PTSA-Catalyzed Reaction of Indoles with 2-Oxoaldehydes: Synthesis of α,α-Bis(indol-3-yl) Ketones
A convenient procedure for accessing a,a-bis(indol-3-yl) ketones from indoles and a-oxoaldehydes is described using an inexpensive and commercially available catalyst such as ptoluenesulfonic acid monohydrate. This protocol allows for the first time the synthesis of 2,2-bis(indolyl)-1-alkylethanones...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Burgos (UBU) |
| Repositorio: | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| OAI Identifier: | oai:riubu.ubu.es:10259/4529 |
| Acceso en línea: | http://hdl.handle.net/10259/4529 |
| Access Level: | acceso abierto |
| Palabra clave: | Química orgánica Chemistry, Organic |
| Sumario: | A convenient procedure for accessing a,a-bis(indol-3-yl) ketones from indoles and a-oxoaldehydes is described using an inexpensive and commercially available catalyst such as ptoluenesulfonic acid monohydrate. This protocol allows for the first time the synthesis of 2,2-bis(indolyl)-1-alkylethanones by employing aliphatic 2-oxoaldehydes, even as aqueous solutions. The high-yielded obtained ketones have been shown as useful starting materials for further synthetic transformations. |
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