85123652003
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/MINECO//BES-2016–078166
info:eu-repo/grantAgreement/EC//617457
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106247GB-I00
info:eu-repo/grantAgreement/EC/H2020/730984
eLife
https://doi.org/10.7554/eLife.66946
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern EuropeGarcia-Souto, DanielBruzos, Alicia L.Diaz, SeilaRocha, SaraPequeño-Valtierra, AnaRoman-Lewis, Camila FAlonso, JuanaRodriguez, RosanaCostas, DamianRodriguez-Castro, JorgeVillanueva, AntonioValencia, José MaríaAnnona, GiovanniTarallo, AndreaRicardo, FernandoBratoš Cetinić, AnaPosada, DavidPasantes, Juan JoseTubio, Jose McSilva, LuisCancer biologyCancer genomesEcologyMarine leukaemiasTransmissible cancer20 Pág.Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe.We thank the Galicia Supercomputing Centre (CESGA) for the availability of informatic resources. JMCT, SR, SD, and JT are supported by European Research Council (ERC) Starting Grant 716,290 SCUBA CANCERS. ALB is supported by MINECO PhD fellowship BES-2016-078166. DG-S is supported by postdoctoral contract ED481B/2018/091 from Xunta de Galicia. DP is supported by ERC grant ERC-617457-PHYLOCANCER and by Spanish Ministry of Economy and Competitiveness (MINECO) grant PID2019-106247GB-I00. This research was partially funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement 730984, ASSEMBLE Plus project. CESAM got financial support from FCT/MEC (UIDP/50017/2020, UIDB/50017/2020).Peer reviewedeLife Sciences PublicationsEuropean CommissionMinisterio de Economía y Competitividad (España)Xunta de GaliciaCentro de Estudos do Ambiente e do Mar (Portugal)Garcia-Souto, Daniel [0000-0002-0997-8799]Bruzos, Alicia L [0000-0003-4362-545X]Diaz, Seila [0000-0002-6607-290X]Rocha, Sara [0000-0002-9705-1511]Pequeño-Valtierra, Ana [0000-0002-0049-5707]Roman-Lewis, Camila F [0000-0002-8571-8331]Costas, Damian [0000-0002-9415-0362]Rodriguez-Castro, Jorge [0000-0003-2912-9601]Valencia, José María [0000-0002-1912-1975]Annona, Giovanni [0000-0001-7806-6761]Tarallo, Andrea [0000-0002-2749-8588]Bratoš Cetinić, Ana [0000-0002-2928-4858]Posada, David [0000-0003-1407-3406]Pasantes, Juan Jose [0000-0001-6515-3946]Tubio, Jose Mc [0000-0003-3540-2459]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/272643https://api.elsevier.com/content/abstract/scopus_id/85123652003reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/716290info:eu-repo/grantAgreement/MINECO//BES-2016–078166info:eu-repo/grantAgreement/EC//617457info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106247GB-I00info:eu-repo/grantAgreement/EC/H2020/730984eLifehttps://doi.org/10.7554/eLife.66946Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2726432026-05-22T06:33:51Z
score 15.811543

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