State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease

Hampel, Harald; Shaw, Leslie M.; Aisen, Paul; Chen, Christopher; Lleó, Alberto|||0000-0002-2568-5478; Iwatsubo, Takeshi; Iwata, Atsushi; Yamada, Masahito; Ikeuchi, Takeshi|||0000-0001-8828-8085; Jia, Jianping; Wang, Huali; Teunissen, Charlotte E.|||0000-0002-4061-0837; Peskind, Elaine; Blennow, Kaj|||0000-0002-1890-4193; Cummings, Jeffrey; Vergallo, Andrea

State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease

Recent advances in developing disease-modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health-care systems toward biomarker-guided early detection, diagnosis, and therape...

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Autores:	Hampel, Harald, Shaw, Leslie M., Aisen, Paul, Chen, Christopher, Lleó, Alberto\|\|\|0000-0002-2568-5478, Iwatsubo, Takeshi, Iwata, Atsushi, Yamada, Masahito, Ikeuchi, Takeshi\|\|\|0000-0001-8828-8085, Jia, Jianping, Wang, Huali, Teunissen, Charlotte E.\|\|\|0000-0002-4061-0837, Peskind, Elaine, Blennow, Kaj\|\|\|0000-0002-1890-4193, Cummings, Jeffrey, Vergallo, Andrea
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:282283
Acceso en línea:	https://ddd.uab.cat/record/282283 https://dx.doi.org/urn:doi:10.1002/alz.12372
Access Level:	acceso abierto
Palabra clave:	Alzheimer's disease Biomarker Cerebrospinal fluid Diagnosis Evidence-based guidelines Lumbar puncture System readiness

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spelling	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's diseaseHampel, HaraldShaw, Leslie M.Aisen, PaulChen, ChristopherLleó, Alberto\|\|\|0000-0002-2568-5478Iwatsubo, TakeshiIwata, AtsushiYamada, MasahitoIkeuchi, Takeshi\|\|\|0000-0001-8828-8085Jia, JianpingWang, HualiTeunissen, Charlotte E.\|\|\|0000-0002-4061-0837Peskind, ElaineBlennow, Kaj\|\|\|0000-0002-1890-4193Cummings, JeffreyVergallo, AndreaAlzheimer's diseaseBiomarkerCerebrospinal fluidDiagnosisEvidence-based guidelinesLumbar punctureSystem readinessRecent advances in developing disease-modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health-care systems toward biomarker-guided early detection, diagnosis, and therapeutic decision-making. Appropriate incorporation of cerebrospinal fluid biomarker analysis in clinical practice is an essential step toward system readiness for accommodating the demand of AD diagnosis and proper use of DMTs-once they become available. However, the use of lumbar puncture (LP) in individuals with suspected neurodegenerative diseases such as AD is inconsistent, and the perception of its utility and safety differs considerably among medical specialties as well as among regions and countries. This review describes the state-of-the-art evidence concerning the safety profile of LP in older adults, discusses the risk factors for LP-associated adverse events, and provides recommendations and an outlook for optimized use and global implementation of LP in individuals with suspected AD.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282283https://dx.doi.org/urn:doi:10.1002/alz.12372reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2822832026-06-06T12:50:31Z
dc.title.none.fl_str_mv	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
title	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
spellingShingle	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease Hampel, Harald Alzheimer's disease Biomarker Cerebrospinal fluid Diagnosis Evidence-based guidelines Lumbar puncture System readiness
title_short	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
title_full	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
title_fullStr	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
title_full_unstemmed	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
title_sort	State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease
dc.creator.none.fl_str_mv	Hampel, Harald Shaw, Leslie M. Aisen, Paul Chen, Christopher Lleó, Alberto\|\|\|0000-0002-2568-5478 Iwatsubo, Takeshi Iwata, Atsushi Yamada, Masahito Ikeuchi, Takeshi\|\|\|0000-0001-8828-8085 Jia, Jianping Wang, Huali Teunissen, Charlotte E.\|\|\|0000-0002-4061-0837 Peskind, Elaine Blennow, Kaj\|\|\|0000-0002-1890-4193 Cummings, Jeffrey Vergallo, Andrea
author	Hampel, Harald
author_facet	Hampel, Harald Shaw, Leslie M. Aisen, Paul Chen, Christopher Lleó, Alberto\|\|\|0000-0002-2568-5478 Iwatsubo, Takeshi Iwata, Atsushi Yamada, Masahito Ikeuchi, Takeshi\|\|\|0000-0001-8828-8085 Jia, Jianping Wang, Huali Teunissen, Charlotte E.\|\|\|0000-0002-4061-0837 Peskind, Elaine Blennow, Kaj\|\|\|0000-0002-1890-4193 Cummings, Jeffrey Vergallo, Andrea
author_role	author
author2	Shaw, Leslie M. Aisen, Paul Chen, Christopher Lleó, Alberto\|\|\|0000-0002-2568-5478 Iwatsubo, Takeshi Iwata, Atsushi Yamada, Masahito Ikeuchi, Takeshi\|\|\|0000-0001-8828-8085 Jia, Jianping Wang, Huali Teunissen, Charlotte E.\|\|\|0000-0002-4061-0837 Peskind, Elaine Blennow, Kaj\|\|\|0000-0002-1890-4193 Cummings, Jeffrey Vergallo, Andrea
author2_role	author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Alzheimer's disease Biomarker Cerebrospinal fluid Diagnosis Evidence-based guidelines Lumbar puncture System readiness
topic	Alzheimer's disease Biomarker Cerebrospinal fluid Diagnosis Evidence-based guidelines Lumbar puncture System readiness
description	Recent advances in developing disease-modifying therapies (DMT) for Alzheimer's disease (AD), and the recognition that AD pathophysiology emerges decades before clinical symptoms, necessitate a paradigm shift of health-care systems toward biomarker-guided early detection, diagnosis, and therapeutic decision-making. Appropriate incorporation of cerebrospinal fluid biomarker analysis in clinical practice is an essential step toward system readiness for accommodating the demand of AD diagnosis and proper use of DMTs-once they become available. However, the use of lumbar puncture (LP) in individuals with suspected neurodegenerative diseases such as AD is inconsistent, and the perception of its utility and safety differs considerably among medical specialties as well as among regions and countries. This review describes the state-of-the-art evidence concerning the safety profile of LP in older adults, discusses the risk factors for LP-associated adverse events, and provides recommendations and an outlook for optimized use and global implementation of LP in individuals with suspected AD.
publishDate	2022
dc.date.none.fl_str_mv	2 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	Article de revisió http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/282283 https://dx.doi.org/urn:doi:10.1002/alz.12372
url	https://ddd.uab.cat/record/282283 https://dx.doi.org/urn:doi:10.1002/alz.12372
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease

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