Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb

Introduction: neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case report: we report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-...

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Autores: Valle Del Barrio, Beatriz, Maya-Enero, Silvia, Rodríguez-Sevilla, Juan José, Canals Surís, Carme, Bosch Llobet, Alba, López-Vílchez, María Ángeles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53724
Acceso en línea:http://hdl.handle.net/10230/53724
http://dx.doi.org/10.1159/000514488
Access Level:acceso abierto
Palabra clave:Anti-neutrophil antibodies
Fcγ receptor IIIb
Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
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spelling Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIbValle Del Barrio, BeatrizMaya-Enero, SilviaRodríguez-Sevilla, Juan JoséCanals Surís, CarmeBosch Llobet, AlbaLópez-Vílchez, María ÁngelesAnti-neutrophil antibodiesFcγ receptor IIIbNeonatal alloimmune neutropeniaNeonatal isoimmune neutropeniaIntroduction: neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case report: we report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an FcγRIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.Karger (S. Karger AG)202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53724http://dx.doi.org/10.1159/000514488reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThis article is licensed under the Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License (CC BYNC-ND) (http://www.karger.com/Services/OpenAccessLicense). http://creativecommons.org/licenses/by-nc/4.0/. Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/537242026-05-29T05:05:01Z
dc.title.none.fl_str_mv Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
title Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
spellingShingle Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
Valle Del Barrio, Beatriz
Anti-neutrophil antibodies
Fcγ receptor IIIb
Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
title_short Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
title_full Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
title_fullStr Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
title_full_unstemmed Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
title_sort Neonatal immune neutropenia due to isoantibodies against the granulocyte receptor FcγRIIIb
dc.creator.none.fl_str_mv Valle Del Barrio, Beatriz
Maya-Enero, Silvia
Rodríguez-Sevilla, Juan José
Canals Surís, Carme
Bosch Llobet, Alba
López-Vílchez, María Ángeles
author Valle Del Barrio, Beatriz
author_facet Valle Del Barrio, Beatriz
Maya-Enero, Silvia
Rodríguez-Sevilla, Juan José
Canals Surís, Carme
Bosch Llobet, Alba
López-Vílchez, María Ángeles
author_role author
author2 Maya-Enero, Silvia
Rodríguez-Sevilla, Juan José
Canals Surís, Carme
Bosch Llobet, Alba
López-Vílchez, María Ángeles
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Anti-neutrophil antibodies
Fcγ receptor IIIb
Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
topic Anti-neutrophil antibodies
Fcγ receptor IIIb
Neonatal alloimmune neutropenia
Neonatal isoimmune neutropenia
description Introduction: neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case report: we report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an FcγRIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53724
http://dx.doi.org/10.1159/000514488
url http://hdl.handle.net/10230/53724
http://dx.doi.org/10.1159/000514488
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger (S. Karger AG)
publisher.none.fl_str_mv Karger (S. Karger AG)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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