Serum albumin is a strong predictor of sepsis outcome in elderly patients

The incidence of sepsis is disproportionately higher in elderly adults, and age is an independent predictor of mortality. Retrospective analysis was conducted among patients admitted to the emergency department in a tertiary teaching hospital from January 2016 to June 2017. To study the prognosis de...

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Autores: Arnau-Barrés, Isabel, Güerri Fernández, Roberto, Luque Pardos, Sònia, Sorli Redó, M. Luisa, Vázquez Ibar, Olga, Miralles Basseda, Ramon
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/37122
Acceso en línea:http://hdl.handle.net/10230/37122
http://dx.doi.org/10.1007/s10096-019-03478-2
Access Level:acceso abierto
Palabra clave:Albúmina
Persones grans -- Malalties
Albumin
Elderly
Mortality
Sepsis
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spelling Serum albumin is a strong predictor of sepsis outcome in elderly patientsArnau-Barrés, IsabelGüerri Fernández, RobertoLuque Pardos, SòniaSorli Redó, M. LuisaVázquez Ibar, OlgaMiralles Basseda, RamonAlbúminaPersones grans -- MalaltiesAlbuminElderlyMortalitySepsisThe incidence of sepsis is disproportionately higher in elderly adults, and age is an independent predictor of mortality. Retrospective analysis was conducted among patients admitted to the emergency department in a tertiary teaching hospital from January 2016 to June 2017. To study the prognosis determinants of sepsis among elderly patients attended in the emergency room of a tertiary care hospital. As secondary objectives, we aimed to describe the causes of sepsis, the general outcome, and the general characteristics of these patients. Two hundred thirty-five episodes data of patients admitted throughout the 15-month study period who were diagnosed with sepsis, severe sepsis or septic shock, were included. Throughout the study cohort, 51 patients (21.7%) fulfilled the criteria of severe sepsis or septic shock. All-cause mortality was 11 patients (4.7%) on day 14 and 27 (11.5%) on day 30. Prognosis factors associated with 30-day mortality were the following: albumin level < 2.6 g/dl (first quartile of the overall population), odds ratio (OR 3.26, 95% CI 12-9.41; p = 0.029), Charlson comorbidity index (OR 1.23, 95% CI 1.04-1.45; p = 0.012), C-reactive protein on admission (OR 1.04, 95% CI 0.99-1.08; p = 0.062), and non-adequacy of the initial antimicrobial therapy (OR 3.3, 95% CI 1.06-10.4; p = 0.039). Among elderly patients with sepsis, strong predictors of mortality such as albumin could be considered as part of prognosis and future potential interventions. Adequacy of antimicrobial therapy at admission must be one of the objectives in the treatment of sepsis, also in the elderly, since it is an independent predictor of mortality.Elsevier20192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/37122http://dx.doi.org/10.1007/s10096-019-03478-2reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEuropean Journal of Clinical Microbiology & Infectious Diseases. 2019 Apr;38(4):743-6© Elsevier http://dx.doi.org/10.1007/s10096-019-03478-2info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/371222026-06-12T07:21:37Z
dc.title.none.fl_str_mv Serum albumin is a strong predictor of sepsis outcome in elderly patients
title Serum albumin is a strong predictor of sepsis outcome in elderly patients
spellingShingle Serum albumin is a strong predictor of sepsis outcome in elderly patients
Arnau-Barrés, Isabel
Albúmina
Persones grans -- Malalties
Albumin
Elderly
Mortality
Sepsis
title_short Serum albumin is a strong predictor of sepsis outcome in elderly patients
title_full Serum albumin is a strong predictor of sepsis outcome in elderly patients
title_fullStr Serum albumin is a strong predictor of sepsis outcome in elderly patients
title_full_unstemmed Serum albumin is a strong predictor of sepsis outcome in elderly patients
title_sort Serum albumin is a strong predictor of sepsis outcome in elderly patients
dc.creator.none.fl_str_mv Arnau-Barrés, Isabel
Güerri Fernández, Roberto
Luque Pardos, Sònia
Sorli Redó, M. Luisa
Vázquez Ibar, Olga
Miralles Basseda, Ramon
author Arnau-Barrés, Isabel
author_facet Arnau-Barrés, Isabel
Güerri Fernández, Roberto
Luque Pardos, Sònia
Sorli Redó, M. Luisa
Vázquez Ibar, Olga
Miralles Basseda, Ramon
author_role author
author2 Güerri Fernández, Roberto
Luque Pardos, Sònia
Sorli Redó, M. Luisa
Vázquez Ibar, Olga
Miralles Basseda, Ramon
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Albúmina
Persones grans -- Malalties
Albumin
Elderly
Mortality
Sepsis
topic Albúmina
Persones grans -- Malalties
Albumin
Elderly
Mortality
Sepsis
description The incidence of sepsis is disproportionately higher in elderly adults, and age is an independent predictor of mortality. Retrospective analysis was conducted among patients admitted to the emergency department in a tertiary teaching hospital from January 2016 to June 2017. To study the prognosis determinants of sepsis among elderly patients attended in the emergency room of a tertiary care hospital. As secondary objectives, we aimed to describe the causes of sepsis, the general outcome, and the general characteristics of these patients. Two hundred thirty-five episodes data of patients admitted throughout the 15-month study period who were diagnosed with sepsis, severe sepsis or septic shock, were included. Throughout the study cohort, 51 patients (21.7%) fulfilled the criteria of severe sepsis or septic shock. All-cause mortality was 11 patients (4.7%) on day 14 and 27 (11.5%) on day 30. Prognosis factors associated with 30-day mortality were the following: albumin level < 2.6 g/dl (first quartile of the overall population), odds ratio (OR 3.26, 95% CI 12-9.41; p = 0.029), Charlson comorbidity index (OR 1.23, 95% CI 1.04-1.45; p = 0.012), C-reactive protein on admission (OR 1.04, 95% CI 0.99-1.08; p = 0.062), and non-adequacy of the initial antimicrobial therapy (OR 3.3, 95% CI 1.06-10.4; p = 0.039). Among elderly patients with sepsis, strong predictors of mortality such as albumin could be considered as part of prognosis and future potential interventions. Adequacy of antimicrobial therapy at admission must be one of the objectives in the treatment of sepsis, also in the elderly, since it is an independent predictor of mortality.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/37122
http://dx.doi.org/10.1007/s10096-019-03478-2
url http://hdl.handle.net/10230/37122
http://dx.doi.org/10.1007/s10096-019-03478-2
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Journal of Clinical Microbiology & Infectious Diseases. 2019 Apr;38(4):743-6
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1007/s10096-019-03478-2
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1007/s10096-019-03478-2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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