Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903...

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Autores: Peñalver Argüeso, Belén, García Esquinas, Esther, Castelló, Adela, Fernández de Larrea Baz, Nerea, Castaño Vinyals, Gemma, Amiano, Pilar, Fernández Villa, Tania, Guevara, Marcela, Fernández Tardón, Guillermo, Alguacil, Juan, Obón Santacana, Mireia, Gómez Acebo, Inés, Pinto Carbó, Marina, Marcos Gragera, Rafael, Aragonés, Nuria, Aizpurua, Amaia, Martín Sánchez, Vicente, Ardanaz, Eva, Dierssen Sotos, Trinidad, Jiménez Moleón, Jose Juan, Kogevinas, Manolis, Pollán, Marina, Pérez Gómez, Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/205382
Acceso en línea:https://hdl.handle.net/2445/205382
Access Level:acceso abierto
Palabra clave:Hàbit de fumar
Càncer de mama
Smoking
Breast cancer
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spelling Smoking history and breast cancer risk by pathological subtype: MCC-Spain studyPeñalver Argüeso, BelénGarcía Esquinas, EstherCastelló, AdelaFernández de Larrea Baz, NereaCastaño Vinyals, GemmaAmiano, PilarFernández Villa, TaniaGuevara, MarcelaFernández Tardón, GuillermoAlguacil, JuanObón Santacana, MireiaGómez Acebo, InésPinto Carbó, MarinaMarcos Gragera, RafaelAragonés, NuriaAizpurua, AmaiaMartín Sánchez, VicenteArdanaz, EvaDierssen Sotos, TrinidadJiménez Moleón, Jose JuanKogevinas, ManolisPollán, MarinaPérez Gómez, BeatrizHàbit de fumarCàncer de mamaSmokingBreast cancerINTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked >= 30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking >= 10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.E.U. European Publishing2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/205382Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.18332/tid/174132Tobacco Induced Diseases, 2023, vol. 21, issue. 11, p. 1-16https://doi.org/10.18332/tid/174132cc by (c) Peñalver Argüeso, Belén et al, 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2053822026-05-27T06:46:51Z
dc.title.none.fl_str_mv Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
spellingShingle Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
Peñalver Argüeso, Belén
Hàbit de fumar
Càncer de mama
Smoking
Breast cancer
title_short Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_fullStr Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full_unstemmed Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_sort Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
dc.creator.none.fl_str_mv Peñalver Argüeso, Belén
García Esquinas, Esther
Castelló, Adela
Fernández de Larrea Baz, Nerea
Castaño Vinyals, Gemma
Amiano, Pilar
Fernández Villa, Tania
Guevara, Marcela
Fernández Tardón, Guillermo
Alguacil, Juan
Obón Santacana, Mireia
Gómez Acebo, Inés
Pinto Carbó, Marina
Marcos Gragera, Rafael
Aragonés, Nuria
Aizpurua, Amaia
Martín Sánchez, Vicente
Ardanaz, Eva
Dierssen Sotos, Trinidad
Jiménez Moleón, Jose Juan
Kogevinas, Manolis
Pollán, Marina
Pérez Gómez, Beatriz
author Peñalver Argüeso, Belén
author_facet Peñalver Argüeso, Belén
García Esquinas, Esther
Castelló, Adela
Fernández de Larrea Baz, Nerea
Castaño Vinyals, Gemma
Amiano, Pilar
Fernández Villa, Tania
Guevara, Marcela
Fernández Tardón, Guillermo
Alguacil, Juan
Obón Santacana, Mireia
Gómez Acebo, Inés
Pinto Carbó, Marina
Marcos Gragera, Rafael
Aragonés, Nuria
Aizpurua, Amaia
Martín Sánchez, Vicente
Ardanaz, Eva
Dierssen Sotos, Trinidad
Jiménez Moleón, Jose Juan
Kogevinas, Manolis
Pollán, Marina
Pérez Gómez, Beatriz
author_role author
author2 García Esquinas, Esther
Castelló, Adela
Fernández de Larrea Baz, Nerea
Castaño Vinyals, Gemma
Amiano, Pilar
Fernández Villa, Tania
Guevara, Marcela
Fernández Tardón, Guillermo
Alguacil, Juan
Obón Santacana, Mireia
Gómez Acebo, Inés
Pinto Carbó, Marina
Marcos Gragera, Rafael
Aragonés, Nuria
Aizpurua, Amaia
Martín Sánchez, Vicente
Ardanaz, Eva
Dierssen Sotos, Trinidad
Jiménez Moleón, Jose Juan
Kogevinas, Manolis
Pollán, Marina
Pérez Gómez, Beatriz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hàbit de fumar
Càncer de mama
Smoking
Breast cancer
topic Hàbit de fumar
Càncer de mama
Smoking
Breast cancer
description INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked >= 30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking >= 10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk.CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/205382
url https://hdl.handle.net/2445/205382
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.18332/tid/174132
Tobacco Induced Diseases, 2023, vol. 21, issue. 11, p. 1-16
https://doi.org/10.18332/tid/174132
dc.rights.none.fl_str_mv cc by (c) Peñalver Argüeso, Belén et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Peñalver Argüeso, Belén et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv E.U. European Publishing
publisher.none.fl_str_mv E.U. European Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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