Pharmacological strategies for targeting BAT thermogenesis

Modern imaging techniques have confirmed the presence of thermogenically active brown adipose tissue (BAT) in adult humans, leading to suggestions that it could be stimulated to treat obesity and its associated morbidities. The mechanisms regulating thermogenesis in BAT are better understood than ev...

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Detalles Bibliográficos
Autores: Whittle, Andrew J., Relat Pardo, Joana, Vidal-Puig, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/178887
Acceso en línea:https://hdl.handle.net/2445/178887
Access Level:acceso abierto
Palabra clave:Metabolisme
Teixit adipós
Obesitat
Metabolism
Adipose tissues
Obesity
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spelling Pharmacological strategies for targeting BAT thermogenesisWhittle, Andrew J.Relat Pardo, JoanaVidal-Puig, AntonioMetabolismeTeixit adipósObesitatMetabolismAdipose tissuesObesityModern imaging techniques have confirmed the presence of thermogenically active brown adipose tissue (BAT) in adult humans, leading to suggestions that it could be stimulated to treat obesity and its associated morbidities. The mechanisms regulating thermogenesis in BAT are better understood than ever before, with new hypotheses for increasing the amount of brown fat or its activity being put forward on a weekly basis. The challenge now is to identify safe ways to manipulate specific aspects of the physiological regulation of thermogenesis, in a manner that will be bioenergetically effective. This review outlines the nature of these regulatory mechanisms both terms of their cellular specificity and likely effectiveness given the physiological paradigms in which thermogenesis is activated. Similarly, their potential for being targeted by new or existing drugs is discussed, drawing on the known mechanisms of action of various pharmacological agents and some likely limitations that should be consideredElsevier2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/178887Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.tips.2013.04.004Trends in Pharmacological Sciences, 2013, vol. 34, num. 6, p. 347-355https://doi.org/10.1016/j.tips.2013.04.004cc-by-nc-nd (c) Elsevier, 2013https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1788872026-05-27T06:46:51Z
dc.title.none.fl_str_mv Pharmacological strategies for targeting BAT thermogenesis
title Pharmacological strategies for targeting BAT thermogenesis
spellingShingle Pharmacological strategies for targeting BAT thermogenesis
Whittle, Andrew J.
Metabolisme
Teixit adipós
Obesitat
Metabolism
Adipose tissues
Obesity
title_short Pharmacological strategies for targeting BAT thermogenesis
title_full Pharmacological strategies for targeting BAT thermogenesis
title_fullStr Pharmacological strategies for targeting BAT thermogenesis
title_full_unstemmed Pharmacological strategies for targeting BAT thermogenesis
title_sort Pharmacological strategies for targeting BAT thermogenesis
dc.creator.none.fl_str_mv Whittle, Andrew J.
Relat Pardo, Joana
Vidal-Puig, Antonio
author Whittle, Andrew J.
author_facet Whittle, Andrew J.
Relat Pardo, Joana
Vidal-Puig, Antonio
author_role author
author2 Relat Pardo, Joana
Vidal-Puig, Antonio
author2_role author
author
dc.subject.none.fl_str_mv Metabolisme
Teixit adipós
Obesitat
Metabolism
Adipose tissues
Obesity
topic Metabolisme
Teixit adipós
Obesitat
Metabolism
Adipose tissues
Obesity
description Modern imaging techniques have confirmed the presence of thermogenically active brown adipose tissue (BAT) in adult humans, leading to suggestions that it could be stimulated to treat obesity and its associated morbidities. The mechanisms regulating thermogenesis in BAT are better understood than ever before, with new hypotheses for increasing the amount of brown fat or its activity being put forward on a weekly basis. The challenge now is to identify safe ways to manipulate specific aspects of the physiological regulation of thermogenesis, in a manner that will be bioenergetically effective. This review outlines the nature of these regulatory mechanisms both terms of their cellular specificity and likely effectiveness given the physiological paradigms in which thermogenesis is activated. Similarly, their potential for being targeted by new or existing drugs is discussed, drawing on the known mechanisms of action of various pharmacological agents and some likely limitations that should be considered
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178887
url https://hdl.handle.net/2445/178887
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.tips.2013.04.004
Trends in Pharmacological Sciences, 2013, vol. 34, num. 6, p. 347-355
https://doi.org/10.1016/j.tips.2013.04.004
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2013
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2013
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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