Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores

Lecumberri-Villamediana, R. (Ramón)|||/items/d804c113-76a8-47fb-85ad-0f01acbe605a; Jiménez, L. (Laura)|||/items/7071fdc7-12bd-4f79-b998-c54f0618b22f; Ruiz-Artacho, P.C. (Pedro Celso)|||/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087; Nieto, J.A. (José Antonio)|||/items/86b9cf34-8abb-4e53-ac9f-00d4df19eeba; Ruiz-Giménez, N. (Nuria)|||/items/f552baf1-15a9-485a-ae55-6b6d92ac725b; Visonà, A. (Adriana)|||/items/077bba31-16c7-45ae-a488-383c971dd292; Skride, A. (Andris)|||/items/c01f6245-26c4-4792-944c-0f0e1833576f; Moustafa, F. (Fares)|||/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5; Trujillo-Santos, J. (Javier)|||/items/9dc5c758-9433-4009-98c8-584348188760; Monreal, M. (Manuel)|||/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031

Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores

The performance of validated bleeding risk scores in patients with venous thromboembolism (VTE) could be different depending on the time after index event or the site of bleeding. In this study we compared the "classic" Registro Informatizado de Enfermedad TromboEmbólica (RIETE) score and...

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Detalles Bibliográficos
Autores:	Lecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605a, Jiménez, L. (Laura)\|\|\|/items/7071fdc7-12bd-4f79-b998-c54f0618b22f, Ruiz-Artacho, P.C. (Pedro Celso)\|\|\|/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087, Nieto, J.A. (José Antonio)\|\|\|/items/86b9cf34-8abb-4e53-ac9f-00d4df19eeba, Ruiz-Giménez, N. (Nuria)\|\|\|/items/f552baf1-15a9-485a-ae55-6b6d92ac725b, Visonà, A. (Adriana)\|\|\|/items/077bba31-16c7-45ae-a488-383c971dd292, Skride, A. (Andris)\|\|\|/items/c01f6245-26c4-4792-944c-0f0e1833576f, Moustafa, F. (Fares)\|\|\|/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5, Trujillo-Santos, J. (Javier)\|\|\|/items/9dc5c758-9433-4009-98c8-584348188760, Monreal, M. (Manuel)\|\|\|/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/115894
Acceso en línea:	https://hdl.handle.net/10171/115894
Access Level:	acceso abierto
Palabra clave:	Anticoagulation Bleeding Hemorrhage Score Venous thromboembolism

