Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment

Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship with school performance and whether these links are explained, in part, by the genetic liability of EA. H...

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Autores: Cabana-Domínguez, Judit|||0000-0002-4732-7284, Bosch, Rosa|||0000-0002-7596-183X, Soler Artigas, María|||0000-0002-3213-1107, Alemany, Sílvia|||0000-0002-7925-6767, Llonga, Natalia|||0000-0003-4325-6201, Vilar-Ribó, L.|||0000-0001-8758-523X, Carabí-Gassol, Pau, Arribas, Lorena|||0000-0002-9683-9999, Macias-Chimborazo, Valeria, Español-Martín, Gemma|||0000-0002-2362-8189, del Castillo, Clara, Martínez, Laura, Pagerols, Mireia|||0000-0003-0856-6247, Pagespetit, Èlia, Prat, Raquel|||0000-0001-8097-6617, Puigbó, Julia, Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350, Casas Brugué, Miquel|||0000-0003-3496-8522, Ribasés Haro, Marta|||0000-0003-1039-1116
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:306938
Acceso en línea:https://ddd.uab.cat/record/306938
https://dx.doi.org/urn:doi:10.1038/s41380-024-02582-w
Access Level:acceso abierto
Palabra clave:ADHD
Autism spectrum disorders
Genetics
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spelling Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainmentCabana-Domínguez, Judit|||0000-0002-4732-7284Bosch, Rosa|||0000-0002-7596-183XSoler Artigas, María|||0000-0002-3213-1107Alemany, Sílvia|||0000-0002-7925-6767Llonga, Natalia|||0000-0003-4325-6201Vilar-Ribó, L.|||0000-0001-8758-523XCarabí-Gassol, PauArribas, Lorena|||0000-0002-9683-9999Macias-Chimborazo, ValeriaEspañol-Martín, Gemma|||0000-0002-2362-8189del Castillo, ClaraMartínez, LauraPagerols, Mireia|||0000-0003-0856-6247Pagespetit, ÈliaPrat, Raquel|||0000-0001-8097-6617Puigbó, JuliaRamos-Quiroga, Josep Antoni|||0000-0003-1622-0350Casas Brugué, Miquel|||0000-0003-3496-8522Ribasés Haro, Marta|||0000-0003-1039-1116ADHDAutism spectrum disordersGeneticsAttention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship with school performance and whether these links are explained, in part, by the genetic liability of EA. Here, we aim to dissect the polygenic contribution of ADHD and ASD to school performance, early manifestation of psychopathology and other psychiatric disorders and related traits by their relationship with EA. To do so, we tested the association of polygenic scores for EA, ADHD and ASD with school performance, assessed whether the contribution of the genetic liability of ADHD and ASD to school performance is influenced by the genetic liability of EA, and evaluated the role of EA in the genetic overlap between ADHD and ASD with early manifestation of psychopathology and other psychiatric disorders and related traits in a sample of 4,278 school-age children. The genetic liability for ADHD and ASD dissected by their relationship with EA show differences in their association with school performance and early manifestation of psychopathology, partly mediated by ADHD and ASD symptoms. Genetic variation with concordant effects in ASD and EA contributes to better school performance, while the genetic variation with discordant effects in ADHD or ASD and EA is associated with poor school performance and higher rates of emotional and behavioral problems. Our results strongly support the usage of the genetic load for EA to dissect the genetic and phenotypic heterogeneity of ADHD and ASD, which could help to fill the gap of knowledge of mechanisms underlying educational outcomes. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/306938https://dx.doi.org/urn:doi:10.1038/s41380-024-02582-wreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00041Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00464Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/00404Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/00026Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1461Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00840Fundació la Marató de TV3 https://doi.org/10.13039/100008666 202228-30Fundació la Marató de TV3 https://doi.org/10.13039/100008666 202228-31"la Caixa" Foundation https://doi.org/10.13039/100010434 PERISSLT006/17/285open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3069382026-06-06T12:50:31Z
dc.title.none.fl_str_mv Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
title Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
spellingShingle Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
Cabana-Domínguez, Judit|||0000-0002-4732-7284
ADHD
Autism spectrum disorders
Genetics
title_short Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
title_full Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
