Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives

In recent years, research has been focusing on strategies to counteract inflammatory processes and age-related diseases(1). During ageing, a low-grade systemic inflammation is often associated to an altered intestinal permeability (IP) a condition that has been shown to promote inflammation possibly...

Descripción completa

Detalles Bibliográficos
Autores: Bernardi, Stefano, Del Bo, Cristian, Guglielmetti, Simone, Gargari, Giorgio, Cherubini, Antonio, Kroon, Paul A., Kirkup, Benjamin, Hidalgo Liberona, Nicole, Peron, Gregorio, González-Domínguez, Raúl, Andrés Lacueva, Ma. Cristina, Riso, Patrizia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/184960
Acceso en línea:https://hdl.handle.net/2445/184960
Access Level:acceso abierto
Palabra clave:Persones grans
Polifenols
Malalties inflamatòries intestinals
Microbiota
Envelliment
Older people
Polyphenols
Inflammatory bowel diseases
Aging
id ES_8b4bfab5810a7ff0fb2014bf081f2a7d
oai_identifier_str oai:recercat.cat:2445/184960
network_acronym_str ES
network_name_str España
repository_id_str
spelling Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectivesBernardi, StefanoDel Bo, CristianGuglielmetti, SimoneGargari, GiorgioCherubini, AntonioKroon, Paul A.Kirkup, BenjaminHidalgo Liberona, NicolePeron, GregorioGonzález-Domínguez, RaúlAndrés Lacueva, Ma. CristinaRiso, PatriziaPersones gransPolifenolsMalalties inflamatòries intestinalsMicrobiotaEnvellimentOlder peoplePolyphenolsInflammatory bowel diseasesMicrobiotaAgingIn recent years, research has been focusing on strategies to counteract inflammatory processes and age-related diseases(1). During ageing, a low-grade systemic inflammation is often associated to an altered intestinal permeability (IP) a condition that has been shown to promote inflammation possibly through the translocation of dietary and bacterial factors into the blood stream that activates the immune system(2).In this regard, dietary pattern and environmental factors could play a fundamental role because of their potential ability to modulate inflammation, IP and the gut microbial ecosystem (GME). Moreover, it has been hypothesized that bioactive compounds such as polyphenols may affect IP and GME(3).The MaPLE project (Microbiome mAnipulation through Polyphenols for managing gut Leakiness in the Elderly) aimed to investigate the hypothesis that a polyphenol-rich diet can improve IP condition in a target population with beneficial changes at intestine and systemic level. To this aim, a randomised, controlled, crossover dietary intervention study (8-week polyphenol-rich diet versus 8-week control diet, separated by a wash-out period) was carried out in a group of older subjects (> 60 years) living in a well-controlled setting (i.e. nursing home). Markers related with IP, inflammation, oxidative stress, vascular function and intestinal microbial ecosystem were investigated in serum, urine and/or fecal samples. Moreover, blood bacteria DNAemia, and serum/urine metabolomics has been assessed. Moreover, a consistent nutritional evaluation of the standard menu (provided by the nursing home) and of weighed food diaries was performed, providing also data on actual polyphenol intake during the intervention. The results show there were higher levels of IP in the older subjects, and that the polyphenol-enriched diet changed the levels of serum zonulin, a marker of IP. In addition, an association between zonulin and blood bacterial load was demonstrated. Ongoing in vitro and in vivo experiments are exploring the potential effects of different polyphenols on IP and the mechanisms involved. The MaPLE project will generate new data to improve the understanding on the role of polyphenols in the modulation of intestinal microbiome and its interactions with the host.Cambridge University Press2022202220202022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/184960Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1017/S002966512000484XProceedings of the Nutrition Society, 2020, vol. 79, num. OCE2, p. E535-E535https://doi.org/10.1017/S002966512000484X(c) Bernardi, Stefano et al., 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1849602026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
title Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
spellingShingle Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
Bernardi, Stefano
Persones grans
Polifenols
Malalties inflamatòries intestinals
Microbiota
Envelliment
