The challenge of aging and pharmacoterapeutic complexity in the HIV + patient

Objective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharma...

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Autores: Morillo Verdugo, Ramón Alejandro, Ramos Blanco, José Ramón, Abdel-Kader Martín, Laila, Álvarez de Sotomayor Paz, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/95618
Acceso en línea:https://hdl.handle.net/11441/95618
https://doi.org/10.7399/fh.10931
Access Level:acceso abierto
Palabra clave:Aging
HIV
Pharmacoterapeutical complexity
Polypharmacy
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spelling The challenge of aging and pharmacoterapeutic complexity in the HIV + patientEl reto del envejecimiento y la complejidad farmacoterapéutica en el paciente VIH+Morillo Verdugo, Ramón AlejandroRamos Blanco, José RamónAbdel-Kader Martín, LailaÁlvarez de Sotomayor Paz, MaríaAgingHIVPharmacoterapeutical complexityPolypharmacyObjective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms «Polypharmacy»/«Polifarmacia», «Aging»/«Envejecimiento», «Frailty»/«Fragilidad», «Complejidad Farmacotera péutica»/«Medication Regimen Complexity» and «HIV»/«VIH» were combined. The review was carried out independently by two authors. The degree of agreement, according to the Kappa index, was analysed. Results: A total of 208 references were analysed, including, finally, only 68. An aging of the population and an increase in associated comorbidities have been identified, especially over 50 years-old. Immunological changes similar to those that are generated in a non-infected elderly population have been described. These conditions influencing the prescription of antiretroviral treatment, according to studies identified. In parallel, polypharmacy is increasingly present, being defined exclusively by the concomitant use of five drugs. Pharmacotherapeutic complexity, through the Medication Regimen Complexity Index, has begun to analyse and relate to health outcomes. There has been a need to know and apply concepts already known in non-HIV-aged population, such as deprescription, potentially inappropriate medication, cholinergic risk, although few results are available. Conclusions: There is a growing interest to know about the relationship between HIV and aging. Pharmacotherapeutic complexity is beginning to be used as a pharmacotherapeutic follow-up criterion due to its influence on health outcomes. It is necessary to manage and incorporate new concepts that help pharmacotherapeutic optimization in this population.Grupo Aula Medica S.L.Farmacología2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/95618https://doi.org/10.7399/fh.10931reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFarmacia Hospitalaria, 42 (3), 120-127.http://dx.doi.org/10.7399/fh.10931info:eu-repo/semantics/openAccessoai:idus.us.es:11441/956182026-06-17T12:51:07Z
dc.title.none.fl_str_mv The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
El reto del envejecimiento y la complejidad farmacoterapéutica en el paciente VIH+
title The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
spellingShingle The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
Morillo Verdugo, Ramón Alejandro
Aging
HIV
Pharmacoterapeutical complexity
Polypharmacy
title_short The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
title_full The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
title_fullStr The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
title_full_unstemmed The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
title_sort The challenge of aging and pharmacoterapeutic complexity in the HIV + patient
dc.creator.none.fl_str_mv Morillo Verdugo, Ramón Alejandro
Ramos Blanco, José Ramón
Abdel-Kader Martín, Laila
Álvarez de Sotomayor Paz, María
author Morillo Verdugo, Ramón Alejandro
author_facet Morillo Verdugo, Ramón Alejandro
Ramos Blanco, José Ramón
Abdel-Kader Martín, Laila
Álvarez de Sotomayor Paz, María
author_role author
author2 Ramos Blanco, José Ramón
Abdel-Kader Martín, Laila
Álvarez de Sotomayor Paz, María
author2_role author
author
author
dc.contributor.none.fl_str_mv Farmacología
dc.subject.none.fl_str_mv Aging
HIV
Pharmacoterapeutical complexity
Polypharmacy
topic Aging
HIV
Pharmacoterapeutical complexity
Polypharmacy
description Objective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms «Polypharmacy»/«Polifarmacia», «Aging»/«Envejecimiento», «Frailty»/«Fragilidad», «Complejidad Farmacotera péutica»/«Medication Regimen Complexity» and «HIV»/«VIH» were combined. The review was carried out independently by two authors. The degree of agreement, according to the Kappa index, was analysed. Results: A total of 208 references were analysed, including, finally, only 68. An aging of the population and an increase in associated comorbidities have been identified, especially over 50 years-old. Immunological changes similar to those that are generated in a non-infected elderly population have been described. These conditions influencing the prescription of antiretroviral treatment, according to studies identified. In parallel, polypharmacy is increasingly present, being defined exclusively by the concomitant use of five drugs. Pharmacotherapeutic complexity, through the Medication Regimen Complexity Index, has begun to analyse and relate to health outcomes. There has been a need to know and apply concepts already known in non-HIV-aged population, such as deprescription, potentially inappropriate medication, cholinergic risk, although few results are available. Conclusions: There is a growing interest to know about the relationship between HIV and aging. Pharmacotherapeutic complexity is beginning to be used as a pharmacotherapeutic follow-up criterion due to its influence on health outcomes. It is necessary to manage and incorporate new concepts that help pharmacotherapeutic optimization in this population.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/95618
https://doi.org/10.7399/fh.10931
url https://hdl.handle.net/11441/95618
https://doi.org/10.7399/fh.10931
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Farmacia Hospitalaria, 42 (3), 120-127.
http://dx.doi.org/10.7399/fh.10931
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Grupo Aula Medica S.L.
publisher.none.fl_str_mv Grupo Aula Medica S.L.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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