Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy
Acute ischemic stroke; Blood-brain barrier; Cerebrolysin
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::57227bff7f44f2720b52c9baa644ec3a |
| Acceso en línea: | http://hdl.handle.net/11351/14700 https://hdl.handle.net/11351/14700 |
| Access Level: | acceso abierto |
| Palabra clave: | Malalties cerebrovasculars - Tractament Neurofarmacologia CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents Other subheadings::Other subheadings::/therapeutic use DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke Other subheadings::Other subheadings::Other subheadings::/drug therapy COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
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Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapyStaszewski, JacekZeiler, StevenMichalak, SlawomirElbassiouny, AhmedGONGORA-RIVERA, FERNANDORibo, MarcMalalties cerebrovasculars - TractamentNeurofarmacologiaCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective AgentsOther subheadings::Other subheadings::/therapeutic useDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::StrokeOther subheadings::Other subheadings::Other subheadings::/drug therapyCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectoresOtros calificadores::Otros calificadores::/uso terapéuticoENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascularOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaAcute ischemic stroke; Blood-brain barrier; CerebrolysinAccident cerebrovascular isquèmic agut; Barrera hematoencefàlica; CerebrolisinaAccidente cerebrovascular isquémico agudo; Barrera hematoencefálica; CerebrolisinaThis article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy, such as Cerebrolysin, is likely to further improve patient outcomes. Beyond its established neurorecovery benefits, recent data indicate that Cerebrolysin also offers protection to the neurovascular unit and the blood-brain barrier. This paper introduces the CErebrolysin in RECanalization And Perfusion (CERECAP) program, a collaborative initiative of independent academic investigations exploring the favorable trends of Cerebrolysin in reperfusion. The CERECAP program has generated compelling data demonstrating Cerebrolysin's alignment with current AIS reperfusion therapy concepts, particularly its role in early intervention targeting multiple pathways. We review these studies and discuss the critical need to clearly define the patient population that benefit most from adjunctive Cerebrolysin therapy in AIS.ElsevierInstitut Català de la Salut[Ribó M] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Staszewski J] Clinic of Neurology, Military Institute of Medicine – National Research Institute, Warsaw, Poland. [Zeiler SR] Johns Hopkins University, Baltimore, USA. [Michalak S] University Clinical Hospital in Poznań, Poznań, Poland. [El Bassiouny A] Ain Shams University, Ramsis Street Square, El Weili, Cairo, Egypt. [Gongora-Rivera F] Department of Neurology CITEN, University Hospital "Dr. José Eleuterio González", Monterrey, MexicoVall d'Hebron Barcelona Hospital Campus2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14700https://hdl.handle.net/11351/14700Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Stroke and Cerebrovascular Diseases;35(1)https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108515Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::57227bff7f44f2720b52c9baa644ec3a2026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| title |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| spellingShingle |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy Staszewski, Jacek Malalties cerebrovasculars - Tractament Neurofarmacologia CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents Other subheadings::Other subheadings::/therapeutic use DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke Other subheadings::Other subheadings::Other subheadings::/drug therapy COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| title_short |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| title_full |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| title_fullStr |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| title_full_unstemmed |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| title_sort |
Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy |
| dc.creator.none.fl_str_mv |
Staszewski, Jacek Zeiler, Steven Michalak, Slawomir Elbassiouny, Ahmed GONGORA-RIVERA, FERNANDO Ribo, Marc |
| author |
Staszewski, Jacek |
| author_facet |
Staszewski, Jacek Zeiler, Steven Michalak, Slawomir Elbassiouny, Ahmed GONGORA-RIVERA, FERNANDO Ribo, Marc |
| author_role |
author |
| author2 |
Zeiler, Steven Michalak, Slawomir Elbassiouny, Ahmed GONGORA-RIVERA, FERNANDO Ribo, Marc |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Ribó M] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Staszewski J] Clinic of Neurology, Military Institute of Medicine – National Research Institute, Warsaw, Poland. [Zeiler SR] Johns Hopkins University, Baltimore, USA. [Michalak S] University Clinical Hospital in Poznań, Poznań, Poland. [El Bassiouny A] Ain Shams University, Ramsis Street Square, El Weili, Cairo, Egypt. [Gongora-Rivera F] Department of Neurology CITEN, University Hospital "Dr. José Eleuterio González", Monterrey, Mexico Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Malalties cerebrovasculars - Tractament Neurofarmacologia CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents Other subheadings::Other subheadings::/therapeutic use DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke Other subheadings::Other subheadings::Other subheadings::/drug therapy COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| topic |
Malalties cerebrovasculars - Tractament Neurofarmacologia CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents Other subheadings::Other subheadings::/therapeutic use DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke Other subheadings::Other subheadings::Other subheadings::/drug therapy COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| description |
Acute ischemic stroke; Blood-brain barrier; Cerebrolysin |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2026 2026 2026 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/14700 https://hdl.handle.net/11351/14700 |
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http://hdl.handle.net/11351/14700 https://hdl.handle.net/11351/14700 |
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Inglés |
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Inglés |
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Journal of Stroke and Cerebrovascular Diseases;35(1) https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108515 |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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