Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

12 páginas

Detalles Bibliográficos
Autores: Nikoletopoulou, Vassiliki, Lickert, H., Frade López, José María, Rencurel, Chantal, Giallonardo, P., Zhang, Lixing, Barde, Yves Alain
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/27437
Acceso en línea:http://hdl.handle.net/10261/27437
Access Level:acceso abierto
Palabra clave:Neuroscience
Stem cells
Developmental biology
Molecular biology
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spelling Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does notNikoletopoulou, VassilikiLickert, H.Frade López, José MaríaRencurel, ChantalGiallonardo, P.Zhang, LixingBarde, Yves AlainNeuroscienceStem cellsDevelopmental biologyMolecular biology12 páginasNeurons of the peripheral nervous system have long been known to require survival factors to prevent their death during development. But why they selectively become dependent on secretory molecules has remained a mystery, as is the observation that in the central nervous system, most neurons do not show this dependency. Using engineered embryonic stem cells, we show here that the neurotrophin receptors TrkA and TrkC (tropomyosin receptor kinase A and C, also known as Ntrk1 and Ntrk3, respectively) instruct developing neurons to die, both in vitro and in vivo. By contrast, TrkB (also known as Ntrk2), a closely related receptor primarily expressed in the central nervous system, does not. These results indicate that TrkA and TrkC behave as dependence receptors, explaining why developing sympathetic and sensory neurons become trophic-factor-dependent for survival. We suggest that the expansion of the Trk gene family that accompanied the segregation of the peripheral from the central nervous system generated a novel mechanism of cell number controlH.L. is supported by an Emmy-Nother fellowship of the DFG.Peer reviewedNature Publishing Group201020102010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501146015 bytesapplication/pdfhttp://hdl.handle.net/10261/27437reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1038/nature09336info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/274372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
title Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
spellingShingle Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
Nikoletopoulou, Vassiliki
Neuroscience
Stem cells
Developmental biology
Molecular biology
title_short Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
title_full Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
title_fullStr Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
title_full_unstemmed Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
title_sort Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
dc.creator.none.fl_str_mv Nikoletopoulou, Vassiliki
Lickert, H.
Frade López, José María
Rencurel, Chantal
Giallonardo, P.
Zhang, Lixing
Barde, Yves Alain
author Nikoletopoulou, Vassiliki
author_facet Nikoletopoulou, Vassiliki
Lickert, H.
Frade López, José María
Rencurel, Chantal
Giallonardo, P.
Zhang, Lixing
Barde, Yves Alain
author_role author
author2 Lickert, H.
Frade López, José María
Rencurel, Chantal
Giallonardo, P.
Zhang, Lixing
Barde, Yves Alain
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuroscience
Stem cells
Developmental biology
Molecular biology
topic Neuroscience
Stem cells
Developmental biology
Molecular biology
description 12 páginas
publishDate 2010
dc.date.none.fl_str_mv 2010
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/27437
url http://hdl.handle.net/10261/27437
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1038/nature09336
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 146015 bytes
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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