Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation
Assessing changes suffered by the cornea as keratoconus progresses has proven to be vital for this disease diagnosis and treatment. 'is study determines the corneal biometric profile in eyes considered as affected by keratoconus (KC) showing severe visual limitation, by means of in vivo 3D mode...
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad Politécnica de Cartagena(UPCT) |
| Repositorio: | Repositorio Digital UPCT |
| OAI Identifier: | oai:repositorio.upct.es:10317/8968 |
| Acesso em linha: | http://hdl.handle.net/10317/8968 https://www.hindawi.com/journals/joph/2019/8731626/ |
| Access Level: | acceso abierto |
| Palavra-chave: | Ophthalmology Early keratoconus Keratoconus (KC) Corneal topographer Expresión Gráfica en Ingeniería 1203.09 Diseño Con Ayuda del Ordenador 3201.09 Oftalmología |
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Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitationVelázquez Blázquez, José SebastiánCavas Martínez, FranciscoAlió del Barrio, Jorge LuisGarcía Fernández Pacheco, DanielAlió Sanz, Jorge LucianoOphthalmologyEarly keratoconusKeratoconus (KC)Corneal topographerExpresión Gráfica en Ingeniería1203.09 Diseño Con Ayuda del Ordenador3201.09 OftalmologíaAssessing changes suffered by the cornea as keratoconus progresses has proven to be vital for this disease diagnosis and treatment. 'is study determines the corneal biometric profile in eyes considered as affected by keratoconus (KC) showing severe visual limitation, by means of in vivo 3D modelling techniques. 'is observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. Receiving operator curves were used to determine sensitivity and specificity of selected indices, being anterior and posterior apex deviations the ones which reached the highest area under the curve, both with very high sensitivity (96.7% and 90%, respectively) and specificity (94.0% and 99.9%, respectively). 'e results suggest that once severe visual loss appears, anterior corneal topography should be considered for a more accurate diagnosis of clinical KC, being anterior apex deviation the key metric discriminant. 'is study can be a useful tool for KC classification, helping doctors in diagnosing severe cases of the disease, and can help to characterize corneal changes that appear when severe KC is developed and how they relate with vision deterioration.This publication has been carried out in the framework of the Thematic Network for Cooperative Research in Health (RETICS) reference number RD16/0008/0012 financed by the Carlos III Health Institute-General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2013–2016) and the European Regional Development Fund (FEDER).Ed. Hindawi PublishingInstituto de salud Carlos IIIFondo Europeo de Desarrollo Regional (FEDER)202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10317/8968https://www.hindawi.com/journals/joph/2019/8731626/reponame:Repositorio Digital UPCTinstname:Universidad Politécnica de Cartagena(UPCT)InglésAnálisis morfogeométrico de la estructura hemiesférica del segmento anterior del ojo humano y su aplicación clínicahttp://hdl.handle.net/10317/9086Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.upct.es:10317/89682026-05-15T06:39:02Z |
| dc.title.none.fl_str_mv |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| title |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| spellingShingle |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation Velázquez Blázquez, José Sebastián Ophthalmology Early keratoconus Keratoconus (KC) Corneal topographer Expresión Gráfica en Ingeniería 1203.09 Diseño Con Ayuda del Ordenador 3201.09 Oftalmología |
| title_short |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| title_full |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| title_fullStr |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| title_full_unstemmed |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| title_sort |
Assessment of the association between In vivo corneal morphogeometrical changes and keratoconus eyes with severe visual limitation |
| dc.creator.none.fl_str_mv |
Velázquez Blázquez, José Sebastián Cavas Martínez, Francisco Alió del Barrio, Jorge Luis García Fernández Pacheco, Daniel Alió Sanz, Jorge Luciano |
| author |
Velázquez Blázquez, José Sebastián |
| author_facet |
Velázquez Blázquez, José Sebastián Cavas Martínez, Francisco Alió del Barrio, Jorge Luis García Fernández Pacheco, Daniel Alió Sanz, Jorge Luciano |
| author_role |
author |
| author2 |
Cavas Martínez, Francisco Alió del Barrio, Jorge Luis García Fernández Pacheco, Daniel Alió Sanz, Jorge Luciano |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de salud Carlos III Fondo Europeo de Desarrollo Regional (FEDER) |
| dc.subject.none.fl_str_mv |
Ophthalmology Early keratoconus Keratoconus (KC) Corneal topographer Expresión Gráfica en Ingeniería 1203.09 Diseño Con Ayuda del Ordenador 3201.09 Oftalmología |
| topic |
Ophthalmology Early keratoconus Keratoconus (KC) Corneal topographer Expresión Gráfica en Ingeniería 1203.09 Diseño Con Ayuda del Ordenador 3201.09 Oftalmología |
| description |
Assessing changes suffered by the cornea as keratoconus progresses has proven to be vital for this disease diagnosis and treatment. 'is study determines the corneal biometric profile in eyes considered as affected by keratoconus (KC) showing severe visual limitation, by means of in vivo 3D modelling techniques. 'is observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. Receiving operator curves were used to determine sensitivity and specificity of selected indices, being anterior and posterior apex deviations the ones which reached the highest area under the curve, both with very high sensitivity (96.7% and 90%, respectively) and specificity (94.0% and 99.9%, respectively). 'e results suggest that once severe visual loss appears, anterior corneal topography should be considered for a more accurate diagnosis of clinical KC, being anterior apex deviation the key metric discriminant. 'is study can be a useful tool for KC classification, helping doctors in diagnosing severe cases of the disease, and can help to characterize corneal changes that appear when severe KC is developed and how they relate with vision deterioration. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10317/8968 https://www.hindawi.com/journals/joph/2019/8731626/ |
| url |
http://hdl.handle.net/10317/8968 https://www.hindawi.com/journals/joph/2019/8731626/ |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Análisis morfogeométrico de la estructura hemiesférica del segmento anterior del ojo humano y su aplicación clínica http://hdl.handle.net/10317/9086 |
| dc.rights.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-SinDerivadas 3.0 España http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Ed. Hindawi Publishing |
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Ed. Hindawi Publishing |
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reponame:Repositorio Digital UPCT instname:Universidad Politécnica de Cartagena(UPCT) |
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Universidad Politécnica de Cartagena(UPCT) |
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Repositorio Digital UPCT |
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Repositorio Digital UPCT |
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