Differential progression of regional hippocampal atrophy in aging and Parkinson's disease

Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regi...

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Detalhes bibliográficos
Autores: Uribe, Carme, Segura i Fàbregas, Bàrbara, Baggio, Hugo César, Campabadal Delgado, Anna, Abós, Alexandra, Compta, Yaroslau, Martí Domènech, Ma. Josep, Valldeoriola Serra, Francesc, Bargalló Alabart, Núria, Junqué i Plaja, Carme, 1955-
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/140428
Acesso em linha:https://hdl.handle.net/2445/140428
Access Level:acceso abierto
Palavra-chave:Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
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spelling Differential progression of regional hippocampal atrophy in aging and Parkinson's diseaseUribe, CarmeSegura i Fàbregas, BàrbaraBaggio, Hugo CésarCampabadal Delgado, AnnaAbós, AlexandraCompta, YaroslauMartí Domènech, Ma. JosepValldeoriola Serra, FrancescBargalló Alabart, NúriaJunqué i Plaja, Carme, 1955-Malaltia de ParkinsonEnvellimentNeurologiaParkinson's diseaseAgingNeurologyHippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regional hippocampal changes over time in a sample of PD patients classified according to their baseline cognitive status and to relate these changes to verbal memory loss. T1-weighted images and verbal memory assessment were obtained at two separate time points (3.8 ± 0.4 years apart) from 28 PD with normal cognition (PD-NC), 16 PD with MCI (PD-MCI) and 21 healthy controls (HCs). FreeSurfer 6.0 automated pipeline was used to segment the hippocampus into 12 bilateral subregions. Memory functions were measured with Rey's Auditory Verbal learning test (RAVLT). We found significant reductions in cornu ammonis 1 (CA1) over time in controls as well as in PD subgroups. Right whole-hippocampal volumes showed time effects in both PD groups but not in controls. PD-NC patients also displayed time effects in the left hippocampal tail and right parasubiculum. Regression analyses showed that specific hippocampal subfield volumes at time 1 predicted almost 60% of the variability in RAVLT delayed-recall score decline. Changes in several hippocampal subregions also showed predictive value for memory loss. In conclusion, CA1 changes in PD were similar to those that occur in normal aging, but PD patients also had more decline in both anterior and posterior hippocampal segments with a more pronounced atrophy of the right hemisphere. Hippocampal segments are better predictors of changes in memory performance than whole-hippocampal volumes.Frontiers Media2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/140428Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00325Frontiers in Aging Neuroscience, 2018, vol. 10, p. 325https://doi.org/10.3389/fnagi.2018.00325cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1404282026-05-27T06:46:51Z
dc.title.none.fl_str_mv Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
spellingShingle Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
Uribe, Carme
Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
title_short Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_full Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_fullStr Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_full_unstemmed Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
title_sort Differential progression of regional hippocampal atrophy in aging and Parkinson's disease
dc.creator.none.fl_str_mv Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author Uribe, Carme
author_facet Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Campabadal Delgado, Anna
Abós, Alexandra
Compta, Yaroslau
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
topic Malaltia de Parkinson
Envelliment
Neurologia
Parkinson's disease
Aging
Neurology
description Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the temporal evolution in Parkinson's disease (PD) is unknown. The purposes of the current work are to describe regional hippocampal changes over time in a sample of PD patients classified according to their baseline cognitive status and to relate these changes to verbal memory loss. T1-weighted images and verbal memory assessment were obtained at two separate time points (3.8 ± 0.4 years apart) from 28 PD with normal cognition (PD-NC), 16 PD with MCI (PD-MCI) and 21 healthy controls (HCs). FreeSurfer 6.0 automated pipeline was used to segment the hippocampus into 12 bilateral subregions. Memory functions were measured with Rey's Auditory Verbal learning test (RAVLT). We found significant reductions in cornu ammonis 1 (CA1) over time in controls as well as in PD subgroups. Right whole-hippocampal volumes showed time effects in both PD groups but not in controls. PD-NC patients also displayed time effects in the left hippocampal tail and right parasubiculum. Regression analyses showed that specific hippocampal subfield volumes at time 1 predicted almost 60% of the variability in RAVLT delayed-recall score decline. Changes in several hippocampal subregions also showed predictive value for memory loss. In conclusion, CA1 changes in PD were similar to those that occur in normal aging, but PD patients also had more decline in both anterior and posterior hippocampal segments with a more pronounced atrophy of the right hemisphere. Hippocampal segments are better predictors of changes in memory performance than whole-hippocampal volumes.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140428
url https://hdl.handle.net/2445/140428
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00325
Frontiers in Aging Neuroscience, 2018, vol. 10, p. 325
https://doi.org/10.3389/fnagi.2018.00325
dc.rights.none.fl_str_mv cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Uribe Codesal, Ma. Del Carmen et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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