Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer

Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a...

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Detalles Bibliográficos
Autores: Navarro Brugal, Gemma, Carriba Domínguez, Paulina, Gandía, Jorge, Ciruela Alférez, Francisco, Casadó, Vicent, Cortés Tejedor, Antonio, Mallol Montero, Josefa, Canela Campos, Enric I. (Enric Isidre), 1949-, Lluís i Biset, Carme, Franco Fernández, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/122431
Acceso en línea:https://hdl.handle.net/2445/122431
Access Level:acceso abierto
Palabra clave:Adenosina
Proteïnes
Receptors cel·lulars
Adenosine
Proteins
Cell receptors
Descripción
Sumario:Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.

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