Autoanticossos contra receptors de folat i estat en folats a la població general, durant l'embaràs i efecte sobre la subfertilitat en dones
Folate receptor blocking autoantibodies (FR-AuAb), that impede transmembranal folate transport by this route, have been associated with neuronal developmental anomalies.The prevalences of FR-AuAb in the population and in pregnant women, their association with folate status, the cause of their produc...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:352 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX352 http://hdl.handle.net/10803/8570 |
| Access Level: | acceso abierto |
| Palabra clave: | 612 - Fisiologia 61 - Medicina 577 - Bioquímica. Biologia molecular. Biofísica 57 - Biologia |
| Sumario: | Folate receptor blocking autoantibodies (FR-AuAb), that impede transmembranal folate transport by this route, have been associated with neuronal developmental anomalies.The prevalences of FR-AuAb in the population and in pregnant women, their association with folate status, the cause of their production and effect on female subfertility were investigated.7.2% of the population and 6.3% of pregnant women were carriers, but folate status was not impaired. However higher cord folate status indicated the presence of a compensatory mechanism. Birth weight of carriers' offspring was 4.6 times more likely to be below the 25th percentile. The presence of FR-AuAb in the cord (7.5%) was not associated with maternal presence, cord folate status, or birth weight. High milk consumers had 2.4 times more risk of having FR-AuAb than the rest of consumers.FR-AuAb carriers at preconception were 12 times more likely to have subfertility than non-carriers. |
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