The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
Background: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives: To ev...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:272151 |
| Acceso en línea: | https://ddd.uab.cat/record/272151 https://dx.doi.org/urn:doi:10.1111/ppe.12682 |
| Access Level: | acceso abierto |
| Palabra clave: | Endocrinology Gynaecology Insulin Lipid metabolism Obesity |
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The importance of maternal insulin resistance throughout pregnancy on neonatal adiposityLima, Rodrigo|||0000-0002-7778-2616Desoye, Gernot|||0000-0002-5715-3230Simmons, David|||0000-0003-0560-0761Devlieger, Roland|||0000-0001-7837-4684Galjaard, Sander|||0000-0002-4254-6664Corcoy i Pla, Rosa|||0000-0001-5055-6814Adelantado, Juan M.|||0000-0001-6399-4856Dunne, Fidelma|||0000-0003-3682-9403Harreiter, Jürgen|||0000-0003-2508-9403Kautzky-Willer, Alexandra|||0000-0002-3520-4105Damm, Peter|||0000-0002-2067-5246Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863Jensen, Dorte M.|||0000-0002-3298-9824Andersen, Lise-Lotte|||0000-0003-2997-2228Tanvig, MetteLapolla, AnnunziataDalfra, Maria Grazia|||0000-0002-3011-0521Bertolotto, Alessandra|||0000-0003-1578-5421Manta, UrszulaWender-Ozegowska, Ewa|||0000-0002-5492-8651Zawiejska, Agnieszka|||0000-0002-3616-6550Hill, David J.|||0000-0002-2490-5678Snoek, Frank J.Jelsma, Judith G. M.|||0000-0001-7943-9160Van Poppel, Mireille|||0000-0001-5694-4324EndocrinologyGynaecologyInsulinLipid metabolismObesityBackground: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results: Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20.3 mm, 95% CI 19.7, 21.0 vs 21.5 mm, 95% CI 20.8, 22.2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (β = 0.35 mm, 95% CI 0.01, 0.70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (β = 0.26 mm, 95% CI 0.08, 0.44). Conclusions: The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/272151https://dx.doi.org/urn:doi:10.1111/ppe.12682reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 242187open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2721512026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| title |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| spellingShingle |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity Lima, Rodrigo|||0000-0002-7778-2616 Endocrinology Gynaecology Insulin Lipid metabolism Obesity |
| title_short |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| title_full |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| title_fullStr |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| title_full_unstemmed |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| title_sort |
The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity |
| dc.creator.none.fl_str_mv |
Lima, Rodrigo|||0000-0002-7778-2616 Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Manta, Urszula Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, David J.|||0000-0002-2490-5678 Snoek, Frank J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author |
Lima, Rodrigo|||0000-0002-7778-2616 |
| author_facet |
Lima, Rodrigo|||0000-0002-7778-2616 Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Manta, Urszula Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, David J.|||0000-0002-2490-5678 Snoek, Frank J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author_role |
author |
| author2 |
Desoye, Gernot|||0000-0002-5715-3230 Simmons, David|||0000-0003-0560-0761 Devlieger, Roland|||0000-0001-7837-4684 Galjaard, Sander|||0000-0002-4254-6664 Corcoy i Pla, Rosa|||0000-0001-5055-6814 Adelantado, Juan M.|||0000-0001-6399-4856 Dunne, Fidelma|||0000-0003-3682-9403 Harreiter, Jürgen|||0000-0003-2508-9403 Kautzky-Willer, Alexandra|||0000-0002-3520-4105 Damm, Peter|||0000-0002-2067-5246 Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863 Jensen, Dorte M.|||0000-0002-3298-9824 Andersen, Lise-Lotte|||0000-0003-2997-2228 Tanvig, Mette Lapolla, Annunziata Dalfra, Maria Grazia|||0000-0002-3011-0521 Bertolotto, Alessandra|||0000-0003-1578-5421 Manta, Urszula Wender-Ozegowska, Ewa|||0000-0002-5492-8651 Zawiejska, Agnieszka|||0000-0002-3616-6550 Hill, David J.|||0000-0002-2490-5678 Snoek, Frank J. Jelsma, Judith G. M.|||0000-0001-7943-9160 Van Poppel, Mireille|||0000-0001-5694-4324 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Endocrinology Gynaecology Insulin Lipid metabolism Obesity |
| topic |
Endocrinology Gynaecology Insulin Lipid metabolism Obesity |
| description |
Background: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results: Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20.3 mm, 95% CI 19.7, 21.0 vs 21.5 mm, 95% CI 20.8, 22.2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (β = 0.35 mm, 95% CI 0.01, 0.70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (β = 0.26 mm, 95% CI 0.08, 0.44). Conclusions: The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/272151 https://dx.doi.org/urn:doi:10.1111/ppe.12682 |
| url |
https://ddd.uab.cat/record/272151 https://dx.doi.org/urn:doi:10.1111/ppe.12682 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 242187 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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