Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes
Antioxidant-based treatments are emerging as an interesting approach to possibly counteract obesity fat accumulation complications, since this is accompanied by an increased systemic oxidative stress. The aim of this study was to analyze specific metabolic effects of vitamin C (VC) on epididymal pri...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/28186 |
| Acceso en línea: | https://hdl.handle.net/10171/28186 |
| Access Level: | acceso abierto |
| Palabra clave: | Adipocytes Antioxidants Ascorbic acid Glucose Lipid metabolism |
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Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytesGarcia-Garcia, D.F. (D. F.)|||/items/592baa9a-2828-4782-85ea-545d4766ff91Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817cMilagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebBoque, N. (Noemi)|||/items/db72d734-711b-40c8-9066-a04f57a4989bMoreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131AdipocytesAntioxidantsAscorbic acidGlucoseLipid metabolismAntioxidant-based treatments are emerging as an interesting approach to possibly counteract obesity fat accumulation complications, since this is accompanied by an increased systemic oxidative stress. The aim of this study was to analyze specific metabolic effects of vitamin C (VC) on epididymal primary rat adipocytes. Cells were isolated and incubated for 72 h in culture medium, in the absence or presence of 1.6 nM insulin, within a range of VC concentrations (5-1000 microM). Glucose- and lipid-related variables as well as the secretion/expression patterns of several obesity-related genes were assessed. It was observed that VC dose dependently inhibited glucose uptake and lactate production, and also reduced glycerol release in both control and insulin-treated cells. Also, VC caused a dramatic concentration-dependent fall in leptin secretion especially in insulin-stimulated cells. In addition, VC (200 microM) induced Cdkn1a and Casp8, partially inhibited Irs3, and together with insulin drastically reduced Gpdh (listed as Gpd1 in the MGI database) gene expressions. Finally, VC and insulin down-regulatory effects were observed on extracellular and intracellular reactive oxygen species production respectively. In summary, this experimental assay describes a specific effect of VC in isolated rat adipocytes on glucose and fat metabolism, and on the secretion/expression of important obesity-related proteins.European Society of EndocrinologyDadun. Depósito Académico Digital Universidad de Navarra20132013-03-2820102010-01-0120102010-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/28186reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/281862026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| title |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| spellingShingle |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes Garcia-Garcia, D.F. (D. F.)|||/items/592baa9a-2828-4782-85ea-545d4766ff91 Adipocytes Antioxidants Ascorbic acid Glucose Lipid metabolism |
| title_short |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| title_full |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| title_fullStr |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| title_full_unstemmed |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| title_sort |
Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes |
| dc.creator.none.fl_str_mv |
Garcia-Garcia, D.F. (D. F.)|||/items/592baa9a-2828-4782-85ea-545d4766ff91 Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Boque, N. (Noemi)|||/items/db72d734-711b-40c8-9066-a04f57a4989b Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author |
Garcia-Garcia, D.F. (D. F.)|||/items/592baa9a-2828-4782-85ea-545d4766ff91 |
| author_facet |
Garcia-Garcia, D.F. (D. F.)|||/items/592baa9a-2828-4782-85ea-545d4766ff91 Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Boque, N. (Noemi)|||/items/db72d734-711b-40c8-9066-a04f57a4989b Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author_role |
author |
| author2 |
Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Boque, N. (Noemi)|||/items/db72d734-711b-40c8-9066-a04f57a4989b Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Adipocytes Antioxidants Ascorbic acid Glucose Lipid metabolism |
| topic |
Adipocytes Antioxidants Ascorbic acid Glucose Lipid metabolism |
| description |
Antioxidant-based treatments are emerging as an interesting approach to possibly counteract obesity fat accumulation complications, since this is accompanied by an increased systemic oxidative stress. The aim of this study was to analyze specific metabolic effects of vitamin C (VC) on epididymal primary rat adipocytes. Cells were isolated and incubated for 72 h in culture medium, in the absence or presence of 1.6 nM insulin, within a range of VC concentrations (5-1000 microM). Glucose- and lipid-related variables as well as the secretion/expression patterns of several obesity-related genes were assessed. It was observed that VC dose dependently inhibited glucose uptake and lactate production, and also reduced glycerol release in both control and insulin-treated cells. Also, VC caused a dramatic concentration-dependent fall in leptin secretion especially in insulin-stimulated cells. In addition, VC (200 microM) induced Cdkn1a and Casp8, partially inhibited Irs3, and together with insulin drastically reduced Gpdh (listed as Gpd1 in the MGI database) gene expressions. Finally, VC and insulin down-regulatory effects were observed on extracellular and intracellular reactive oxygen species production respectively. In summary, this experimental assay describes a specific effect of VC in isolated rat adipocytes on glucose and fat metabolism, and on the secretion/expression of important obesity-related proteins. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010 2010-01-01 2010 2010-01-01 2013 2013-03-28 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/28186 |
| url |
https://hdl.handle.net/10171/28186 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
European Society of Endocrinology |
| publisher.none.fl_str_mv |
European Society of Endocrinology |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,301629 |