Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction

Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of...

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Authors: Aguiar Fernández, Pablo, Pino, F, Silva Rodríguez, Jesús, Pavía, J, Ros, D, Ruibal Morell, Alvaro, El Bitar, Z
Format: article
Publication Date:2014
Country:España
Institution:Servizo Galego de Saúde (SERGAS)
Repository:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/4474
Online Access:http://hdl.handle.net/20.500.11940/4474
Access Level:Open access
Keyword:Algorithms
Computer Simulation
Monte Carlo Method
Tomography, Emission-Computed, Single-Photon
Algoritmos
Simulación por Computador
Método de Montecarlo
Tomografía Computarizada de Emisión de Fotón Único
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oai_identifier_str oai:runa.sergas.gal:20.500.11940/4474
network_acronym_str ES
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spelling Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstructionAguiar Fernández, PabloPino, FSilva Rodríguez, JesúsPavía, JRos, DRuibal Morell, AlvaroEl Bitar, ZAlgorithmsComputer SimulationMonte Carlo MethodTomography, Emission-Computed, Single-PhotonAlgoritmosSimulación por ComputadorMétodo de MontecarloTomografía Computarizada de Emisión de Fotón ÚnicoPurpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the projection noise than MC-SRM. Conclusions: The authors' findings show that both approaches provide good solutions to the problem of calculating the SRM in pinhole SPECT reconstruction. The AE-SRM was faster to create and handle the projection noise better than MC-SRM. Nevertheless, the AE-SRM required a tedious experimental characterization of the intrinsic detector response. Creation of the MC-SRM required longer computation time and handled the projection noise worse than the AE-SRM.Nevertheless, the MC-SRM inherently incorporates extensive modeling of the system and therefore experimental characterization was not required.2014info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.11940/4474reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/44742026-06-12T08:40:47Z
dc.title.none.fl_str_mv Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
title Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
spellingShingle Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
Aguiar Fernández, Pablo
Algorithms
Computer Simulation
Monte Carlo Method
Tomography, Emission-Computed, Single-Photon
Algoritmos
Simulación por Computador
Método de Montecarlo
Tomografía Computarizada de Emisión de Fotón Único
title_short Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
title_full Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
title_fullStr Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
title_full_unstemmed Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
title_sort Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
dc.creator.none.fl_str_mv Aguiar Fernández, Pablo
Pino, F
Silva Rodríguez, Jesús
Pavía, J
Ros, D
Ruibal Morell, Alvaro
El Bitar, Z
author Aguiar Fernández, Pablo
author_facet Aguiar Fernández, Pablo
Pino, F
Silva Rodríguez, Jesús
Pavía, J
Ros, D
Ruibal Morell, Alvaro
El Bitar, Z
author_role author
author2 Pino, F
Silva Rodríguez, Jesús
Pavía, J
Ros, D
Ruibal Morell, Alvaro
El Bitar, Z
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Algorithms
Computer Simulation
Monte Carlo Method
Tomography, Emission-Computed, Single-Photon
Algoritmos
Simulación por Computador
Método de Montecarlo
Tomografía Computarizada de Emisión de Fotón Único
topic Algorithms
Computer Simulation
Monte Carlo Method
Tomography, Emission-Computed, Single-Photon
Algoritmos
Simulación por Computador
Método de Montecarlo
Tomografía Computarizada de Emisión de Fotón Único
description Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the projection noise than MC-SRM. Conclusions: The authors' findings show that both approaches provide good solutions to the problem of calculating the SRM in pinhole SPECT reconstruction. The AE-SRM was faster to create and handle the projection noise better than MC-SRM. Nevertheless, the AE-SRM required a tedious experimental characterization of the intrinsic detector response. Creation of the MC-SRM required longer computation time and handled the projection noise worse than the AE-SRM.Nevertheless, the MC-SRM inherently incorporates extensive modeling of the system and therefore experimental characterization was not required.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.11940/4474
url http://hdl.handle.net/20.500.11940/4474
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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