Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk

Human breast milk (HBM) has a beneficial impact on health programming, growth and neurodevelopment of newborns. Increase in iodine intake is recommended for pregnant women in order to produce enough thyroid hormones to meet foetal requirements. In this work, a combined analytical multiplatform based...

Descripción completa

Detalles Bibliográficos
Autores: Arias Borrego, Ana, Velasco, Inés, Gómez Ariza, José Luis, García Barrera, Tamara
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Huelva (UHU)
Repositorio:Arias Montano. Repositorio Institucional de la Universidad de Huelva
Idioma:inglés
OAI Identifier:oai:ariasmontano.uhu.es:10272/20398
Acceso en línea:http://hdl.handle.net/10272/20398
Access Level:acceso abierto
Palabra clave:Human breast milk
Iodine
Inductively coupled plasma mass spectrometry
Metabolomics
Trace elements
id ES_8b3cb8f99d78005ff33da1646b6bce20
oai_identifier_str oai:ariasmontano.uhu.es:10272/20398
network_acronym_str ES
network_name_str España
repository_id_str
spelling Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milkArias Borrego, AnaVelasco, InésGómez Ariza, José LuisGarcía Barrera, TamaraHuman breast milkIodineInductively coupled plasma mass spectrometryMetabolomicsTrace elementsHuman breast milk (HBM) has a beneficial impact on health programming, growth and neurodevelopment of newborns. Increase in iodine intake is recommended for pregnant women in order to produce enough thyroid hormones to meet foetal requirements. In this work, a combined analytical multiplatform based on gas chromatography coupled to mass spectrometry and ultra-high performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry has been applied in the first metabolomic study of HBM of iodinedeficient women. In addition, the elemental composition of HBM has been determined by inductively coupled plasma triple quadrupole mass spectrometry. Remarkably, 31 metabolites with important biological roles (e.g.glycerophospholipids for neurodevelopment) were seen to be altered in the HBM of iodine-deficient women. The main metabolic pathways altered include lipid metabolism, amino acid cycle, the tricarboxylic acid cycle and glycolysis. Additionally, the concentration of selenium, zinc and copper were seen to be significantly lower in HBM of iodine-deficient women.Elsevier20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10272/20398reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelvainstname:Universidad de Huelva (UHU)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ariasmontano.uhu.es:10272/203982026-06-02T14:58:11Z
dc.title.none.fl_str_mv Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
title Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
spellingShingle Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
Arias Borrego, Ana
Human breast milk
Iodine
Inductively coupled plasma mass spectrometry
Metabolomics
Trace elements
title_short Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
title_full Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
title_fullStr Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
title_full_unstemmed Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
title_sort Iodine deficiency disturbs the metabolic profile and elemental composition of human breast milk
dc.creator.none.fl_str_mv Arias Borrego, Ana
Velasco, Inés
Gómez Ariza, José Luis
García Barrera, Tamara
author Arias Borrego, Ana
author_facet Arias Borrego, Ana
Velasco, Inés
Gómez Ariza, José Luis
García Barrera, Tamara
author_role author
author2 Velasco, Inés
Gómez Ariza, José Luis
García Barrera, Tamara
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Human breast milk
Iodine
Inductively coupled plasma mass spectrometry
Metabolomics
Trace elements
topic Human breast milk
Iodine
Inductively coupled plasma mass spectrometry
Metabolomics
Trace elements
description Human breast milk (HBM) has a beneficial impact on health programming, growth and neurodevelopment of newborns. Increase in iodine intake is recommended for pregnant women in order to produce enough thyroid hormones to meet foetal requirements. In this work, a combined analytical multiplatform based on gas chromatography coupled to mass spectrometry and ultra-high performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry has been applied in the first metabolomic study of HBM of iodinedeficient women. In addition, the elemental composition of HBM has been determined by inductively coupled plasma triple quadrupole mass spectrometry. Remarkably, 31 metabolites with important biological roles (e.g.glycerophospholipids for neurodevelopment) were seen to be altered in the HBM of iodine-deficient women. The main metabolic pathways altered include lipid metabolism, amino acid cycle, the tricarboxylic acid cycle and glycolysis. Additionally, the concentration of selenium, zinc and copper were seen to be significantly lower in HBM of iodine-deficient women.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10272/20398
url http://hdl.handle.net/10272/20398
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname:Universidad de Huelva (UHU)
instname_str Universidad de Huelva (UHU)
reponame_str Arias Montano. Repositorio Institucional de la Universidad de Huelva
collection Arias Montano. Repositorio Institucional de la Universidad de Huelva
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412793718931456
score 15,812429

Similares en LA Referencia