Onychomycosis associated with diabetic foot syndrome: A systematic review

Background A systematic review was conducted to investigate the prevalence of onychomycosis in patients with diabetes. The association of onychomycosis with risk factors in patients with diabetic foot syndrome was also examined. Methods The recommendations in the preferred reporting items for system...

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Autores: Navarro Pérez, David, Tardaguila García, Aroa, García Oreja, Sara, López Moral, Mateo, García-Madrid Martín De Almagro, Marta, Lázaro Martínez, José Luis
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/103274
Acceso en línea:https://hdl.handle.net/20.500.14352/103274
Access Level:acceso abierto
Palabra clave:616.718.7/.9
diabetes mellitus
diabetic foot
diabetic neuropathy
diagnosis
onychomycosis
ulcer
Podología
3299 Otras Especialidades Médicas
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repository_id_str
spelling Onychomycosis associated with diabetic foot syndrome: A systematic reviewNavarro Pérez, DavidTardaguila García, AroaGarcía Oreja, SaraLópez Moral, MateoGarcía-Madrid Martín De Almagro, MartaLázaro Martínez, José Luis616.718.7/.9diabetes mellitusdiabetic footdiabetic neuropathydiagnosisonychomycosisulcerPodología3299 Otras Especialidades MédicasBackground A systematic review was conducted to investigate the prevalence of onychomycosis in patients with diabetes. The association of onychomycosis with risk factors in patients with diabetic foot syndrome was also examined. Methods The recommendations in the preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist were applied, and the included studies were assessed using the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) method. Searches were conducted in October 2022 using PubMed (Medline) and Scopus for clinical studies, clinical trials, comparative studies, observational studies, and randomised clinical trials or controlled clinical trials addressing the prevalence and consequences of onychomycosis in patients with diabetes, diagnoses or treatments. Two authors performed the study selection and data extraction, and any discrepancies between the two reviewers were resolved through discussion with a third reviewer. Results The systematic review included ten studies that met the inclusion criteria, and these studies enrolled 5664 patients with diabetes. Among these patients, 29.18% had onychomycosis that was mainly caused by Trichophyton rubrum. A significant association was found between the occurrence of onychomycosis and the presence of diabetic neuropathy (p = .012) and elevated glycosylated haemoglobin values (p = .039). There was no significant association between onychomycosis and ulceration (p = .185). Eight studies had a grade 4 level of evidence and a grade C recommendation, and one study had a grade 1b level of evidence and a grade A recommendation. Conclusion The information described in the literature is insufficient and heterogeneous regarding the association of risk factors and ulceration in patients with diabetic foot compared with developing onychomycosis. There is also a need to implement onychomycosis diagnostic testing instead of relying only on a clinical diagnosis. Additional prospective, randomised, comparative studies are needed to increase the quality of studies in the literature.WileyUniversidad Complutense de Madrid20232023-02-1520232023-02-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/103274reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1032742026-06-02T12:44:21Z
dc.title.none.fl_str_mv Onychomycosis associated with diabetic foot syndrome: A systematic review
title Onychomycosis associated with diabetic foot syndrome: A systematic review
spellingShingle Onychomycosis associated with diabetic foot syndrome: A systematic review
Navarro Pérez, David
616.718.7/.9
diabetes mellitus
diabetic foot
diabetic neuropathy
diagnosis
onychomycosis
ulcer
Podología
3299 Otras Especialidades Médicas
title_short Onychomycosis associated with diabetic foot syndrome: A systematic review
title_full Onychomycosis associated with diabetic foot syndrome: A systematic review
title_fullStr Onychomycosis associated with diabetic foot syndrome: A systematic review
title_full_unstemmed Onychomycosis associated with diabetic foot syndrome: A systematic review
title_sort Onychomycosis associated with diabetic foot syndrome: A systematic review
dc.creator.none.fl_str_mv Navarro Pérez, David
Tardaguila García, Aroa
García Oreja, Sara
López Moral, Mateo
García-Madrid Martín De Almagro, Marta
Lázaro Martínez, José Luis
author Navarro Pérez, David
author_facet Navarro Pérez, David
Tardaguila García, Aroa
García Oreja, Sara
López Moral, Mateo
García-Madrid Martín De Almagro, Marta
Lázaro Martínez, José Luis
author_role author
author2 Tardaguila García, Aroa
García Oreja, Sara
López Moral, Mateo
García-Madrid Martín De Almagro, Marta
Lázaro Martínez, José Luis
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.718.7/.9
diabetes mellitus
diabetic foot
diabetic neuropathy
diagnosis
onychomycosis
ulcer
Podología
3299 Otras Especialidades Médicas
topic 616.718.7/.9
diabetes mellitus
diabetic foot
diabetic neuropathy
diagnosis
onychomycosis
ulcer
Podología
3299 Otras Especialidades Médicas
description Background A systematic review was conducted to investigate the prevalence of onychomycosis in patients with diabetes. The association of onychomycosis with risk factors in patients with diabetic foot syndrome was also examined. Methods The recommendations in the preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist were applied, and the included studies were assessed using the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) method. Searches were conducted in October 2022 using PubMed (Medline) and Scopus for clinical studies, clinical trials, comparative studies, observational studies, and randomised clinical trials or controlled clinical trials addressing the prevalence and consequences of onychomycosis in patients with diabetes, diagnoses or treatments. Two authors performed the study selection and data extraction, and any discrepancies between the two reviewers were resolved through discussion with a third reviewer. Results The systematic review included ten studies that met the inclusion criteria, and these studies enrolled 5664 patients with diabetes. Among these patients, 29.18% had onychomycosis that was mainly caused by Trichophyton rubrum. A significant association was found between the occurrence of onychomycosis and the presence of diabetic neuropathy (p = .012) and elevated glycosylated haemoglobin values (p = .039). There was no significant association between onychomycosis and ulceration (p = .185). Eight studies had a grade 4 level of evidence and a grade C recommendation, and one study had a grade 1b level of evidence and a grade A recommendation. Conclusion The information described in the literature is insufficient and heterogeneous regarding the association of risk factors and ulceration in patients with diabetic foot compared with developing onychomycosis. There is also a need to implement onychomycosis diagnostic testing instead of relying only on a clinical diagnosis. Additional prospective, randomised, comparative studies are needed to increase the quality of studies in the literature.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-15
2023
2023-02-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/103274
url https://hdl.handle.net/20.500.14352/103274
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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