Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila

Transposable elements (TEs) are DNA sequences able to be mobilized in host genomes. They are currently recognized as the major mutation inducers because of their insertion in the target, their effect on neighboring regions, or their ectopic recombination. A large number of factors including chemical...

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Autor: García Guerreiro, María Pilar|||0000-0001-9951-1879
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:185086
Acceso en línea:https://ddd.uab.cat/record/185086
https://dx.doi.org/urn:doi:10.4161/mge.34394
Access Level:acceso abierto
Palabra clave:Drosophila
Transposable elements
Interspecific hybridization
Transposition
Genomic instability
Epigenetic factors
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spelling Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in DrosophilaGarcía Guerreiro, María Pilar|||0000-0001-9951-1879DrosophilaTransposable elementsInterspecific hybridizationTranspositionGenomic instabilityEpigenetic factorsTransposable elements (TEs) are DNA sequences able to be mobilized in host genomes. They are currently recognized as the major mutation inducers because of their insertion in the target, their effect on neighboring regions, or their ectopic recombination. A large number of factors including chemical and physical factors as well as intraspecific crosses have traditionally been identified as inducers of transposition. Besides environmental factors, interspecific crosses have also been proposed as promoters of transposition of particular TEs in plants and different animals. Our previous published work includes a genome-wide survey with the set of genomic TEs and shows that interspecific hybridization between the species Drosophila buzzatii and Drosophila koepferae induces genomic instability by transposition bursts. A high percentage of this instability corresponds to TEs belonging to classes I and II. The detailed study of three TEs (Osvaldo, Helena, and Galileo), representative of the different TE families, shows an increase of transposition in hybrids compared with parental species, that varies depending on the element. This study suggests ample variation in TE regulation mechanisms and the question is why this variation occurs. Interspecific hybridization is a genomic stressor that disrupts the stability of TEs probably contributing to a relaxation of the mechanisms controlling TEs in the Drosophila genome. In this commentary paper we will discuss these results and the molecular mechanisms that could explain these increases of transposition rates observed in interspecific Drosophila hybrids. 22014-01-0120142014-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/185086https://dx.doi.org/urn:doi:10.4161/mge.34394reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CGL2009-12912-C03-01Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CGL2010-15395open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1850862026-06-06T12:50:31Z
dc.title.none.fl_str_mv Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
title Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
spellingShingle Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
García Guerreiro, María Pilar|||0000-0001-9951-1879
Drosophila
Transposable elements
Interspecific hybridization
Transposition
Genomic instability
Epigenetic factors
title_short Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
title_full Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
title_fullStr Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
title_full_unstemmed Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
title_sort Interspecific hybridization as a genomic stressor inducing mobilization of transposable elements in Drosophila
dc.creator.none.fl_str_mv García Guerreiro, María Pilar|||0000-0001-9951-1879
author García Guerreiro, María Pilar|||0000-0001-9951-1879
author_facet García Guerreiro, María Pilar|||0000-0001-9951-1879
author_role author
dc.subject.none.fl_str_mv Drosophila
Transposable elements
Interspecific hybridization
Transposition
Genomic instability
Epigenetic factors
topic Drosophila
Transposable elements
Interspecific hybridization
Transposition
Genomic instability
Epigenetic factors
description Transposable elements (TEs) are DNA sequences able to be mobilized in host genomes. They are currently recognized as the major mutation inducers because of their insertion in the target, their effect on neighboring regions, or their ectopic recombination. A large number of factors including chemical and physical factors as well as intraspecific crosses have traditionally been identified as inducers of transposition. Besides environmental factors, interspecific crosses have also been proposed as promoters of transposition of particular TEs in plants and different animals. Our previous published work includes a genome-wide survey with the set of genomic TEs and shows that interspecific hybridization between the species Drosophila buzzatii and Drosophila koepferae induces genomic instability by transposition bursts. A high percentage of this instability corresponds to TEs belonging to classes I and II. The detailed study of three TEs (Osvaldo, Helena, and Galileo), representative of the different TE families, shows an increase of transposition in hybrids compared with parental species, that varies depending on the element. This study suggests ample variation in TE regulation mechanisms and the question is why this variation occurs. Interspecific hybridization is a genomic stressor that disrupts the stability of TEs probably contributing to a relaxation of the mechanisms controlling TEs in the Drosophila genome. In this commentary paper we will discuss these results and the molecular mechanisms that could explain these increases of transposition rates observed in interspecific Drosophila hybrids.
publishDate 2014
dc.date.none.fl_str_mv 2
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/185086
https://dx.doi.org/urn:doi:10.4161/mge.34394
url https://ddd.uab.cat/record/185086
https://dx.doi.org/urn:doi:10.4161/mge.34394
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CGL2009-12912-C03-01
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CGL2010-15395
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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