The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature
The mutation of the plant homeodomain finger protein 6 gene (PHF6MUT) in patients with myeloid neoplasms (MNs) is rare and appears to play a role in prognosis, though this is still under debate. We conducted a retrospective analysis of a cohort of 313 patients diagnosed with MNs. We also performed a...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/752240 |
| Acceso en línea: | https://hdl.handle.net/10486/752240 https://dx.doi.org/10.1007/s00277-026-06766-y |
| Access Level: | acceso abierto |
| Palabra clave: | Acute myeloid leukemia Myelodisplastic syndrome Myelodysplastic-myeloproliferative diseases Myeloproliferative disorders PHF6 Medicina |
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The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literatureSuárez Merchán, Edwin UrielAtencia, Carlos J.Torres-Saavedra, Fabio A.Conejero, NazarethSalgado, Rocío N.Atance-Pararisas, MireiaPerlado Marina, SaraSoto, CarlosAlonso Domínguez, Juan ManuelArquero-Portero, TeresaMata, RaquelJiménez, ElenaLópez Lorenzo, José LuisArriero, Álvaro VSerrano-López, JuanaRodríguez Pinilla, Socorro MaríaLlamas Sillero, PilarAcute myeloid leukemiaMyelodisplastic syndromeMyelodysplastic-myeloproliferative diseasesMyeloproliferative disordersPHF6MedicinaThe mutation of the plant homeodomain finger protein 6 gene (PHF6MUT) in patients with myeloid neoplasms (MNs) is rare and appears to play a role in prognosis, though this is still under debate. We conducted a retrospective analysis of a cohort of 313 patients diagnosed with MNs. We also performed a systematic review (SR) of the literature to evaluate the prognostic role of PHF6 gene status in MNs. We identified 15 patients with PHF6MUT. In the multivariate analysis, PHF6MUT was associated with higher mortality compared to PHF6wild − type (hazard ratio [HR]=1.02; 95% confidence interval [CI], 1.00–1.05; P=0.075), with no apparent impact from other co-mutations. In the multilevel logistic model by MN subtype, the presence of PHF6MUT (independent of variant allele frequency>20%) was shown to have a positive coefficient (adverse prognosis) in acute myeloid leukemia; in the remainder of MNs, the effect was not significant. PHF6MUT had a marginal and significant effect compared to PHF6wild − type cases (HR=1.02; 95% CI, 1.00-1.05; P=0.039). There were no significant differences in time to blast transformation or time to next treatment depending on PHF6 gene status. According to the results of most studies published to date (SR), PHF6MUT has a prognostic role in MNs; our results are consistent in terms of clinical outcomes, but these marginal effects should be interpreted with caution in the context of existing prognostic models given the limitations of the small sample sizeSpringerDepartamento de MedicinaFacultad de Medicina20262026-02-04research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/752240https://dx.doi.org/10.1007/s00277-026-06766-yreponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7522402026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| title |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| spellingShingle |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature Suárez Merchán, Edwin Uriel Acute myeloid leukemia Myelodisplastic syndrome Myelodysplastic-myeloproliferative diseases Myeloproliferative disorders PHF6 Medicina |
| title_short |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| title_full |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| title_fullStr |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| title_full_unstemmed |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| title_sort |
The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature |
| dc.creator.none.fl_str_mv |
Suárez Merchán, Edwin Uriel Atencia, Carlos J. Torres-Saavedra, Fabio A. Conejero, Nazareth Salgado, Rocío N. Atance-Pararisas, Mireia Perlado Marina, Sara Soto, Carlos Alonso Domínguez, Juan Manuel Arquero-Portero, Teresa Mata, Raquel Jiménez, Elena López Lorenzo, José Luis Arriero, Álvaro V Serrano-López, Juana Rodríguez Pinilla, Socorro María Llamas Sillero, Pilar |
| author |
Suárez Merchán, Edwin Uriel |
| author_facet |
Suárez Merchán, Edwin Uriel Atencia, Carlos J. Torres-Saavedra, Fabio A. Conejero, Nazareth Salgado, Rocío N. Atance-Pararisas, Mireia Perlado Marina, Sara Soto, Carlos Alonso Domínguez, Juan Manuel Arquero-Portero, Teresa Mata, Raquel Jiménez, Elena López Lorenzo, José Luis Arriero, Álvaro V Serrano-López, Juana Rodríguez Pinilla, Socorro María Llamas Sillero, Pilar |
| author_role |
author |
| author2 |
Atencia, Carlos J. Torres-Saavedra, Fabio A. Conejero, Nazareth Salgado, Rocío N. Atance-Pararisas, Mireia Perlado Marina, Sara Soto, Carlos Alonso Domínguez, Juan Manuel Arquero-Portero, Teresa Mata, Raquel Jiménez, Elena López Lorenzo, José Luis Arriero, Álvaro V Serrano-López, Juana Rodríguez Pinilla, Socorro María Llamas Sillero, Pilar |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
Acute myeloid leukemia Myelodisplastic syndrome Myelodysplastic-myeloproliferative diseases Myeloproliferative disorders PHF6 Medicina |
| topic |
Acute myeloid leukemia Myelodisplastic syndrome Myelodysplastic-myeloproliferative diseases Myeloproliferative disorders PHF6 Medicina |
| description |
The mutation of the plant homeodomain finger protein 6 gene (PHF6MUT) in patients with myeloid neoplasms (MNs) is rare and appears to play a role in prognosis, though this is still under debate. We conducted a retrospective analysis of a cohort of 313 patients diagnosed with MNs. We also performed a systematic review (SR) of the literature to evaluate the prognostic role of PHF6 gene status in MNs. We identified 15 patients with PHF6MUT. In the multivariate analysis, PHF6MUT was associated with higher mortality compared to PHF6wild − type (hazard ratio [HR]=1.02; 95% confidence interval [CI], 1.00–1.05; P=0.075), with no apparent impact from other co-mutations. In the multilevel logistic model by MN subtype, the presence of PHF6MUT (independent of variant allele frequency>20%) was shown to have a positive coefficient (adverse prognosis) in acute myeloid leukemia; in the remainder of MNs, the effect was not significant. PHF6MUT had a marginal and significant effect compared to PHF6wild − type cases (HR=1.02; 95% CI, 1.00-1.05; P=0.039). There were no significant differences in time to blast transformation or time to next treatment depending on PHF6 gene status. According to the results of most studies published to date (SR), PHF6MUT has a prognostic role in MNs; our results are consistent in terms of clinical outcomes, but these marginal effects should be interpreted with caution in the context of existing prognostic models given the limitations of the small sample size |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 2026-02-04 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10486/752240 https://dx.doi.org/10.1007/s00277-026-06766-y |
| url |
https://hdl.handle.net/10486/752240 https://dx.doi.org/10.1007/s00277-026-06766-y |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Springer |
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Springer |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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