Tubulin and actin interplay at the T cell and antigen-presenting cell interface

T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for different molecules. The crosstalk between both skele...

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Detalhes bibliográficos
Autores: Martin-Cofreces, Noa B., Alarcón, Balbino, Sanchez-Madrid, Francisco
Formato: artículo
Fecha de publicación:2011
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7765
Acesso em linha:http://hdl.handle.net/20.500.12105/7765
Access Level:acceso abierto
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spelling Tubulin and actin interplay at the T cell and antigen-presenting cell interfaceMartin-Cofreces, Noa B.Alarcón, BalbinoSanchez-Madrid, FranciscoT cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for different molecules. The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhesion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating the T-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of the different signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally, they can also be important for regulating the endocytosis, recycling, and degradation of the T cell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off.Ministerio de Ciencia e Innovación (España)Comunidad de Madrid (España)Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)Fundación ProCNIC20192019-06-1220112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7765reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/77652026-06-12T12:43:37Z
dc.title.none.fl_str_mv Tubulin and actin interplay at the T cell and antigen-presenting cell interface
title Tubulin and actin interplay at the T cell and antigen-presenting cell interface
spellingShingle Tubulin and actin interplay at the T cell and antigen-presenting cell interface
Martin-Cofreces, Noa B.
title_short Tubulin and actin interplay at the T cell and antigen-presenting cell interface
title_full Tubulin and actin interplay at the T cell and antigen-presenting cell interface
title_fullStr Tubulin and actin interplay at the T cell and antigen-presenting cell interface
title_full_unstemmed Tubulin and actin interplay at the T cell and antigen-presenting cell interface
title_sort Tubulin and actin interplay at the T cell and antigen-presenting cell interface
dc.creator.none.fl_str_mv Martin-Cofreces, Noa B.
Alarcón, Balbino
Sanchez-Madrid, Francisco
author Martin-Cofreces, Noa B.
author_facet Martin-Cofreces, Noa B.
Alarcón, Balbino
Sanchez-Madrid, Francisco
author_role author
author2 Alarcón, Balbino
Sanchez-Madrid, Francisco
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Comunidad de Madrid (España)
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
Fundación ProCNIC
description T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for different molecules. The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhesion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating the T-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of the different signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally, they can also be important for regulating the endocytosis, recycling, and degradation of the T cell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01
2011
2011-01-01
2019
2019-06-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7765
url http://hdl.handle.net/20.500.12105/7765
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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