Lithium levels and lifestyle in patients with bipolar disorder: a new tool for self-management

BACKGROUND: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder. METHODS: A multicenter study was performed....

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Detalles Bibliográficos
Autores: Zorrilla Martínez, Iñaki, López Zurbano, Saioa, Alberich, Susana, Barbero Martínez, Ismael, López Peña, María Purificación, García Corres, E., Chart Pascual, Juan Pablo, Crespo, José Manuel, De Dios, C., Balanzá Martínez, Vicent, González Pinto Arrillaga, Ana María
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/60517
Acceso en línea:http://hdl.handle.net/10810/60517
Access Level:acceso abierto
Palabra clave:bipolar disorder
healthy diet
lifestyle factors
lithium
sleep
wearable
Descripción
Sumario:BACKGROUND: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder. METHODS: A multicenter study was performed. In total, 157 lithium measurements were done biweekly in a sample of 65 patients (35 women) over 6weeks. Lifestyle, based on total sleep hours and physical activity, was assessed by actigraphy. Diet was evaluated using the Mediterranean Lifestyle Index (Medlife). RESULTS: 35.4% of patients had a normal weight. The mean Medlife score was 14.5 (±2.5) (moderate-good adherence to Mediterranean diet). BMI, daily dose of lithium and intensity of physical activity had a combined effect on lithium levels, after adjustment for other variables. Patients who practiced intense physical exercise, who took lower doses and had a higher BMI exhibited lower levels of lithium. CONCLUSIONS: Higher physical activity and BMI contribute to lower lithium levels. Patients should be made aware of these relationships to improve their perception of control and self-management. Lifestyle-based interventions contribute to establishing a more personalized medicine.

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