Prognostic value of IL-6 in the localized prostatic cancer

AIM: The usefulness of interleukin 6 (IL-6) and its soluble receptor IL-6sR in the prediction of the biochemical recurrence was evaluated in patients with prostate cancer treated with radical prostatectomy. PATIENTS AND METHODS: IL-6 and sIL-6R serum levels were measured in 96 patients with prostate...

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Autores: Alcover García, Juan, Filella Pla, Xavier, Luque Gálvez, Ma. Pilar, Molina, Rafael (Molina Porto), Izquierdo Reyes, Laura, Augé Fradera, Josep Maria, Alcaraz Asensio, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/132010
Acceso en línea:https://hdl.handle.net/2445/132010
Access Level:acceso abierto
Palabra clave:Càncer de pròstata
Tumors
Marcadors tumorals
Prostate cancer
Tumor markers
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repository_id_str
spelling Prognostic value of IL-6 in the localized prostatic cancerAlcover García, JuanFilella Pla, XavierLuque Gálvez, Ma. PilarMolina, Rafael (Molina Porto)Izquierdo Reyes, LauraAugé Fradera, Josep MariaAlcaraz Asensio, AntonioCàncer de pròstataTumorsMarcadors tumoralsProstate cancerTumorsTumor markersAIM: The usefulness of interleukin 6 (IL-6) and its soluble receptor IL-6sR in the prediction of the biochemical recurrence was evaluated in patients with prostate cancer treated with radical prostatectomy. PATIENTS AND METHODS: IL-6 and sIL-6R serum levels were measured in 96 patients with prostate cancer. RESULTS: Using the log-rank test, it was evident that patients with preoperative serum levels of IL-6 higher than 1.2 pg/ml had a significantly increased probability of biochemical recurrence (p=0.031). We also observed that the Gleason score was associated with the risk of progression (p=0.033), but no relation was observed with TNM classification, PSA, % free PSA or sIL-6R. In a multivariate analysis, only IL-6 serum levels remained as a predictor of biochemical recurrence (p=0.040). CONCLUSION: The results presented here demonstrated the usefulness of IL-6 in predicting the biochemical progression of prostate cancer, pointing towards an association between inflammation and the aggressiveness of the tumor.International Institute of Anticancer Research2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/132010Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://ar.iiarjournals.org/content/30/10/4369.longAnticancer Research, 2010, vol. 30, num. 10, p. 4369-4372(c) International Institute of Anticancer Research, 2010info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1320102026-05-27T06:46:51Z
dc.title.none.fl_str_mv Prognostic value of IL-6 in the localized prostatic cancer
title Prognostic value of IL-6 in the localized prostatic cancer
spellingShingle Prognostic value of IL-6 in the localized prostatic cancer
Alcover García, Juan
Càncer de pròstata
Tumors
Marcadors tumorals
Prostate cancer
Tumors
Tumor markers
title_short Prognostic value of IL-6 in the localized prostatic cancer
title_full Prognostic value of IL-6 in the localized prostatic cancer
title_fullStr Prognostic value of IL-6 in the localized prostatic cancer
title_full_unstemmed Prognostic value of IL-6 in the localized prostatic cancer
title_sort Prognostic value of IL-6 in the localized prostatic cancer
dc.creator.none.fl_str_mv Alcover García, Juan
Filella Pla, Xavier
Luque Gálvez, Ma. Pilar
Molina, Rafael (Molina Porto)
Izquierdo Reyes, Laura
Augé Fradera, Josep Maria
Alcaraz Asensio, Antonio
author Alcover García, Juan
author_facet Alcover García, Juan
Filella Pla, Xavier
Luque Gálvez, Ma. Pilar
Molina, Rafael (Molina Porto)
Izquierdo Reyes, Laura
Augé Fradera, Josep Maria
Alcaraz Asensio, Antonio
author_role author
author2 Filella Pla, Xavier
Luque Gálvez, Ma. Pilar
Molina, Rafael (Molina Porto)
Izquierdo Reyes, Laura
Augé Fradera, Josep Maria
Alcaraz Asensio, Antonio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de pròstata
Tumors
Marcadors tumorals
Prostate cancer
Tumors
Tumor markers
topic Càncer de pròstata
Tumors
Marcadors tumorals
Prostate cancer
Tumors
Tumor markers
description AIM: The usefulness of interleukin 6 (IL-6) and its soluble receptor IL-6sR in the prediction of the biochemical recurrence was evaluated in patients with prostate cancer treated with radical prostatectomy. PATIENTS AND METHODS: IL-6 and sIL-6R serum levels were measured in 96 patients with prostate cancer. RESULTS: Using the log-rank test, it was evident that patients with preoperative serum levels of IL-6 higher than 1.2 pg/ml had a significantly increased probability of biochemical recurrence (p=0.031). We also observed that the Gleason score was associated with the risk of progression (p=0.033), but no relation was observed with TNM classification, PSA, % free PSA or sIL-6R. In a multivariate analysis, only IL-6 serum levels remained as a predictor of biochemical recurrence (p=0.040). CONCLUSION: The results presented here demonstrated the usefulness of IL-6 in predicting the biochemical progression of prostate cancer, pointing towards an association between inflammation and the aggressiveness of the tumor.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/132010
url https://hdl.handle.net/2445/132010
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://ar.iiarjournals.org/content/30/10/4369.long
Anticancer Research, 2010, vol. 30, num. 10, p. 4369-4372
dc.rights.none.fl_str_mv (c) International Institute of Anticancer Research, 2010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) International Institute of Anticancer Research, 2010
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Institute of Anticancer Research
publisher.none.fl_str_mv International Institute of Anticancer Research
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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