Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications

[The bigger picture] In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabil...

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Autores: Miralles-Comins, Sara, Zanatta, Marcileia, García Embid, Sonia, Alleva, María, Chiappone, Annalisa, Roppolo, Ignazio, Mitchell, Scott G., Sans, Victor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/354438
Acceso en línea:http://hdl.handle.net/10261/354438
Access Level:acceso abierto
Palabra clave:3D printing
Biocompatible
Polymerizable ionic liquids
Additive manufacturing
Antimicrobials
Digital light processing
Stereolithography
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oai_identifier_str oai:digital.csic.es:10261/354438
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
title Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
spellingShingle Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
Miralles-Comins, Sara
3D printing
Biocompatible
Polymerizable ionic liquids
Additive manufacturing
Antimicrobials
Digital light processing
Stereolithography
title_short Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
title_full Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
title_fullStr Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
title_full_unstemmed Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
title_sort Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
dc.creator.none.fl_str_mv Miralles-Comins, Sara
Zanatta, Marcileia
García Embid, Sonia
Alleva, María
Chiappone, Annalisa
Roppolo, Ignazio
Mitchell, Scott G.
Sans, Victor
author Miralles-Comins, Sara
author_facet Miralles-Comins, Sara
Zanatta, Marcileia
García Embid, Sonia
Alleva, María
Chiappone, Annalisa
Roppolo, Ignazio
Mitchell, Scott G.
Sans, Victor
author_role author
author2 Zanatta, Marcileia
García Embid, Sonia
Alleva, María
Chiappone, Annalisa
Roppolo, Ignazio
Mitchell, Scott G.
Sans, Victor
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Generalitat Valenciana
European Commission
Universidad Jaime I
Gobierno de Aragón
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 3D printing
Biocompatible
Polymerizable ionic liquids
Additive manufacturing
Antimicrobials
Digital light processing
Stereolithography
topic 3D printing
Biocompatible
Polymerizable ionic liquids
Additive manufacturing
Antimicrobials
Digital light processing
Stereolithography
description [The bigger picture] In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabilization challenges, while being optimized for 3D printing. Customized formulations for digital light processing and masked stereolithography-based 3D printing are introduced, resulting in high-resolution materials with potent antimicrobial properties. Successful 3D printing of a device analogous to a medical stent demonstrated their efficacy against the growth of S. epidermidis bacteria. This research underscores additive manufacturing’s transformative potential for high-resolution devices, contributing significantly to a critical global health concern. It establishes a foundation for diverse antimicrobial solutions, marking a substantial advancement in the field.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/354438
url http://hdl.handle.net/10261/354438
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141276OB-I00
info:eu-repo/grantAgreement/EC/H2020/101026335
Miralles-Comins, Sara; Zanatta, Marcileia; García Embid, Sonia; Alleva, María; Chiappone, Annalisa; Roppolo, Ignazio; Mitchell, Scott G.; Sans, Victor; 2024; Supplemental information for Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications [Dataset]; Elsevier; https://doi.org/10.1016/j.device.2023.100224
https://doi.org/10.1016/j.device.2023.100224
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applicationsMiralles-Comins, SaraZanatta, MarcileiaGarcía Embid, SoniaAlleva, MaríaChiappone, AnnalisaRoppolo, IgnazioMitchell, Scott G.Sans, Victor3D printingBiocompatiblePolymerizable ionic liquidsAdditive manufacturingAntimicrobialsDigital light processingStereolithography[The bigger picture] In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabilization challenges, while being optimized for 3D printing. Customized formulations for digital light processing and masked stereolithography-based 3D printing are introduced, resulting in high-resolution materials with potent antimicrobial properties. Successful 3D printing of a device analogous to a medical stent demonstrated their efficacy against the growth of S. epidermidis bacteria. This research underscores additive manufacturing’s transformative potential for high-resolution devices, contributing significantly to a critical global health concern. It establishes a foundation for diverse antimicrobial solutions, marking a substantial advancement in the field.[Summary] In recent years, 3D printing has undergone a significant transformation, expanding beyond its initial niche applications, such as rapid prototyping and hobbyist projects. This evolution has been characterized by advancements in equipment, software, and, most notably, materials. However, the development of materials that present high-resolution and advanced tunable functionalities is still a challenge. Herein, we report the development of modular 3D-printable antimicrobial polymeric ionic liquid (PIL) scaffolds with in situ formation of copper-based nanoparticles within the polymeric matrix (Cu@PILs). A variety of formulations were specially designed and optimized to be printed by digital light processing and masked stereolithography techniques at high resolution. The antimicrobial activity as well as the biocompatibility of the different formulations was tested, changing the monomeric ionic liquid and the photoinitiator. Tailor-made objects were successfully manufactured, and as a demonstrator, a geometry compatible with a medical stent was printed.This project was funded through the Generalitat Valenciana (CIDEGENT 2018/036 and ACIF/2020/338) and Fondo Social Europeo. Universitat Jaume I is gratefully acknowledged for funding (UJI B-2020-44). This study was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) promoted by the Government of Aragon. This work was funded through the grant PID2022-141276OB-I00 funded by MCIN/AEI/10.13039/501100011033 (Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación, Spain). This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No (GA no. 101026335).Peer reviewedElsevierGeneralitat ValencianaEuropean CommissionUniversidad Jaime IGobierno de AragónMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/354438reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141276OB-I00info:eu-repo/grantAgreement/EC/H2020/101026335Miralles-Comins, Sara; Zanatta, Marcileia; García Embid, Sonia; Alleva, María; Chiappone, Annalisa; Roppolo, Ignazio; Mitchell, Scott G.; Sans, Victor; 2024; Supplemental information for Development of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications [Dataset]; Elsevier; https://doi.org/10.1016/j.device.2023.100224https://doi.org/10.1016/j.device.2023.100224Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3544382026-05-22T06:33:51Z
score 15,81155

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