Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations

Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulati...

Descripción completa

Detalles Bibliográficos
Autores: Pitulice, Laura, Vilaseca i Font, Eudald, Isvoran, Adriana, Garcés, Josep Lluís, Mas i Pujadas, Francesc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/158877
Acceso en línea:https://hdl.handle.net/2445/158877
Access Level:acceso abierto
Palabra clave:Mètode de Montecarlo
Mètodes de simulació
Cinètica enzimàtica
Monte Carlo method
Simulation methods
Enzyme kinetics
id ES_8b04bb8d4e45bca5827b4cac207c4ba2
oai_identifier_str oai:recercat.cat:2445/158877
network_acronym_str ES
network_name_str España
repository_id_str
spelling Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulationsPitulice, LauraVilaseca i Font, EudaldIsvoran, AdrianaGarcés, Josep LluísMas i Pujadas, FrancescMètode de MontecarloMètodes de simulacióCinètica enzimàticaMonte Carlo methodSimulation methodsEnzyme kineticsUsing Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulation data are analyzed in terms of parameters describing the time dependence of the rate coefficient. Our results indicate a fractal like kinetics with different degrees of fractality depending on crowders features. Even though small, when crowders mobility rises kinetics fractality decreases due to enhancement of diffusional movements of the reactants. Instead, increasing the crowders density in the system kinetics fractality presents a smooth growth as less free volume is available for reactants.Universitatea de Vest din Timişoara2020202020112020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/158877Articles publicats en revistes (Ciència dels Materials i Química Física)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a:Annals of West University of Timisoara. Series Chemistry, 2011, vol. 20, num. 2, p. 95-104(c) Universitatea de Vest din Timişoara, 2011info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1588772026-05-29T05:05:01Z
dc.title.none.fl_str_mv Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
title Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
spellingShingle Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
Pitulice, Laura
Mètode de Montecarlo
Mètodes de simulació
Cinètica enzimàtica
Monte Carlo method
Simulation methods
Enzyme kinetics
title_short Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
title_full Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
title_fullStr Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
title_full_unstemmed Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
title_sort Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
dc.creator.none.fl_str_mv Pitulice, Laura
Vilaseca i Font, Eudald
Isvoran, Adriana
Garcés, Josep Lluís
Mas i Pujadas, Francesc
author Pitulice, Laura
author_facet Pitulice, Laura
Vilaseca i Font, Eudald
Isvoran, Adriana
Garcés, Josep Lluís
Mas i Pujadas, Francesc
author_role author
author2 Vilaseca i Font, Eudald
Isvoran, Adriana
Garcés, Josep Lluís
Mas i Pujadas, Francesc
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mètode de Montecarlo
Mètodes de simulació
Cinètica enzimàtica
Monte Carlo method
Simulation methods
Enzyme kinetics
topic Mètode de Montecarlo
Mètodes de simulació
Cinètica enzimàtica
Monte Carlo method
Simulation methods
Enzyme kinetics
description Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulation data are analyzed in terms of parameters describing the time dependence of the rate coefficient. Our results indicate a fractal like kinetics with different degrees of fractality depending on crowders features. Even though small, when crowders mobility rises kinetics fractality decreases due to enhancement of diffusional movements of the reactants. Instead, increasing the crowders density in the system kinetics fractality presents a smooth growth as less free volume is available for reactants.
publishDate 2011
dc.date.none.fl_str_mv 2011
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/158877
url https://hdl.handle.net/2445/158877
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a:
Annals of West University of Timisoara. Series Chemistry, 2011, vol. 20, num. 2, p. 95-104
dc.rights.none.fl_str_mv (c) Universitatea de Vest din Timişoara, 2011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Universitatea de Vest din Timişoara, 2011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitatea de Vest din Timişoara
publisher.none.fl_str_mv Universitatea de Vest din Timişoara
dc.source.none.fl_str_mv Articles publicats en revistes (Ciència dels Materials i Química Física)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412776179400704
score 15,811543

Similares en LA Referencia