The systemic inflammome of severe obesity before and after bariatric surgery

INTRODUCTION: Obesity is associated with low-grade systemic inflammation. The 'inflammome' is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidi...

Descripción completa

Detalles Bibliográficos
Autores: Arismendi, Ebymar, Riva, Eva, Agustí García-Navarro, Àlvar, Ríos, José, Barreiro, Esther, Vidal i Cortada, Josep, Rodríguez-Roisin, Robert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/111387
Acceso en línea:https://hdl.handle.net/2445/111387
Access Level:acceso abierto
Palabra clave:Obesitat mòrbida
Inflamació
Marcadors bioquímics
Cirurgia de l'obesitat
Morbid obesity
Inflammation
Biochemical markers
Obesity surgery
id ES_8cb1685403549906cbbfeb393da894e4
oai_identifier_str oai:diposit.ub.edu:2445/111387
network_acronym_str ES
network_name_str España
repository_id_str
spelling The systemic inflammome of severe obesity before and after bariatric surgeryArismendi, EbymarRiva, EvaAgustí García-Navarro, ÀlvarRíos, JoséBarreiro, EstherVidal i Cortada, JosepRodríguez-Roisin, RobertObesitat mòrbidaInflamacióMarcadors bioquímicsCirurgia de l'obesitatMorbid obesityInflammationBiochemical markersObesity surgeryINTRODUCTION: Obesity is associated with low-grade systemic inflammation. The 'inflammome' is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery (BS). Besides, whether or not these changes are mirrored in the lungs is unknown, but obesity is often associated with pulmonary inflammation and bronchial hyperresponsiveness. OBJECTIVES: We sought to: (1) describe the systemic inflammome of morbid obesity; (2) investigate the effects of sex, smoking, sleep apnea syndrome, metabolic syndrome and BS upon this systemic inflammome; and, (3) determine their interplay with pulmonary inflammation. METHODS: We studied 129 morbidly obese patients (96 females; age 46 ± 12 years; body mass index [BMI], 46 ± 6 kg/m2) before and one year after BS, and 20 healthy, never-smokers, (43 ± 7 years), with normal BMI and spirometry. RESULTS: Before BS, compared with controls, all obese subjects displayed a strong and coordinated (inflammome) systemic inflammatory response (adiponectin, C-reactive protein, interleukin (IL)-8, IL-10, leptin, soluble tumor necrosis factor-receptor 1(sTNF-R1), and 8-isoprostane). This inflammome was not modified by sex, smoking, or coexistence of obstructive sleep apnea and/or metabolic syndrome. By contrast, it was significantly ameliorated, albeit not completely abolished, after BS. Finally, obese subjects had evidence of pulmonary inflammation (exhaled condensate) that also decreased after BS. CONCLUSIONS: The systemic inflammome of morbid obesity is independent of sex, smoking status and/or comorbidities, it is significantly reduced by BS and mirrored in the lungs.Public Library of Science (PLoS)2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/111387Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0107859PLoS One, 2014, vol. 9, num. 9, p. e107859https://doi.org/10.1371/journal.pone.0107859cc-by (c) Arismendi, Ebymar et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1113872026-05-27T06:46:51Z
dc.title.none.fl_str_mv The systemic inflammome of severe obesity before and after bariatric surgery
title The systemic inflammome of severe obesity before and after bariatric surgery
spellingShingle The systemic inflammome of severe obesity before and after bariatric surgery
Arismendi, Ebymar
Obesitat mòrbida
Inflamació
Marcadors bioquímics
Cirurgia de l'obesitat
Morbid obesity
Inflammation
Biochemical markers
Obesity surgery
title_short The systemic inflammome of severe obesity before and after bariatric surgery
title_full The systemic inflammome of severe obesity before and after bariatric surgery
title_fullStr The systemic inflammome of severe obesity before and after bariatric surgery
title_full_unstemmed The systemic inflammome of severe obesity before and after bariatric surgery
title_sort The systemic inflammome of severe obesity before and after bariatric surgery
dc.creator.none.fl_str_mv Arismendi, Ebymar
Riva, Eva
Agustí García-Navarro, Àlvar
Ríos, José
Barreiro, Esther
Vidal i Cortada, Josep
Rodríguez-Roisin, Robert
author Arismendi, Ebymar
author_facet Arismendi, Ebymar
Riva, Eva
Agustí García-Navarro, Àlvar
Ríos, José
Barreiro, Esther
Vidal i Cortada, Josep
Rodríguez-Roisin, Robert
author_role author
author2 Riva, Eva
Agustí García-Navarro, Àlvar
Ríos, José
Barreiro, Esther
Vidal i Cortada, Josep
Rodríguez-Roisin, Robert
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat mòrbida
Inflamació
Marcadors bioquímics
Cirurgia de l'obesitat
Morbid obesity
Inflammation
Biochemical markers
Obesity surgery
topic Obesitat mòrbida
Inflamació
Marcadors bioquímics
Cirurgia de l'obesitat
Morbid obesity
Inflammation
Biochemical markers
Obesity surgery
description INTRODUCTION: Obesity is associated with low-grade systemic inflammation. The 'inflammome' is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery (BS). Besides, whether or not these changes are mirrored in the lungs is unknown, but obesity is often associated with pulmonary inflammation and bronchial hyperresponsiveness. OBJECTIVES: We sought to: (1) describe the systemic inflammome of morbid obesity; (2) investigate the effects of sex, smoking, sleep apnea syndrome, metabolic syndrome and BS upon this systemic inflammome; and, (3) determine their interplay with pulmonary inflammation. METHODS: We studied 129 morbidly obese patients (96 females; age 46 ± 12 years; body mass index [BMI], 46 ± 6 kg/m2) before and one year after BS, and 20 healthy, never-smokers, (43 ± 7 years), with normal BMI and spirometry. RESULTS: Before BS, compared with controls, all obese subjects displayed a strong and coordinated (inflammome) systemic inflammatory response (adiponectin, C-reactive protein, interleukin (IL)-8, IL-10, leptin, soluble tumor necrosis factor-receptor 1(sTNF-R1), and 8-isoprostane). This inflammome was not modified by sex, smoking, or coexistence of obstructive sleep apnea and/or metabolic syndrome. By contrast, it was significantly ameliorated, albeit not completely abolished, after BS. Finally, obese subjects had evidence of pulmonary inflammation (exhaled condensate) that also decreased after BS. CONCLUSIONS: The systemic inflammome of morbid obesity is independent of sex, smoking status and/or comorbidities, it is significantly reduced by BS and mirrored in the lungs.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/111387
url https://hdl.handle.net/2445/111387
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0107859
PLoS One, 2014, vol. 9, num. 9, p. e107859
https://doi.org/10.1371/journal.pone.0107859
dc.rights.none.fl_str_mv cc-by (c) Arismendi, Ebymar et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Arismendi, Ebymar et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412953383501824
score 15.300724

Similares en LA Referencia