Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes

[EN] Objective: To evaluate the safety and performance of a new multivariable closed-loop (MCL) glucose controller with automatic carbohydrate recommendation during and after unannounced and announced exercise in adults with type 1 diabetes (T1D). Research design and methods: A randomized, 3-arm, cr...

Descripción completa

Detalles Bibliográficos
Autores: Viñals, Clara, Beneyto, Aleix, Hirata-Bertachi, Arthur, Vehí, Josep, Conget, Ignacio, Giménez, Marga, Martín-SanJosé, Juan-Fernando|||0000-0002-3247-6156, Furió-Novejarque, Clara|||0000-0003-2923-6618, Bondía Company, Jorge|||0000-0001-7286-3719
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/196326
Acceso en línea:https://riunet.upv.es/handle/10251/196326
Access Level:acceso abierto
Palabra clave:Artificial pancreas
Type 1 diabetes
Exercise
Closed-loop control
Hypoglycemia prevention and exercise
INGENIERIA DE SISTEMAS Y AUTOMATICA
id ES_8a3e7f80bd9d436fbc34ba2bae86fbaf
oai_identifier_str oai:riunet.upv.es:10251/196326
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
title Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
spellingShingle Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
Viñals, Clara
Artificial pancreas
Type 1 diabetes
Exercise
Closed-loop control
Hypoglycemia prevention and exercise
INGENIERIA DE SISTEMAS Y AUTOMATICA
title_short Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
title_full Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
title_fullStr Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
title_full_unstemmed Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
title_sort Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
dc.creator.none.fl_str_mv Viñals, Clara
Beneyto, Aleix
Hirata-Bertachi, Arthur
Vehí, Josep
Conget, Ignacio
Giménez, Marga
Martín-SanJosé, Juan-Fernando|||0000-0002-3247-6156
Furió-Novejarque, Clara|||0000-0003-2923-6618
Bondía Company, Jorge|||0000-0001-7286-3719
author Viñals, Clara
author_facet Viñals, Clara
Beneyto, Aleix
Hirata-Bertachi, Arthur
Vehí, Josep
Conget, Ignacio
Giménez, Marga
Martín-SanJosé, Juan-Fernando|||0000-0002-3247-6156
Furió-Novejarque, Clara|||0000-0003-2923-6618
Bondía Company, Jorge|||0000-0001-7286-3719
author_role author
author2 Beneyto, Aleix
Hirata-Bertachi, Arthur
Vehí, Josep
Conget, Ignacio
Giménez, Marga
Martín-SanJosé, Juan-Fernando|||0000-0002-3247-6156
Furió-Novejarque, Clara|||0000-0003-2923-6618
Bondía Company, Jorge|||0000-0001-7286-3719
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería de Sistemas y Automática
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Instituto Universitario de Automática e Informática Industrial
Escuela Técnica Superior de Ingeniería Industrial
Generalitat de Catalunya
Hospital Clínic de Barcelona
AGENCIA ESTATAL DE INVESTIGACION
European Regional Development Fund
Ministerio de Educación, Cultura y Deporte
Ministerio de Economía, Industria y Competitividad
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Artificial pancreas
Type 1 diabetes
Exercise
Closed-loop control
Hypoglycemia prevention and exercise
INGENIERIA DE SISTEMAS Y AUTOMATICA
topic Artificial pancreas
Type 1 diabetes
Exercise
Closed-loop control
Hypoglycemia prevention and exercise
INGENIERIA DE SISTEMAS Y AUTOMATICA
description [EN] Objective: To evaluate the safety and performance of a new multivariable closed-loop (MCL) glucose controller with automatic carbohydrate recommendation during and after unannounced and announced exercise in adults with type 1 diabetes (T1D). Research design and methods: A randomized, 3-arm, crossover clinical trial was conducted. Participants completed a heavy aerobic exercise session including three 15-minute sets on a cycle ergometer with 5 minutes rest in between. In a randomly determined order, we compared MCL control with unannounced (CLNA) and announced (CLA) exercise to open-loop therapy (OL). Adults with T1D, insulin pump users, and those with hemoglobin (Hb)A1c between 6.0% and 8.5% were eligible. We investigated glucose control during and 3 hours after exercise. Results: Ten participants (aged 40.8 +/- 7.0 years; HbA1c of 7.3 +/- 0.8%) participated. The use of the MCL in both closed-loop arms decreased the time spent <70 mg/dL of sensor glucose (0.0%, [0.0-16.8] and 0.0%, [0.0-19.2] vs 16.2%, [0.0-26.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.047, P = 0.063) and the number of hypoglycemic events when compared with OL (CLNA 4 and CLA 3 vs OL 8; P = 0.218, P = 0.250). The use of the MCL system increased the proportion of time within 70 to 180 mg/dL (87.8%, [51.1-100] and 91.9%, [58.7-100] vs 81.1%, [65.4-87.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.227, P = 0.039). This was achieved with the administration of similar doses of insulin and a reduced amount of carbohydrates. Conclusions: The MCL with automatic carbohydrate recommendation performed well and was safe during and after both unannounced and announced exercise, maintaining glucose mostly within the target range and reducing the risk of hypoglycemia despite a reduced amount of carbohydrate intake.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/196326