Older people
Polyphenols
Inflammatory bowel diseases
Microbiota
Aging
title_short Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
title_full Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
title_fullStr Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
title_full_unstemmed Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
title_sort Intestinal permeability modulation through a polyphenol-rich dietary pattern in older subjects: MaPLE project outcomes and perspectives
dc.creator.none.fl_str_mv Bernardi, Stefano
Del Bo, Cristian
Guglielmetti, Simone
Gargari, Giorgio
Cherubini, Antonio
Kroon, Paul A.
Kirkup, Benjamin
Hidalgo Liberona, Nicole
Peron, Gregorio
González-Domínguez, Raúl
Andrés Lacueva, Ma. Cristina
Riso, Patrizia
author Bernardi, Stefano
author_facet Bernardi, Stefano
Del Bo, Cristian
Guglielmetti, Simone
Gargari, Giorgio
Cherubini, Antonio
Kroon, Paul A.
Kirkup, Benjamin
Hidalgo Liberona, Nicole
Peron, Gregorio
González-Domínguez, Raúl
Andrés Lacueva, Ma. Cristina
Riso, Patrizia
author_role author
author2 Del Bo, Cristian
Guglielmetti, Simone
Gargari, Giorgio
Cherubini, Antonio
Kroon, Paul A.
Kirkup, Benjamin
Hidalgo Liberona, Nicole
Peron, Gregorio
González-Domínguez, Raúl
Andrés Lacueva, Ma. Cristina
Riso, Patrizia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Persones grans
Polifenols
Malalties inflamatòries intestinals
Microbiota
Envelliment
Older people
Polyphenols
Inflammatory bowel diseases
Microbiota
Aging
topic Persones grans
Polifenols
Malalties inflamatòries intestinals
Microbiota
Envelliment
Older people
Polyphenols
Inflammatory bowel diseases
Microbiota
Aging
description In recent years, research has been focusing on strategies to counteract inflammatory processes and age-related diseases(1). During ageing, a low-grade systemic inflammation is often associated to an altered intestinal permeability (IP) a condition that has been shown to promote inflammation possibly through the translocation of dietary and bacterial factors into the blood stream that activates the immune system(2).In this regard, dietary pattern and environmental factors could play a fundamental role because of their potential ability to modulate inflammation, IP and the gut microbial ecosystem (GME). Moreover, it has been hypothesized that bioactive compounds such as polyphenols may affect IP and GME(3).The MaPLE project (Microbiome mAnipulation through Polyphenols for managing gut Leakiness in the Elderly) aimed to investigate the hypothesis that a polyphenol-rich diet can improve IP condition in a target population with beneficial changes at intestine and systemic level. To this aim, a randomised, controlled, crossover dietary intervention study (8-week polyphenol-rich diet versus 8-week control diet, separated by a wash-out period) was carried out in a group of older subjects (> 60 years) living in a well-controlled setting (i.e. nursing home). Markers related with IP, inflammation, oxidative stress, vascular function and intestinal microbial ecosystem were investigated in serum, urine and/or fecal samples. Moreover, blood bacteria DNAemia, and serum/urine metabolomics has been assessed. Moreover, a consistent nutritional evaluation of the standard menu (provided by the nursing home) and of weighed food diaries was performed, providing also data on actual polyphenol intake during the intervention. The results show there were higher levels of IP in the older subjects, and that the polyphenol-enriched diet changed the levels of serum zonulin, a marker of IP. In addition, an association between zonulin and blood bacterial load was demonstrated. Ongoing in vitro and in vivo experiments are exploring the potential effects of different polyphenols on IP and the mechanisms involved. The MaPLE project will generate new data to improve the understanding on the role of polyphenols in the modulation of intestinal microbiome and its interactions with the host.
publishDate 2020
dc.date.none.fl_str_mv 2020
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184960
url https://hdl.handle.net/2445/184960
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/S002966512000484X
Proceedings of the Nutrition Society, 2020, vol. 79, num. OCE2, p. E535-E535
https://doi.org/10.1017/S002966512000484X
dc.rights.none.fl_str_mv (c) Bernardi, Stefano et al., 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Bernardi, Stefano et al., 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412798302257152
score 15.81155

Similares en LA Referencia