Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis

Background and ObjectivesRecovery of vision after acute optic neuritis (AON) is critical to improving the quality of life of people with demyelinating diseases. The objective of the study was to prospectively assess the changes in visual acuity, retinal layer thickness, and cortical visual network i...

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Autores: Villoslada, Pablo, Solana, Elisabeth, Alba-Arbalat, Salut, Martínez-Heras, Eloy, Vivó Pascual, Francesc, López-Soley, Elisabet, Calvi, Alberto, Camos-Carreras, Anna, Dotti-Boada, Marina, Alcubierre Bailac, Rafel, Martinez-Lapiscina, Elena H., Blanco Morgado, Yolanda, Llufriu, Sara, Sánchez Dalmau, Bernardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/72531
Acceso en línea:https://hdl.handle.net/10230/72531
http://dx.doi.org/10.1212/NXI.0000000000200288
http://hdl.handle.net/10230/72531
Access Level:acceso abierto
Palabra clave:Neuritis
Agudesa visual
Persones amb discapacitat visual
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spelling Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritisVilloslada, PabloSolana, ElisabethAlba-Arbalat, SalutMartínez-Heras, EloyVivó Pascual, FrancescLópez-Soley, ElisabetCalvi, AlbertoCamos-Carreras, AnnaDotti-Boada, MarinaAlcubierre Bailac, RafelMartinez-Lapiscina, Elena H.Blanco Morgado, YolandaLlufriu, SaraSánchez Dalmau, BernardoNeuritisAgudesa visualPersones amb discapacitat visualBackground and ObjectivesRecovery of vision after acute optic neuritis (AON) is critical to improving the quality of life of people with demyelinating diseases. The objective of the study was to prospectively assess the changes in visual acuity, retinal layer thickness, and cortical visual network in patients with AON to identify the predictors of permanent visual disability.MethodsWe studied a prospective cohort of 88 consecutive patients with AON with 6-month follow-up using high and low-contrast (2.5%) visual acuity, color vision, retinal thickness from optical coherence tomography, latencies and amplitudes of multifocal visual evoked potentials, mean deviation of visual fields, and diffusion-based structural (n = 53) and functional (n = 19) brain MRI to analyze the cortical visual network. The primary outcome was 2.5% low-contrast vision, and data were analyzed with mixed-effects and multivariate regression models.ResultsWe found that after 6 months, low-contrast vision and quality of vision remained moderately impaired. The thickness of the ganglion cell layer at baseline was a predictor of low-contrast vision 6 months later (ß = 0.49 [CI 0.11-0.88], p = 0.012). The structural cortical visual network at baseline predicted low-contrast vision, the best predictors being the betweenness of the right parahippocampal cortex (ß = -036 [CI -0.66 to 0.06], p = 0.021), the node strength of the right V3 (ß = 1.72 [CI 0.29-3.15], p = 0.02), and the clustering coefficient of the left intraparietal sulcus (ß = 57.8 [CI 12.3-103.4], p = 0.015). The functional cortical visual network at baseline also predicted low-contrast vision, the best predictors being the betweenness of the left ventral occipital cortex (ß = 8.6 [CI: 4.03-13.3], p = 0.009), the node strength of the right intraparietal sulcus (ß = -2.79 [CI: -5.1-0.4], p = 0.03), and the clustering coefficient of the left superior parietal lobule (ß = 501.5 [CI 50.8-952.2], p = 0.03).DiscussionThe assessment of the visual pathway at baseline predicts permanent vision disability after AON, indicating that damage is produced early after disease onset and that it can be used for defining vision impairment and guiding therapy.Wolters Kluwer (LWW)2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72531http://dx.doi.org/10.1212/NXI.0000000000200288http://hdl.handle.net/10230/72531reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNeurology: Neuroimmunology and NeuroInflammation. 2024;11(6):e200288Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/725312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
title Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
spellingShingle Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
Villoslada, Pablo
Neuritis
Agudesa visual
Persones amb discapacitat visual
title_short Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
title_full Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
title_fullStr Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
title_full_unstemmed Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
title_sort Retinal damage and visual network reconfiguration defines visual function recovery in optic neuritis
dc.creator.none.fl_str_mv Villoslada, Pablo
Solana, Elisabeth
Alba-Arbalat, Salut
Martínez-Heras, Eloy
Vivó Pascual, Francesc
López-Soley, Elisabet
Calvi, Alberto
Camos-Carreras, Anna
Dotti-Boada, Marina
Alcubierre Bailac, Rafel
Martinez-Lapiscina, Elena H.