url https://riunet.upv.es/handle/10251/196326
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 DPI2016-78831-C2-1-R SOLUCIONES PARA LA MEJORA DE LA EFICIENCIA Y SEGURIDAD DEL PÁNCREAS ARTIFICIAL MEDIANTE ARQUITECTURAS DE CONTROL MULTIVARIABLE TOLERANTES A FALLOS
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil https://doi.org/10.13039/501100003593 207688%2F2014-1
Generalitat de Catalunya https://doi.org/10.13039/501100002809 2017SGR1551
Ministerio de Educación y Cultura http://dx.doi.org/10.13039/501100003176 FPU15%2F00244 FPU15
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DPI2016-78831-C2-2-R Soluciones para la mejora de la eficiencia y seguridad del pancreas artificial mediante arquitecturas de control multivariable tolerantes a fallos
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Endocrine Society
publisher.none.fl_str_mv The Endocrine Society
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412686577532928
spelling Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 DiabetesViñals, ClaraBeneyto, AleixHirata-Bertachi, ArthurVehí, JosepConget, IgnacioGiménez, MargaMartín-SanJosé, Juan-Fernando|||0000-0002-3247-6156Furió-Novejarque, Clara|||0000-0003-2923-6618Bondía Company, Jorge|||0000-0001-7286-3719Artificial pancreasType 1 diabetesExerciseClosed-loop controlHypoglycemia prevention and exerciseINGENIERIA DE SISTEMAS Y AUTOMATICA[EN] Objective: To evaluate the safety and performance of a new multivariable closed-loop (MCL) glucose controller with automatic carbohydrate recommendation during and after unannounced and announced exercise in adults with type 1 diabetes (T1D). Research design and methods: A randomized, 3-arm, crossover clinical trial was conducted. Participants completed a heavy aerobic exercise session including three 15-minute sets on a cycle ergometer with 5 minutes rest in between. In a randomly determined order, we compared MCL control with unannounced (CLNA) and announced (CLA) exercise to open-loop therapy (OL). Adults with T1D, insulin pump users, and those with hemoglobin (Hb)A1c between 6.0% and 8.5% were eligible. We investigated glucose control during and 3 hours after exercise. Results: Ten participants (aged 40.8 +/- 7.0 years; HbA1c of 7.3 +/- 0.8%) participated. The use of the MCL in both closed-loop arms decreased the time spent <70 mg/dL of sensor glucose (0.0%, [0.0-16.8] and 0.0%, [0.0-19.2] vs 16.2%, [0.0-26.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.047, P = 0.063) and the number of hypoglycemic events when compared with OL (CLNA 4 and CLA 3 vs OL 8; P = 0.218, P = 0.250). The use of the MCL system increased the proportion of time within 70 to 180 mg/dL (87.8%, [51.1-100] and 91.9%, [58.7-100] vs 81.1%, [65.4-87.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.227, P = 0.039). This was achieved with the administration of similar doses of insulin and a reduced amount of carbohydrates. Conclusions: The MCL with automatic carbohydrate recommendation performed well and was safe during and after both unannounced and announced exercise, maintaining glucose mostly within the target range and reducing the risk of hypoglycemia despite a reduced amount of carbohydrate intake.This work has been partially funded by the Spanish Government under grants DPI2016-78831-C2-1-R, DPI2016-78831-C2-2-R, and FPU0244 2015; by the EU through FEDER funds; by the National Counsel of Technological and Scientific Development, CNPq-Brazil 207688/2014-1; and by the Government of Catalonia under 2017SGR1551. C.V. is the recipient of a grant from the Hospital Clinic i Universitari of Barcelona ("Premi Fi de Residencia 2018-2019").The Endocrine SocietyDepartamento de Ingeniería de Sistemas y AutomáticaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialInstituto Universitario de Automática e Informática IndustrialEscuela Técnica Superior de Ingeniería IndustrialGeneralitat de CatalunyaHospital Clínic de BarcelonaAGENCIA ESTATAL DE INVESTIGACIONEuropean Regional Development FundMinisterio de Educación, Cultura y DeporteMinisterio de Economía, Industria y CompetitividadConselho Nacional de Desenvolvimento Científico e Tecnológico, BrasilRepositorio Institucional de la Universitat Politècnica de València Riunet20212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/196326reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 DPI2016-78831-C2-1-R SOLUCIONES PARA LA MEJORA DE LA EFICIENCIA Y SEGURIDAD DEL PÁNCREAS ARTIFICIAL MEDIANTE ARQUITECTURAS DE CONTROL MULTIVARIABLE TOLERANTES A FALLOSConselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil https://doi.org/10.13039/501100003593 207688%2F2014-1Generalitat de Catalunya https://doi.org/10.13039/501100002809 2017SGR1551Ministerio de Educación y Cultura http://dx.doi.org/10.13039/501100003176 FPU15%2F00244 FPU15Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 DPI2016-78831-C2-2-R Soluciones para la mejora de la eficiencia y seguridad del pancreas artificial mediante arquitecturas de control multivariable tolerantes a fallosopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1963262026-06-13T07:49:27Z
score 15,301603

Similares en LA Referencia