Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations

BACKGROUND: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral...

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Autores: Flores de los Heros, África, 1985-, Herry, Cyril, Maldonado, Rafael, 1961-, Berrendero Díaz, Fernando, 1971-
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/34051
Acesso em linha:http://hdl.handle.net/10230/34051
http://dx.doi.org/10.1093/ijnp/pyx029
Access Level:acceso abierto
Palavra-chave:Fear extinction
Orexin
Amygdala
Retrograde labeling
Calbindin
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spelling Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulationsFlores de los Heros, África, 1985-Herry, CyrilMaldonado, Rafael, 1961-Berrendero Díaz, Fernando, 1971-Fear extinctionOrexinAmygdalaRetrograde labelingCalbindinBACKGROUND: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral amygdala involved in this modulation remain to be elucidated. METHODS: We used retrograde tracing combined with immunofluorescence techniques in mice to identify basolateral amygdala projection neurons and cell subpopulations in this brain region influenced by orexin transmission during contextual fear extinction consolidation. RESULTS: Treatment with the orexin-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin, but not parvalbumin, were also activated by orexin-1 receptor antagonism in the basolateral amygdala. CONCLUSIONS: These data identify neuronal circuits and cell populations of the amygdala associated with the facilitation of fear extinction consolidation induced by the orexin-1 receptor antagonist SB334867.This work was supported by “Plan Nacional sobre Drogas” (no. 2014I019 to F.B.), the “Ministerio de Economía y Competitividad-MINECO” (no. SAF2014-59648-P to R.M.), the “Instituto de Salud Carlos III” (no. PI13/00042 to F.B. and RETICS-RTA, no. RD12/0028/0023 to R.M.), the “Generalitat de Catalunya-AGAUR” (no. 2014-SGR-1547 and ICREA-Acadèmia (2015) to R.M.). AF was recipient of an EMBO Short-Term Fellowship (281-2015).Oxford University Press201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34051http://dx.doi.org/10.1093/ijnp/pyx029reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Neuropsychopharmacology. 2017 Aug 1;20(8):654-9info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P© The Author 2017. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/340512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
title Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
spellingShingle Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
Flores de los Heros, África, 1985-
Fear extinction
Orexin
Amygdala
Retrograde labeling
Calbindin
title_short Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
title_full Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
title_fullStr Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
title_full_unstemmed Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
title_sort Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
dc.creator.none.fl_str_mv Flores de los Heros, África, 1985-
Herry, Cyril
Maldonado, Rafael, 1961-
Berrendero Díaz, Fernando, 1971-
author Flores de los Heros, África, 1985-
author_facet Flores de los Heros, África, 1985-
Herry, Cyril
Maldonado, Rafael, 1961-
Berrendero Díaz, Fernando, 1971-
author_role author
author2 Herry, Cyril
Maldonado, Rafael, 1961-
Berrendero Díaz, Fernando, 1971-
author2_role author
author
author
dc.subject.none.fl_str_mv Fear extinction
Orexin
Amygdala
Retrograde labeling
Calbindin
topic Fear extinction
Orexin
Amygdala
Retrograde labeling
Calbindin
description BACKGROUND: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral amygdala involved in this modulation remain to be elucidated. METHODS: We used retrograde tracing combined with immunofluorescence techniques in mice to identify basolateral amygdala projection neurons and cell subpopulations in this brain region influenced by orexin transmission during contextual fear extinction consolidation. RESULTS: Treatment with the orexin-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin, but not parvalbumin, were also activated by orexin-1 receptor antagonism in the basolateral amygdala. CONCLUSIONS: These data identify neuronal circuits and cell populations of the amygdala associated with the facilitation of fear extinction consolidation induced by the orexin-1 receptor antagonist SB334867.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34051
http://dx.doi.org/10.1093/ijnp/pyx029
url http://hdl.handle.net/10230/34051
http://dx.doi.org/10.1093/ijnp/pyx029
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Neuropsychopharmacology. 2017 Aug 1;20(8):654-9
info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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