Blanco Morgado, Yolanda
Llufriu, Sara
Sánchez Dalmau, Bernardo
author Villoslada, Pablo
author_facet Villoslada, Pablo
Solana, Elisabeth
Alba-Arbalat, Salut
Martínez-Heras, Eloy
Vivó Pascual, Francesc
López-Soley, Elisabet
Calvi, Alberto
Camos-Carreras, Anna
Dotti-Boada, Marina
Alcubierre Bailac, Rafel
Martinez-Lapiscina, Elena H.
Blanco Morgado, Yolanda
Llufriu, Sara
Sánchez Dalmau, Bernardo
author_role author
author2 Solana, Elisabeth
Alba-Arbalat, Salut
Martínez-Heras, Eloy
Vivó Pascual, Francesc
López-Soley, Elisabet
Calvi, Alberto
Camos-Carreras, Anna
Dotti-Boada, Marina
Alcubierre Bailac, Rafel
Martinez-Lapiscina, Elena H.
Blanco Morgado, Yolanda
Llufriu, Sara
Sánchez Dalmau, Bernardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuritis
Agudesa visual
Persones amb discapacitat visual
topic Neuritis
Agudesa visual
Persones amb discapacitat visual
description Background and ObjectivesRecovery of vision after acute optic neuritis (AON) is critical to improving the quality of life of people with demyelinating diseases. The objective of the study was to prospectively assess the changes in visual acuity, retinal layer thickness, and cortical visual network in patients with AON to identify the predictors of permanent visual disability.MethodsWe studied a prospective cohort of 88 consecutive patients with AON with 6-month follow-up using high and low-contrast (2.5%) visual acuity, color vision, retinal thickness from optical coherence tomography, latencies and amplitudes of multifocal visual evoked potentials, mean deviation of visual fields, and diffusion-based structural (n = 53) and functional (n = 19) brain MRI to analyze the cortical visual network. The primary outcome was 2.5% low-contrast vision, and data were analyzed with mixed-effects and multivariate regression models.ResultsWe found that after 6 months, low-contrast vision and quality of vision remained moderately impaired. The thickness of the ganglion cell layer at baseline was a predictor of low-contrast vision 6 months later (ß = 0.49 [CI 0.11-0.88], p = 0.012). The structural cortical visual network at baseline predicted low-contrast vision, the best predictors being the betweenness of the right parahippocampal cortex (ß = -036 [CI -0.66 to 0.06], p = 0.021), the node strength of the right V3 (ß = 1.72 [CI 0.29-3.15], p = 0.02), and the clustering coefficient of the left intraparietal sulcus (ß = 57.8 [CI 12.3-103.4], p = 0.015). The functional cortical visual network at baseline also predicted low-contrast vision, the best predictors being the betweenness of the left ventral occipital cortex (ß = 8.6 [CI: 4.03-13.3], p = 0.009), the node strength of the right intraparietal sulcus (ß = -2.79 [CI: -5.1-0.4], p = 0.03), and the clustering coefficient of the left superior parietal lobule (ß = 501.5 [CI 50.8-952.2], p = 0.03).DiscussionThe assessment of the visual pathway at baseline predicts permanent vision disability after AON, indicating that damage is produced early after disease onset and that it can be used for defining vision impairment and guiding therapy.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72531
http://dx.doi.org/10.1212/NXI.0000000000200288
http://hdl.handle.net/10230/72531
url https://hdl.handle.net/10230/72531
http://dx.doi.org/10.1212/NXI.0000000000200288
http://hdl.handle.net/10230/72531
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neurology: Neuroimmunology and NeuroInflammation. 2024;11(6):e200288
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer (LWW)
publisher.none.fl_str_mv Wolters Kluwer (LWW)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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