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spelling	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED ScoresLecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605aJiménez, L. (Laura)\|\|\|/items/7071fdc7-12bd-4f79-b998-c54f0618b22fRuiz-Artacho, P.C. (Pedro Celso)\|\|\|/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087Nieto, J.A. (José Antonio)\|\|\|/items/86b9cf34-8abb-4e53-ac9f-00d4df19eebaRuiz-Giménez, N. (Nuria)\|\|\|/items/f552baf1-15a9-485a-ae55-6b6d92ac725bVisonà, A. (Adriana)\|\|\|/items/077bba31-16c7-45ae-a488-383c971dd292Skride, A. (Andris)\|\|\|/items/c01f6245-26c4-4792-944c-0f0e1833576fMoustafa, F. (Fares)\|\|\|/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5Trujillo-Santos, J. (Javier)\|\|\|/items/9dc5c758-9433-4009-98c8-584348188760Monreal, M. (Manuel)\|\|\|/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031AnticoagulationBleedingHemorrhageScoreVenous thromboembolismThe performance of validated bleeding risk scores in patients with venous thromboembolism (VTE) could be different depending on the time after index event or the site of bleeding. In this study we compared the "classic" Registro Informatizado de Enfermedad TromboEmbólica (RIETE) score and the more recently developed VTE-BLEED score for the prediction of major bleeding in patients under anticoagulant therapy in different time intervals after VTE diagnosis. Out of 82,239 patients with acute VTE, the proportion of high-risk patients according to the RIETE and VTE-BLEED scores was 7.1 and 62.3%, respectively. The performance of both scores across the different study periods (first 30 days after VTE diagnosis, days 31-90, days 91-180, and days 181-360) was similar, with areas under the receiving operating characteristics (ROC) curve (AUC) ranging between 0.69 and 0.72. However, the positive predictive values were low, ranging between 0.6 and 3.9 (better for early major bleeding than for later periods). A sensitivity analysis limited to patients with unprovoked VTE showed comparable results. Both scores showed a trend toward a better prediction of extracranial than intracranial major bleeding, the RIETE score resulting more useful for early extracranial bleeding and the VTE-BLEED for late intracranial hemorrhages. Our study reveals that the usefulness of available bleeding scores may vary depending on the characteristics of the patient population and the time frame evaluated. Dynamic scores could be more useful for this purpose.Thieme GroupDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/115894reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1158942026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
title	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
spellingShingle	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores Lecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605a Anticoagulation Bleeding Hemorrhage Score Venous thromboembolism
title_short	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
title_full	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
title_fullStr	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
title_full_unstemmed	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
title_sort	Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores
dc.creator.none.fl_str_mv	Lecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605a Jiménez, L. (Laura)\|\|\|/items/7071fdc7-12bd-4f79-b998-c54f0618b22f Ruiz-Artacho, P.C. (Pedro Celso)\|\|\|/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087 Nieto, J.A. (José Antonio)\|\|\|/items/86b9cf34-8abb-4e53-ac9f-00d4df19eeba Ruiz-Giménez, N. (Nuria)\|\|\|/items/f552baf1-15a9-485a-ae55-6b6d92ac725b Visonà, A. (Adriana)\|\|\|/items/077bba31-16c7-45ae-a488-383c971dd292 Skride, A. (Andris)\|\|\|/items/c01f6245-26c4-4792-944c-0f0e1833576f Moustafa, F. (Fares)\|\|\|/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5 Trujillo-Santos, J. (Javier)\|\|\|/items/9dc5c758-9433-4009-98c8-584348188760 Monreal, M. (Manuel)\|\|\|/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031
author	Lecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605a
author_facet	Lecumberri-Villamediana, R. (Ramón)\|\|\|/items/d804c113-76a8-47fb-85ad-0f01acbe605a Jiménez, L. (Laura)\|\|\|/items/7071fdc7-12bd-4f79-b998-c54f0618b22f Ruiz-Artacho, P.C. (Pedro Celso)\|\|\|/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087 Nieto, J.A. (José Antonio)\|\|\|/items/86b9cf34-8abb-4e53-ac9f-00d4df19eeba Ruiz-Giménez, N. (Nuria)\|\|\|/items/f552baf1-15a9-485a-ae55-6b6d92ac725b Visonà, A. (Adriana)\|\|\|/items/077bba31-16c7-45ae-a488-383c971dd292 Skride, A. (Andris)\|\|\|/items/c01f6245-26c4-4792-944c-0f0e1833576f Moustafa, F. (Fares)\|\|\|/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5 Trujillo-Santos, J. (Javier)\|\|\|/items/9dc5c758-9433-4009-98c8-584348188760 Monreal, M. (Manuel)\|\|\|/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031
author_role	author
author2	Jiménez, L. (Laura)\|\|\|/items/7071fdc7-12bd-4f79-b998-c54f0618b22f Ruiz-Artacho, P.C. (Pedro Celso)\|\|\|/items/cdfaa5d7-8863-4e9a-b93a-d7e78096c087 Nieto, J.A. (José Antonio)\|\|\|/items/86b9cf34-8abb-4e53-ac9f-00d4df19eeba Ruiz-Giménez, N. (Nuria)\|\|\|/items/f552baf1-15a9-485a-ae55-6b6d92ac725b Visonà, A. (Adriana)\|\|\|/items/077bba31-16c7-45ae-a488-383c971dd292 Skride, A. (Andris)\|\|\|/items/c01f6245-26c4-4792-944c-0f0e1833576f Moustafa, F. (Fares)\|\|\|/items/1af9a0c2-3abe-4369-968c-ce9c164a19a5 Trujillo-Santos, J. (Javier)\|\|\|/items/9dc5c758-9433-4009-98c8-584348188760 Monreal, M. (Manuel)\|\|\|/items/c81a51a7-2e8d-4ae5-a9b1-e1b8b6d72031
author2_role	author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Anticoagulation Bleeding Hemorrhage Score Venous thromboembolism
topic	Anticoagulation Bleeding Hemorrhage Score Venous thromboembolism
description	The performance of validated bleeding risk scores in patients with venous thromboembolism (VTE) could be different depending on the time after index event or the site of bleeding. In this study we compared the "classic" Registro Informatizado de Enfermedad TromboEmbólica (RIETE) score and the more recently developed VTE-BLEED score for the prediction of major bleeding in patients under anticoagulant therapy in different time intervals after VTE diagnosis. Out of 82,239 patients with acute VTE, the proportion of high-risk patients according to the RIETE and VTE-BLEED scores was 7.1 and 62.3%, respectively. The performance of both scores across the different study periods (first 30 days after VTE diagnosis, days 31-90, days 91-180, and days 181-360) was similar, with areas under the receiving operating characteristics (ROC) curve (AUC) ranging between 0.69 and 0.72. However, the positive predictive values were low, ranging between 0.6 and 3.9 (better for early major bleeding than for later periods). A sensitivity analysis limited to patients with unprovoked VTE showed comparable results. Both scores showed a trend toward a better prediction of extracranial than intracranial major bleeding, the RIETE score resulting more useful for early extracranial bleeding and the VTE-BLEED for late intracranial hemorrhages. Our study reveals that the usefulness of available bleeding scores may vary depending on the characteristics of the patient population and the time frame evaluated. Dynamic scores could be more useful for this purpose.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/115894
url	https://hdl.handle.net/10171/115894
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Thieme Group
publisher.none.fl_str_mv	Thieme Group
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Prediction of major bleeding in anticoagulated patients for venous thromboembolism: Comparison of the RIETE and the VTE-BLEED Scores

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