Insights into the skin of caecilian amphibians from gene expression profiles

Background: Gene expression profiles can provide insights into the molecular machinery behind tissue functions and, in turn, can further our understanding of environmental responses, and developmental and evolutionary processes. During vertebrate evolution, the skin has played a crucial role, displa...

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Detalles Bibliográficos
Autores: Torres-Sánchez, María, Wilkinson, Mark, Gower, David J., Creevey, Christopher J., San Mauro, Diego
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7894
Acceso en línea:https://hdl.handle.net/20.500.14352/7894
Access Level:acceso abierto
Palabra clave:597.6
575.8
Bioactive peptides
Claudins
Cornified proteins
Gymnophiona
Keratins
Transcriptomics
Anfibios
Evolución
2401.17 Invertebrados
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oai_identifier_str oai:docta.ucm.es:20.500.14352/7894
network_acronym_str ES
network_name_str España
repository_id_str
spelling Insights into the skin of caecilian amphibians from gene expression profilesTorres-Sánchez, MaríaWilkinson, MarkGower, David J.Creevey, Christopher J.San Mauro, Diego597.6575.8Bioactive peptidesClaudinsCornified proteinsGymnophionaKeratinsTranscriptomicsAnfibiosEvolución2401.17 InvertebradosBackground: Gene expression profiles can provide insights into the molecular machinery behind tissue functions and, in turn, can further our understanding of environmental responses, and developmental and evolutionary processes. During vertebrate evolution, the skin has played a crucial role, displaying a wide diversity of essential functions. To unravel the molecular basis of skin specialisations and adaptations, we compared gene expression in the skin with eight other tissues in a phylogenetically and ecologically diverse species sample of one of the most neglected vertebrate groups, the caecilian amphibians (order Gymnophiona). Results: The skin of the five studied caecilian species showed a distinct gene expression profile reflecting its developmental origin and showing similarities to other epithelial tissues. We identified 59 sequences with conserved enhanced expression in the skin that might be associated with caecilian dermal specialisations. Some of the upregulated genes shared expression patterns with human skin and potentially are involved in skin functions across vertebrates. Variation trends in gene expression were detected between mid and posterior body skin suggesting different functions between body regions. Several candidate biologically active peptides were also annotated. Conclusions: Our study provides the first atlas of differentially expressed sequences in caecilian tissues and a baseline to explore the molecular basis of the skin functions in caecilian amphibians, and more broadly in vertebrates.BMCUniversidad Complutense de Madrid20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7894reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/78942026-06-02T12:44:21Z
dc.title.none.fl_str_mv Insights into the skin of caecilian amphibians from gene expression profiles
title Insights into the skin of caecilian amphibians from gene expression profiles
spellingShingle Insights into the skin of caecilian amphibians from gene expression profiles
Torres-Sánchez, María
597.6
575.8
Bioactive peptides
Claudins
Cornified proteins
Gymnophiona
Keratins
Transcriptomics
Anfibios
Evolución
2401.17 Invertebrados
title_short Insights into the skin of caecilian amphibians from gene expression profiles
title_full Insights into the skin of caecilian amphibians from gene expression profiles
title_fullStr Insights into the skin of caecilian amphibians from gene expression profiles
title_full_unstemmed Insights into the skin of caecilian amphibians from gene expression profiles
title_sort Insights into the skin of caecilian amphibians from gene expression profiles
dc.creator.none.fl_str_mv Torres-Sánchez, María
Wilkinson, Mark
Gower, David J.
Creevey, Christopher J.
San Mauro, Diego
author Torres-Sánchez, María
author_facet Torres-Sánchez, María
Wilkinson, Mark
Gower, David J.
Creevey, Christopher J.
San Mauro, Diego
author_role author
author2 Wilkinson, Mark
Gower, David J.
Creevey, Christopher J.
San Mauro, Diego
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 597.6
575.8
Bioactive peptides
Claudins
Cornified proteins
Gymnophiona
Keratins
Transcriptomics
Anfibios
Evolución
2401.17 Invertebrados
topic 597.6
575.8
Bioactive peptides
Claudins
Cornified proteins
Gymnophiona
Keratins
Transcriptomics
Anfibios
Evolución
2401.17 Invertebrados
description Background: Gene expression profiles can provide insights into the molecular machinery behind tissue functions and, in turn, can further our understanding of environmental responses, and developmental and evolutionary processes. During vertebrate evolution, the skin has played a crucial role, displaying a wide diversity of essential functions. To unravel the molecular basis of skin specialisations and adaptations, we compared gene expression in the skin with eight other tissues in a phylogenetically and ecologically diverse species sample of one of the most neglected vertebrate groups, the caecilian amphibians (order Gymnophiona). Results: The skin of the five studied caecilian species showed a distinct gene expression profile reflecting its developmental origin and showing similarities to other epithelial tissues. We identified 59 sequences with conserved enhanced expression in the skin that might be associated with caecilian dermal specialisations. Some of the upregulated genes shared expression patterns with human skin and potentially are involved in skin functions across vertebrates. Variation trends in gene expression were detected between mid and posterior body skin suggesting different functions between body regions. Several candidate biologically active peptides were also annotated. Conclusions: Our study provides the first atlas of differentially expressed sequences in caecilian tissues and a baseline to explore the molecular basis of the skin functions in caecilian amphibians, and more broadly in vertebrates.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7894
url https://hdl.handle.net/20.500.14352/7894
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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