Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems

Producción Científica

Detalles Bibliográficos
Autores: Carvajal García-Pando, Alfonso, Macías Saint-Gerons, Diego, Salado Valdivieso, María Ines, Sáinz Gil, María, Ortega, Sara, Campo, C., García del Pozo, Javier, Martín Arias, Luis Hermenegildo, Velasco Martín, Alfonso, Gonçalves, R., Pombal, R., Carmona, R.
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/9054
Acceso en línea:https://doi.org/10.1038/clpt.2008.269
http://uvadoc.uva.es/handle/10324/9054
Access Level:acceso abierto
Palabra clave:Insuficiencia cardiaca
Rupatadina
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spelling Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance SystemsCarvajal García-Pando, AlfonsoMacías Saint-Gerons, DiegoSalado Valdivieso, María InesSáinz Gil, MaríaOrtega, SaraCampo, C.García del Pozo, JavierMartín Arias, Luis HermenegildoVelasco Martín, AlfonsoGonçalves, R.Pombal, R.Carmona, R.Insuficiencia cardiacaRupatadinaProducción CientíficaWe searched the Spanish and Portuguese pharmacovigilance databases for spontaneous case reports of heart rhythm disturbances associated with rupatadine and other new H1 antihistamines. Five cases were found involving patients treated with rupatadine (13.9% of all reports relating to this drug). In all five cases, the reaction started after exposure and resolved when the drug was discontinued. In two cases, rupatadine was the only medication being taken by the patient, and no other condition that could explain the heart rhythm disturbances was diagnosed. The reporting odds ratio was 3.2 (95% confidence interval, 1.0-10.5). The reporting rate was 2 cases per 100,000 patients treated per year (95% confidence interval, 0.4-6.0). These results suggest a causal relationship between rupatadine and heart rhythm disturbancesJunta de Castilla y León. Consejería de Sanidad. Dirección General de Salud Pública e Investigación, Desarrollo e Innovación.American Society for Clinical Pharmacology and Therapeutics2009info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1038/clpt.2008.269http://uvadoc.uva.es/handle/10324/9054reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidInglésinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/90542026-06-13T12:44:47Z
dc.title.none.fl_str_mv Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
title Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
spellingShingle Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
Carvajal García-Pando, Alfonso
Insuficiencia cardiaca
Rupatadina
title_short Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
title_full Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
title_fullStr Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
title_full_unstemmed Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
title_sort Heart rhythm risturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance Systems
dc.creator.none.fl_str_mv Carvajal García-Pando, Alfonso
Macías Saint-Gerons, Diego
Salado Valdivieso, María Ines
Sáinz Gil, María
Ortega, Sara
Campo, C.
García del Pozo, Javier
Martín Arias, Luis Hermenegildo
Velasco Martín, Alfonso
Gonçalves, R.
Pombal, R.
Carmona, R.
author Carvajal García-Pando, Alfonso
author_facet Carvajal García-Pando, Alfonso
Macías Saint-Gerons, Diego
Salado Valdivieso, María Ines
Sáinz Gil, María
Ortega, Sara
Campo, C.
García del Pozo, Javier
Martín Arias, Luis Hermenegildo
Velasco Martín, Alfonso
Gonçalves, R.
Pombal, R.
Carmona, R.
author_role author
author2 Macías Saint-Gerons, Diego
Salado Valdivieso, María Ines
Sáinz Gil, María
Ortega, Sara
Campo, C.
García del Pozo, Javier
Martín Arias, Luis Hermenegildo
Velasco Martín, Alfonso
Gonçalves, R.
Pombal, R.
Carmona, R.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiencia cardiaca
Rupatadina
topic Insuficiencia cardiaca
Rupatadina
description Producción Científica
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1038/clpt.2008.269
http://uvadoc.uva.es/handle/10324/9054
url https://doi.org/10.1038/clpt.2008.269
http://uvadoc.uva.es/handle/10324/9054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Clinical Pharmacology and Therapeutics
publisher.none.fl_str_mv American Society for Clinical Pharmacology and Therapeutics
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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