title_fullStr Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
title_full_unstemmed Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
title_sort Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
dc.creator.none.fl_str_mv Cabana-Domínguez, Judit|||0000-0002-4732-7284
Bosch, Rosa|||0000-0002-7596-183X
Soler Artigas, María|||0000-0002-3213-1107
Alemany, Sílvia|||0000-0002-7925-6767
Llonga, Natalia|||0000-0003-4325-6201
Vilar-Ribó, L.|||0000-0001-8758-523X
Carabí-Gassol, Pau
Arribas, Lorena|||0000-0002-9683-9999
Macias-Chimborazo, Valeria
Español-Martín, Gemma|||0000-0002-2362-8189
del Castillo, Clara
Martínez, Laura
Pagerols, Mireia|||0000-0003-0856-6247
Pagespetit, Èlia
Prat, Raquel|||0000-0001-8097-6617
Puigbó, Julia
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Casas Brugué, Miquel|||0000-0003-3496-8522
Ribasés Haro, Marta|||0000-0003-1039-1116
author Cabana-Domínguez, Judit|||0000-0002-4732-7284
author_facet Cabana-Domínguez, Judit|||0000-0002-4732-7284
Bosch, Rosa|||0000-0002-7596-183X
Soler Artigas, María|||0000-0002-3213-1107
Alemany, Sílvia|||0000-0002-7925-6767
Llonga, Natalia|||0000-0003-4325-6201
Vilar-Ribó, L.|||0000-0001-8758-523X
Carabí-Gassol, Pau
Arribas, Lorena|||0000-0002-9683-9999
Macias-Chimborazo, Valeria
Español-Martín, Gemma|||0000-0002-2362-8189
del Castillo, Clara
Martínez, Laura
Pagerols, Mireia|||0000-0003-0856-6247
Pagespetit, Èlia
Prat, Raquel|||0000-0001-8097-6617
Puigbó, Julia
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Casas Brugué, Miquel|||0000-0003-3496-8522
Ribasés Haro, Marta|||0000-0003-1039-1116
author_role author
author2 Bosch, Rosa|||0000-0002-7596-183X
Soler Artigas, María|||0000-0002-3213-1107
Alemany, Sílvia|||0000-0002-7925-6767
Llonga, Natalia|||0000-0003-4325-6201
Vilar-Ribó, L.|||0000-0001-8758-523X
Carabí-Gassol, Pau
Arribas, Lorena|||0000-0002-9683-9999
Macias-Chimborazo, Valeria
Español-Martín, Gemma|||0000-0002-2362-8189
del Castillo, Clara
Martínez, Laura
Pagerols, Mireia|||0000-0003-0856-6247
Pagespetit, Èlia
Prat, Raquel|||0000-0001-8097-6617
Puigbó, Julia
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Casas Brugué, Miquel|||0000-0003-3496-8522
Ribasés Haro, Marta|||0000-0003-1039-1116
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADHD
Autism spectrum disorders
Genetics
topic ADHD
Autism spectrum disorders
Genetics
description Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship with school performance and whether these links are explained, in part, by the genetic liability of EA. Here, we aim to dissect the polygenic contribution of ADHD and ASD to school performance, early manifestation of psychopathology and other psychiatric disorders and related traits by their relationship with EA. To do so, we tested the association of polygenic scores for EA, ADHD and ASD with school performance, assessed whether the contribution of the genetic liability of ADHD and ASD to school performance is influenced by the genetic liability of EA, and evaluated the role of EA in the genetic overlap between ADHD and ASD with early manifestation of psychopathology and other psychiatric disorders and related traits in a sample of 4,278 school-age children. The genetic liability for ADHD and ASD dissected by their relationship with EA show differences in their association with school performance and early manifestation of psychopathology, partly mediated by ADHD and ASD symptoms. Genetic variation with concordant effects in ASD and EA contributes to better school performance, while the genetic variation with discordant effects in ADHD or ASD and EA is associated with poor school performance and higher rates of emotional and behavioral problems. Our results strongly support the usage of the genetic load for EA to dissect the genetic and phenotypic heterogeneity of ADHD and ASD, which could help to fill the gap of knowledge of mechanisms underlying educational outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/306938
https://dx.doi.org/urn:doi:10.1038/s41380-024-02582-w
url https://ddd.uab.cat/record/306938
https://dx.doi.org/urn:doi:10.1038/s41380-024-02582-w
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00041
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00464
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/00404
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/00026
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1461
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00840
Fundació la Marató de TV3 https://doi.org/10.13039/100008666 202228-30
Fundació la Marató de TV3 https://doi.org/10.13039/100008666 202228-31
"la Caixa" Foundation https://doi.org/10.13039/100010434 PERISSLT006/17/285
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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